CARDIOVASCULAR JOURNAL OF AFRICA: VOLUME 14, ISSUE 3, MAY 2003
  1. Title: Ambulatory blood pressure measurement is now indispensable to the good clinical management of hypertension : editorial
    Authors: O'Brien, Eoin
    From: Cardiovascular Journal of South Africa, Vol 14, Issue 3, May / Jun
    Published: 2003
    Pages: p.113-119
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  2. Title: The effect of different apo(a) isoforms on plasminogen activation in black South African subjects : cardiovascular topics
    Authors: Choma, S.R.; Alberts, M.; Potgieter, H.C.; Ojwang, P.J.
    From: Cardiovascular Journal of South Africa, Vol 14, Issue 3, May / Jun
    Published: 2003
    Pages: p.120-124
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    Abstract: Objective : The present study evaluates the effect of different apolipoprotein(a) [apo(a)] isoforms on plasminogen activation.
    Design : A cross-sectional study.
    Setting : A rural village (Dikgale district ) in the Northern Province of South Africa.
    Subjects : A total of 90 apparently healthy subjects (64 females and 36 males) aged 43 to 67 years participated in the study.
    Results : The mean lipoprotein(a) [Lp(a)] level in the subjects was 38.14 ± 22.34 mg / dl. No association was found between Lp(a) levels and apo(a) isoforms. When the ratio of Lp(a) : plasminogen was less than 1.3, a competitive inhibition was observed, but when the ratio exceeded 1.3, an uncompetitive inhibition was observed with all isoforms.
    Conclusion : The results of the present study suggest that the inhibition of plasminogen activation by Lp(a) is not dependent on apo(a) size.
     
  3. Title: Risk factors and methylenetetrahydrofolate reductase gene polymorphisms in a young South African Indian-based population with acute myocardial infarction : cardiovascular topics
    Authors: Ranjith, N.; Pegoraro, R.J.; Rom, L.
    From: Cardiovascular Journal of South Africa, Vol 14, Issue 3, May / Jun
    Published: 2003
    Pages: p.127-132
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    Abstract: Although coronary heart disease (CHD) is extremely common in South African Indians, there is little published data on the possible causes leading to myocardial infarction (MI) in young Indians. The aim of this study was to identify common environmental risk factors and to examine the relationship between two polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, the 677 C→T and 1298 A→C in young South African Indians with MI.
    Demographic and risk factor data were obtained from 245 patients ≤ 45 years with MI who were admitted to the RK Khan Hospital, Durban. Venous blood from 195 of the 245 patients with MI, as well as from the siblings of the MI patients (n = 107), and 300 healthy agematched Indian control subjects, were collected for genetic analysis.
    Cigarette smoking was the most important risk factor, occurring in three-quarters of patients, followed by dyslipidaemia in half of the subjects. Diabetes (19%) and hypertension (22%) were found not to be major risk factors for MI. A strong familial link was observed not only for a history of CHD (54%), but also for diabetes (42%) and hypertension (41%).
    No difference was found in the thermolabile variant of the MTFHR gene (677 C→T) or the second variant 1298 A→C between healthy controls and patients with MI or their siblings. The two polymorphisms did not appear to work in synergy, neither was there any relationship to common risk factors for CHD.
    In conclusion, smoking, dyslipidaemia and obesity were the most common phenotypic risk factors for MI. Neither the 677 C→T nor the 1298 A→C MTFHR variants appeared to be risk factors for premature CHD in this group.
     
  4. Title: Evaluation of left ventricular enlargement in the lateral position of the chest using the Hoffman and Rigler sign : cardiovascular topics
    Authors: Freeman, V.; Mutatiri, C.; Pretorius, M.; Doubell, A.
    From: Cardiovascular Journal of South Africa, Vol 14, Issue 3, May / Jun
    Published: 2003
    Pages: p.134-137
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    Abstract: Objective : To evaluate left ventricular enlargement in the lateral projection of the chest using the Hoffman and Rigler sign.
    Background : The Hoffman and Rigler sign for determining left ventricular enlargement was suggested as early as 1965 before the routine use of echocardiography.
    Methods : We studied 136 patients who had had cardiac ultrasound and chest X-rays with lateral projections. We assessed left ventricular size on the lateral projection using the Hoffman and Rigler method (measurement A) and compared this measurement to the value obtained by cardiac ultrasound. The effect of right ventricular size on this measurement was also evaluated.
    Results : The average value of measurement A in all patients with echocardiographic evidence of left ventricular enlargement (LVED above 59 mm) was 19 mm (SD ± 4.03) (95% CI 17.96 to 20.04). Of the 48 patients with a normal size left ventricle on echocardiography, 25.58% had measurement A 18 mm and above, and 13.95% had a value 19 mm and above. Of the 19 patients with right ventricular enlargement (normal left ventricle) on echocardiography, 36.84% had measurement A 18 mm and above, whereas 21.05% had this value 19 mm and above. Measurement A in patients with left ventricular enlargement compared with those with right ventricular enlargement showed a significant difference (p < 0.05).
    Conclusions : When the crossing of the inferior vena cava and the left ventricle can be adequately visualised, the Hoffman and Rigler sign of evaluating left ventricular enlargement in the lateral projection of the chest is a valuable alternative where cardiac ultrasound is not readily available.
     
