CARDIOVASCULAR JOURNAL OF AFRICA: VOLUME 18, ISSUE 2, MARCH 2007
  1. Title: From the editor's desk
    Authors: Brink, Andries
    From: Cardiovascular Journal of South Africa, Vol 18, Issue 2, Mar / Apr
    Published: 2007
    Pages: 68
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  2. Title: Cardiovascular effects of Persea americana Mill (Lauraceae) (avocado) aqueous leaf extract in experimental animals : cardiovascular topic
    Authors: Musabayane, C.T.; Moodley, K.; Gondwe, M.M.; Kamadyaapa, D.R.; Ojewole, J.A.O.
    From: Cardiovascular Journal of South Africa, Vol 18, Issue 2, Mar / Apr
    Published: 2007
    Pages: 69-76
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    Abstract: The cardiovascular effects of Persea Americana Mill (Lauraceae) aqueous leaf extract (PAE) have been investigated in some experimental animal paradigms. The effects of PAE on myocardial contractile performance was evaluated on guinea pig isolated atrial muscle strips, while the vasodilatory effects of the plant extract were examined on isolated portal veins and thoracic aortic rings of healthy normal Wistar rats in vitro. The hypotensive (antihypertensive) effect of the plant extract was examined in healthy normotensive and hypertensive Dahl salt-sensitive rats in vivo.
    P americana aqueous leaf extract (25-800 mg/ml) produced concentration-dependent, significant (p < 0.05-0.001), negative inotropic and negative chronotropic effects on guinea pig isolated electrically driven left and spontaneously beating right atrial muscle preparations, respectively. Moreover, PAE reduced or abolished, in a concentration-dependent manner, the positive inotropic and chronotropic responses of guinea pig isolated atrial muscle strips induced by noradrenaline (NA, 10-10-10-5 M), and calcium (Ca2+, 5-40 mM). PAE (50-800 mg/ml) also significantly reduced (p < 0.05-0.001) or abolished, in a concentration-dependent manner, the rhythmic, spontaneous, myogenic contractions of portal veins isolated from healthy normal Wistar rats. Like acetylcholine (ACh, 10-8-10-5 M), the plant extract (25- 800 mg/ml) produced concentration-related relaxations of isolated endothelium-containing thoracic aortic rings pre-contracted with noradrenaline. The vasorelaxant effects of PAE in the isolated, endothelium-intact aortic rings were markedly inhibited or annulled by NG-nitro- L-arginine methyl ester (L-NAME, 10-5 M), a nitric oxide synthase inhibitor. Furthermore, PAE (25-400 mg/kg iv) caused dose-related, transient but significant reductions (p < 0.05-0.001) in the systemic arterial blood pressure and heart rates of the anaesthetised normotensive and hypertensive rats used.
    The results of this laboratory animal study indicate that PAE caused bradycardia, vasorelaxation and hypotension in the mammalian experimental models used. The vasorelaxant action of PAE was endothelium dependent, and was, therefore, possibly dependent on the synthesis and release of nitric oxide (NO). The vasorelaxant effects of PAE appeared to contribute significantly to the hypotensive (antihypertensive) effects of the plant extract. However, the findings of this study tend to suggest that P Americana leaf could be used as a natural supplementary remedy in essential hypertension and certain cases of cardiac dysfunctions in some rural Africa communities.
     
  3. Title: Unexpectedly high prevalence of target-organ damage in newly diagnosed Nigerians with hypertension : cardiovascular topic
    Authors: Okpechi, Ikechi; Oluleye, T.S.; Bekibele, C.O.; Adedapo, K.S.; Adebiyi, A.A.; Ogah, O.S.; Salako, B.L.
    From: Cardiovascular Journal of South Africa, Vol 18, Issue 2, Mar / Apr
    Published: 2007
    Pages: 77-83
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    Abstract: Introduction: Hypertension remains a formidable cardiovascular problem in the entire world. Untreated or poorly controlled hypertension predisposes to target-organ damage and is often followed by serious cardiovascular events. Knowledge of the type and distribution of endorgan damage in newly diagnosed hypertensive patients would help to determine the interventions or preventative measures needed in such patients.
    Objective: To assess target-organ involvement in newly diagnosed, untreated hypertensive patients presenting at the University College Hospital, ibadan, Nigeria.
    Methods: Newly diagnosed hypertensive men and women were recruited consecutively into the study. Target-organ damage was assessed using electroctrocardiography, echocardiography, renal function assessment (including tests for albuminuria) and fundoscopy.
    Results: A total of 68 subjects were recruited, but only 54 (79.4%), with a mean age of 59.1 (+ 12.4) years, completed the study. There were 29 (+ 53.7%) men, mean age 63.5 (+ 12.6) years, and 25 (46.3%) women, mean age 54.1 (+ 10.4) years. Fifty per cent of the subjects had no symptoms. Some form of albuminuria was found in about 40.7%. Seventy-one per cent (71%) had between grade 1 and 2 hypertensive retinopathy. Only six (11.1%) had glomerular filtration rate greater than 90 ml/min. Systolic function was impaired in three (5.6%) of the subjects. Diastolic dysfunction was present in 36 (66.7%) subjects.
    Conclusion: Target-organ damage already exists in newly diagnosed hypertensive subjects before presentation. We suggest early screening for cardiovascular risk factors and possibly a reduction in the criteria for the definition of hypertension in black Africans.
     
