CARDIOVASCULAR JOURNAL OF AFRICA • Vol 23, No 7, August 2012
388
AFRICA
on a consecutive sample of patients (40) who presented in our
department with DCM in NYHA stage III to IV during a seven-
month period. A larger study population would bring more
significance to the present data. We were not able to determine
the aetiology of the DCM in some patients.
Conclusion
The assessment of cardiac dyssynchrony is possible in
our country but it remains largely untapped due to the low
availability of the techniques and the inaccessibility of
CRT. Intra-ventricular mechanical dyssynchrony has a high
prevalence in patients with DCM, irrespective of the QRS
width. A substantial proportion of patients with DCM and
narrow QRS exhibiting intra-LVD may benefit from CRT.
These data emphasise the value of echocardiography in the
screening of patients.
References
1.
Gorcsan III J, Abraham T, Agler AD, Bax JJ, Derumeaux G, Richard A.
et al
. ASE Expert Consensus Statement. Echocardiography for Cardiac
Resynchronization Therapy: Recommendations for Performance and
Reporting – A report from the American Society of Echocardiography
Dyssynchrony Writing Group Endorsed by the Heart Rhythm Society.
J Am Soc Echocardiogr
2008;
21
: 191–213.
2.
Grines CL,
Bashore TM, Boudoulas H,
Olson S, Shafer P, Wooley
CF. Functional abnormalities in isolated left bundle branch block. The
effect of interventricular asynchrony.
Circulation
1989;
79
: 845–853.
3.
Iuliano S, Fisher SG, Karasik PE, Fletcher RD, Singh SN. Department of
veterans Affairs Survival Trial of Antiarrhytmic Therapy in Congestive
Heart Failure. QRS duration and mortality in patients.
Am Heart J
2002;
143
: 1085–1091.
4.
Bristow MR, Saxon LA, Boehmer J, Krueger S, Kass DA, de Marco T,
Carson P,
et al
. Cardiac-resynchronization therapy with or without an
implantable defibrillator in advanced chronic heart failure.
N Engl J
Med
2004;
350
: 2140–2150.
5.
Focused Update of ESC Guidelines on device therapy in heart failure
2010. An update of the 2008 ESC guidelines for the diagnosis and
treatment of acute and chronic heart failure and the 2007 ESC guide-
lines for cardiac and resynchronization therapy.
Eur Heart J
2010;
31
:
2677–2687.
6.
Jurcut R, Pop I, Calin C, Coman IM, Ciudin R, Ginghina C. Utility of
QRS width and echocardiography parameters in an integrative algo-
rithm for selecting heart failure patients with cardiac dyssynchrony.
Eur
J Intern Med
2009;
20
: 213–220.
7.
Kass DA. Ventricular dyssynchrony and mechanisms of resynchroniza-
tion therapy.
Eur Heart J
2002;
4
(Suppl D): 23–30.
8.
Cleland JG, Daubert JC, Erdmann E, Freemantle N, Gras D,
Kappenberger L,
et al
. Longer-term effects of cardiac resynchronization
therapy on mortality in heart failure [the Cardiac REsynchronization-
Heart Failure (CARE-HF) trial extension phase].
Eur Heart J
2006;
27
: 1928–1932.
9.
Schuster I, Habib G, Jego C, Thuny F, Avierinos JF, Derumeaux G,
et
al
. Diastolic asynchrony is more frequent than systolic asynchrony in
dilated cardiomyopathy and is less improved by cardiac resynchroniza-
tion therapy.
J Am Coll Cardiol
2005;
46
: 2250–2257.
10. Bader H, Garrigue S, Lafitte S, Reuter S, Jaïs P, Haïssaguerre M,
et al
.
Intra-left ventricular electromechanical asynchrony. A new independent
predictor of severe cardiac events in heart failure patients.
J Am Coll
Cardiol
2004;
43
: 248–256
11. Ghio S, Freemantle N, Serio A, Magrini G, Scelsi L, Pasotti M,
et al
. Baseline echocardiographic characteristics of heart failure
patients enrolled in a large European multicentre trial (CArdiac
REsynchronisation Heart Failure study).
Eur J Echocardiogr
2006;
7
:
373–378.
12. Ghio S, Constantin C, Klersy C, Serio A, Fontana A, Campana C,
et
al
. Interventricular and intraventricular dyssynchrony are common in
heart failure patients, regardless of QRS duration.
Eur Heart J
2004;
25
: 571–578.
13. The Task Force for Cardiac Pacing and Cardiac Resynchronization
Therapy of the European Society of Cardiology. Developed in
Collaboration with the European Heart RhythmAssociation Guidelines
for cardiac pacing and cardiac resynchronization therapy
Europace
2007;
10
: 959–998.
14. Perez de Isla L, Florit J, Garcia-Fernandez MA, Evangelista A,
Zamorano J. Prevalence of echocardiographically detected ventricular
asynchrony in patients with left ventricular systolic dysfunction.
J Am
Soc Echocardiogr
2005;
18
: 850–859.
15. Penicka M, Bartunek J, De Bruyne B, Vanderheyden M, Goethals
M, De Zutter M,
et al
. Improvement of left ventricular function after
cardiac resynchronization therapy is predicted by tissue Doppler imag-
ing echocardiography.
Circulation
2004;
109
: 978–983.