  5. Title: Multiple cardiac abnormalities in a case of non-mosaic trisomy 8 : case report
    Authors: Hendson, W.; Levin, S.E.; Govendrageloo, K.; Hunter, V.
    From: Cardiovascular Journal of South Africa, Vol 14, Issue 3, May / Jun
    Published: 2003
    Pages: p.138-140
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    Abstract: We present a case of complete trisomy 8 in a 40-day-old male infant, who had a number of congenital heart abnormalities.
     
  6. Title: Enhanced myocardial contractility associated with hypercalcaemia of hyperparathyroidism - a case study in six patients : case report
    Authors: Otto, Anton C.; Nel, Maria G.; Van Staden, Johan A.; Dunn, Marianna; Van Aswegen, Andries; Nel, Riette
    From: Cardiovascular Journal of South Africa, Vol 14, Issue 3, May / Jun
    Published: 2003
    Pages: p.141-143
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    Abstract: The possible association of increased left ventricular ejection fraction (LVEF) in patients with increased serum Ca2+ was observed in our clinic. Six patients with confirmed primary hyperparathyroidism and hypercalcaemia were studied prospectively. Tc-99m sestamibi gated SPECT was done pre- and postoperatively. The LVEF was abnormally high in all the patients preoperatively, i.e. above the normal reference range (47-61%) as used in our clinic. It decreased in all of them postoperatively, yet in only three patients to values within the normal range. This was associated with normalisation of the serum Ca2+ values. The median of the pre-operative LVEF was 74% and postoperative it was 61.5%. The median difference was 9% with a 95% CI for the median difference for paired data (6; 26). This was statistically significant. Increased LVEF was not previously described as part of the clinical picture of primary hyperparathyroidism. The in vivo effect of chronic hypercalcaemia on LV pump function may need to be revisited.
     
  7. Title: Molecular genetics of cardiomyopathy : changing times, shifting paradigms : review article
    Authors: Moolman-Smook, Johanna C.; Mayosi, Bongani M.; Brink, Paul A.; Corfield, Valerie A.
    From: Cardiovascular Journal of South Africa, Vol 14, Issue 3, May / Jun
    Published: 2003
    Pages: p.145-155
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    Abstract: Congestive heart failure is a major problem in developed and developing countries alike. Primary dysfunction of the heart muscle accounts for a significant proportion of patients with a non-ischaemic cause of heart failure. Application of genetic techniques has facilitated identification of some molecular causes of the inherited form of these diseases, dramatically increasing our understanding of the pathogenesis of these primary, previously termed 'idiopathic', cardiomyopathies over the last few decades. Knowledge of the different causes is beginning to coalesce into aetiological principles underlying the clinically distinguished cardiomyopathies. Hypertrophic cardiomyopathy (HCM) now appears to be a disease caused by a dysfunctional sarcomere, dilated cardiomyopathy (DCM), a disease of myocytic structural instability, and arrhythmogenic right ventricular cardiomyopathy, a disease of accelerated myocyte death. The aetiology of both HCM and DCM probably also involves cardiac energy imbalances, while additional factors modify the clinical expression in all cardiomyopathies. Even though our knowledge of the genetic aetiology of the cardiomyopathies is still incomplete, it already has relevant clinical significance. Elucidation of the full genetic contribution to the development and progression of the cardiomyopathies represents a new challenge in the study of these diseases, and will undoubtedly lead to new therapeutic approaches in the not-too-distant future.
     