  4. Title: Pulmonary arterial hypertension after splenectomy for hereditary spherocytosis : case report
    Authors: Louw, V.J.; Smedema, J.P.
    From: Cardiovascular Journal of South Africa, Vol 18, Issue 2, Mar / Apr
    Published: 2007
    Pages: 84-89
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    Abstract: Hereditary spherocytosis consists of a group of haemolytic anaemias caused by defects in the proteins involved in the vertical interactions between the membrane skeleton and the lipid bilayer of the red blood cell. inheritance is most commonly autosomal dominant with variable expression. Splenectomy may be indicated because of anaemia or for the prevention of gall-stones. We describe a patient who presented with symptoms of pulmonary hypertension 32 years after splenectomy. idiopathic pulmonary arterial hypertension (iPAH) and chronic thromboembolic pulmonary hypertension (CTEPH) have been associated with splenectomy, while chronic haemolysis may result in haemolysis-associated pulmonary hypertension. We briefly discuss the current views on the pathophysiology, diagnosis and management of this rare condition.
     
  5. Title: Beta-blockers in 2007? : the cardiovascular prescriber
    Authors: Straughan, John L.
    From: Cardiovascular Journal of South Africa, Vol 18, Issue 2, Mar / Apr
    Published: 2007
    Pages: 90-92
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  6. Title: Eprosartan in secondary prevention of stroke : the economic evidence : short communication
    Authors: Wessels, Francois
    From: Cardiovascular Journal of South Africa, Vol 18, Issue 2, Mar / Apr
    Published: 2007
    Pages: 95-96
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  7. Title: Pan-African Society of Cardiology, Nairobi, Kenya, 13-16 May 2007 : congress abstracts
    From: Cardiovascular Journal of South Africa, Vol 18, Issue 2, Mar / Apr
    Published: 2007
    Pages: 98-125
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  8. Title: Clinical results of GENRES should provide a platform to guide the choice of antihypertensive drug treatment : the AB/CD scheme : drug trends in cardiology
    From: Cardiovascular Journal of South Africa, Vol 18, Issue 2, Mar / Apr
    Published: 2007
    Pages: 126
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  9. Title: Atorvastatin cuts risk of coronary events by half in recurrent stroke patients : drug trends in cardiology
    From: Cardiovascular Journal of South Africa, Vol 18, Issue 2, Mar / Apr
    Published: 2007
    Pages: 128
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  10. Title: Cardiologists applaud drug duet : drug trends in cardiology
    From: Cardiovascular Journal of South Africa, Vol 18, Issue 2, Mar / Apr
    Published: 2007
    Pages: 128, 130
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  11. Title: Targeting the reduction of atherosclerosis in low-risk individuals. METEOR trial provides support for rosuvastatin (Crestor) atherosclerosis regulatory submission : drug trends in cardiology
    From: Cardiovascular Journal of South Africa, Vol 18, Issue 2, Mar / Apr
    Published: 2007
    Pages: 130
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  12. Title: Cardio news
    From: Cardiovascular Journal of South Africa, Vol 18, Issue 2, Mar / Apr
    Published: 2007
    Pages: 132
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Efficacy of cardiac magnetic resonance imaging in a sub-aortic aneurysm case

Published: 29 June 2017
 
 
A preliminary review of warfarin toxicity in a tertiary hospital in Cape Town, South Africa

Published: 21 June 2017
 
 
Effects of age on systemic inflamatory response syndrome and results of coronary bypass surgery

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Pilot study of risk factors associated with cardiovascular disease in northern and southern Cameroonians

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Clinical profile, management and outcomes of patients with pulmonary embolism: a retrospective tertiary centre study in Angola

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Role of melatonin in glucose uptake by cardiomyocytes from insulin-resistant Wistar rats

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Atorvastatin inhibits cholesterol-induced caspase-3 cleavage through down-regulation of p38 and up-regulation of Bcl-2 in the rat carotid artery

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Relationship between coronary tortuosity and plateletcrit coronary tortuosity and plateletcrit

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Clinical presentation and outcomes of patients with acute rheumatic fever and rheumatic heart disease seen at a tertiary hospital setting in Port Elizabeth, South Africa

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Electrocardiographic abnormalities in treatment-naïve HIV subjects in south-east Nigeria

Published: 24 March 2017
 
 
Medication adherence among cardiac patients in Khartoum State, Sudan: a cross-sectional study

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An unusual case of aorta–right atrial tunnel with windsock aneurysm: imaging, diagnosis and treatment

Published: 15 March 2017
 
 
Prevalence of rheumatic valvular heart disease in Rwandan school children: echocardiographic evaluation using the World Heart Federation criteria

Published: 1 March 2017
 
 
Factors affecting interest in cardiothoracic surgery among junior surgical residents in Nigeria

Published: 1 March 2017
 
 
New World’s old disease: cardiac hydatid disease and surgical principles

Published: 20 February 2017
 
 
The prevalence and radiological findings of pulmonary embolism in HIV-positive patients referred for computed tomography pulmonary angiography in the Western Cape of South Africa

Published: 15 February 2017
 
 
Right ventricular strain as predictor of pulmonary complications in patients with femur fracture

Published: 01 February 2017
 
 
Atrial myxoma: a rare cause of hemiplegia in children

Published: 09 December 2016
 
 
Left ventricular haematoma mimicking lateral wall myocardial infarction secondary to percutaneous coronary intervention

Published: 10 November 2016
 
 
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