  8. Title: Do ACE inhibitors have a real role in coronary artery disease? : drug trends in cardiology
    From: Cardiovascular Journal of South Africa, Vol 14, Issue 3, May / Jun
    Published: 2003
    Pages: p.156
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  9. Title: Dramatic new trial results settle controversy in chronic heart failure : drug trends in cardiology
    From: Cardiovascular Journal of South Africa, Vol 14, Issue 3, May / Jun
    Published: 2003
    Pages: p.157
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  10. Title: Rosuvastatin achieves new standards in lipid management : drug trends in cardiology
    From: Cardiovascular Journal of South Africa, Vol 14, Issue 3, May / Jun
    Published: 2003
    Pages: p.157-158
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  11. Title: Clopidogrel reduces death, stroke, heart attack now and later : drug trends in cardiology
    From: Cardiovascular Journal of South Africa, Vol 14, Issue 3, May / Jun
    Published: 2003
    Pages: p.158-159
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  12. Title: Cholesterol-lowering action of policosanol compares well to that of pravastatin and lovastatin : drug trends in cardiology
    From: Cardiovascular Journal of South Africa, Vol 14, Issue 3, May / Jun
    Published: 2003
    Pages: p.161
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  13. Title: Recent review highlights implications for prevention of cardiovascular disease : drug trends in cardiology
    From: Cardiovascular Journal of South Africa, Vol 14, Issue 3, May / Jun
    Published: 2003
    Pages: p.161-162
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  14. Title: Outcomes data for Atacand(R) : results of the SCOPE study : drug trends in cardiology
    From: Cardiovascular Journal of South Africa, Vol 14, Issue 3, May / Jun
    Published: 2003
    Pages: p.162
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  15. Title: The William Nelson ECG quiz
    From: Cardiovascular Journal of South Africa, Vol 14, Issue 3, May / Jun
    Published: 2003
    Pages: p.164, 168
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  16. Title: Cardio news
    From: Cardiovascular Journal of South Africa, Vol 14, Issue 3, May / Jun
    Published: 2003
    Pages: p.165-166
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A preliminary review of warfarin toxicity in a tertiary hospital in Cape Town, South Africa

Published: 21 June 2017
 
Perceptions of radiation safety training among interventionalists in South Africa

Published: 24 May 2017
 
Effects of age on systemic inflamatory response syndrome and results of coronary bypass surgery

Published: 23 May 2017
 
Pilot study of risk factors associated with cardiovascular disease in northern and southern Cameroonians

Published: 17 May 2017
 
Clinical profile, management and outcomes of patients with pulmonary embolism: a retrospective tertiary centre study in Angola

Published: 17 May 2017
 
Role of melatonin in glucose uptake by cardiomyocytes from insulin-resistant Wistar rats

Published: 17 May 2017
 
Atorvastatin inhibits cholesterol-induced caspase-3 cleavage through down-regulation of p38 and up-regulation of Bcl-2 in the rat carotid artery

Published: 10 May 2017
 
Relationship between coronary tortuosity and plateletcrit coronary tortuosity and plateletcrit

Published: 26 April 2017
 
Clinical presentation and outcomes of patients with acute rheumatic fever and rheumatic heart disease seen at a tertiary hospital setting in Port Elizabeth, South Africa

Published: 20 April 2017
 
 
Electrocardiographic abnormalities in treatment-naïve HIV subjects in south-east Nigeria

Published: 24 March 2017
 
 
Medication adherence among cardiac patients in Khartoum State, Sudan: a cross-sectional study

Published: 24 March 2017
 
 
An unusual case of aorta–right atrial tunnel with windsock aneurysm: imaging, diagnosis and treatment

Published: 15 March 2017
 
 
Prevalence of rheumatic valvular heart disease in Rwandan school children: echocardiographic evaluation using the World Heart Federation criteria

Published: 1 March 2017
 
 
Factors affecting interest in cardiothoracic surgery among junior surgical residents in Nigeria

Published: 1 March 2017
 
 
New World’s old disease: cardiac hydatid disease and surgical principles

Published: 20 February 2017
 
 
The prevalence and radiological findings of pulmonary embolism in HIV-positive patients referred for computed tomography pulmonary angiography in the Western Cape of South Africa

Published: 15 February 2017
 
 
Right ventricular strain as predictor of pulmonary complications in patients with femur fracture

Published: 01 February 2017
 
 
Atrial myxoma: a rare cause of hemiplegia in children

Published: 09 December 2016
 
 
Telmisartan decreases microalbuminuria in patients with type 2 diabetes mellitus following coronary artery bypass grafting

Published: 10 November 2016
 
 
Left ventricular haematoma mimicking lateral wall myocardial infarction secondary to percutaneous coronary intervention

Published: 10 November 2016
 
 
Symptom-to-balloon time and myocardial blush grade are predictors of left ventricular remodelling after successful primary percutaneous coronary intervention

Published: 27 October 2016
 
 
Effects of Ramadan intermittent fasting on North African children’s heart rate and oxy-haemoglobin saturation at rest and during sub-maximal exercise

Published: 21 October 2016
 
 
Xanthine oxidase inhibitors in ischaemic heart disease

Published: 09 September 2016
 
 
Prevalence of selected cardiometabolic risk factors among adults in urban and semi-urban hospitals in four sub-Saharan African countries

Published: 22 August 2016
 
 
Assessment of indirect inflammatory markers in patients with myocardial bridging

Published: 19 August 2016
 
 
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