CARDIOVASCULAR JOURNAL OF AFRICA:
VOLUME 15, ISSUE 5, SEP 2004
- Title: Cellular injury in ischaemia
: editorial comment
Authors: Lochner, A.; Koeslag, J.H.; Du Toit, E.F.; Huisamen, B.; Moolman, J.A.; Van Rooyen, J.
From: Cardiovascular Journal of South Africa, Vol 15, Issue 5, Sep / Oct
Published: 2004
Pages: p.205-206
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- Title: Hyperhomocyst(e)inemia is an
important risk factor for vascular disease in
subjects with high-molecular weight apo(a)
isoforms : cardiovascular topics
Authors: Delport, Rhena; Lingenhel, Arnulf W.; Ubbink, Johan B.; Kraft, Hans G.
From: Cardiovascular Journal of South Africa, Vol 15, Issue 5, Sep / Oct
Published: 2004
Pages: p.207-213
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Abstract: Background: Homocyst(e)ine is reported to increase the binding of lipoprotein(a) [Lp(a)] to fibrin, which may increase the thrombogenic effects of Lp(a) in vivo. The aim of this study was to investigate whether there is a relationship between homocyst(e)ine and Lp(a) levels and vascular disease risk, and if the relationship depends on the apo(a) isoforms.
Methods: A case-control study was performed in 91 Caucasian male subjects with vascular disease due to athersclerosis, and in 100 healthy age- and sex-matched control subjects.
Results: Both hyperhomocyst(e)inemia and elevated Lp(a) were significantly more prevalent in patients. Concordant elevated Lp(a) and hyperhomocyst(e)inemia were not associated with increased vascular disease risk (relative odds 2.96; 95% CI: 0.90-9.80), while hyperhomocyst(e)inemia in the absence of elevated Lp(a) was associated with increased vascular disease risk (relative odds 7.20; 95% CI: 2.37-21.91). Hyperhomocyst(e)inemia in individuals with high-molecular weight apo(a) isoforms [smaller apo(a) isoform > S3] was observed to be associated with increased vascular disease risk (relative odds 11.02; 95% CI: 3.54-34.30), while vascular disease risk in subjects with low-molecular weight apo(a) isoforms [smaller apo(a) isoform < S3] was not significantly increased, the relative odds being 1.92; 95% CI: 0.51-7.24.
Conclusions: We conclude that hyperhomocyst(e)inemia is an important risk factor in individuals with highmolecular weight apo(a) isoforms.
- Title: Risk factors and
complications of hypertension in Yaounde,
Cameroon : cardiovascular topics
Authors: Shey Wiysonge, C.U.; Ngu Blackett, K.; Mbuagbaw, J.N.
From: Cardiovascular Journal of South Africa, Vol 15, Issue 5, Sep / Oct
Published: 2004
Pages: p.215-219
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Abstract: Aim: To determine the risk factors and complications of hypertension, isolated systolic hypertension (ISH) and isolated diastolic hypertension (IDH) in Yaounde.
Methods and Results: Between January and September 1998 we examined 813 consecutive adult patients (46.5% men) in the Yaounde University Teaching Hospital, with special focus on risk factors of hypertension and clinical findings in the cardiovascular system. We measured systolic blood pressure, diastolic blood pressure, body mass index and plasma glucose, and recorded chest X-ray, electrocardiogram and echocardiogram. Hypertension, ISH and IDH were defined using the WHO-ISH 1999 criteria. After controlling for the confounding effects of age and sex, hypertension was significantly associated with obesity, family history of hypertension, alcohol intake, heart failure, stroke and left ventricular hypertrophy (p < 0.01); smoking was significantly associated with ISH (p = 0.04), and no factor was independently associated with IDH.
Conclusions: A prevention strategy for hypertension and its resultant complications in Cameroon should include measures aimed at obesity and alcohol consumption, as well as early diagnosis with the institution of effective and affordable therapy.
- Title: Metabolic Cardiomyopathy, H.
Böhles, A.C. Sewell : book review
Authors: Brink, P.A.
From: Cardiovascular Journal of South Africa, Vol 15, Issue 5, Sep / Oct
Published: 2004
Pages: p.220
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- Title: SA Heart Association National
Congress, 6-8 October 2004, ICC, Durban :
abstracts
From: Cardiovascular Journal of South Africa, Vol 15, Issue 5, Sep / Oct
Published: 2004
Pages: p.221-246
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- Title: New pathophysiological
insights explain life-saving benefits of
perindopril in coronary artery disease patients
: drug trends in cardiology
From: Cardiovascular Journal of South Africa, Vol 15, Issue 5, Sep / Oct
Published: 2004
Pages: p.248-249
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- Title: ACTION with nifedipine GITS
(Adalat XL) provides evidence for safety and
improved outcome in angina patients : drug
trends in cardiology
From: Cardiovascular Journal of South Africa, Vol 15, Issue 5, Sep / Oct
Published: 2004
Pages: p.249-251
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- Title: CHARM study in CHF patients
with impaired LV function reinforces benefits of
candesartan cilexetil (Atacand(R)) : drug trends
in cardiology
From: Cardiovascular Journal of South Africa, Vol 15, Issue 5, Sep / Oct
Published: 2004
Pages: p.252
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- Title: Fixed-combination therapy for
hypertension increases success rate : drug
trends in cardiology
From: Cardiovascular Journal of South Africa, Vol 15, Issue 5, Sep / Oct
Published: 2004
Pages: p.254-255
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- Title: Significant reduction in
heart attacks in patients taking Pfizer's
Lipitor : drug trends in cardiology
From: Cardiovascular Journal of South Africa, Vol 15, Issue 5, Sep / Oct
Published: 2004
Pages: p.255
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- Title: Teveten(R) (eprosartan)
reduces future risk in hypertensive stroke
patients : drug trends in cardiology
From: Cardiovascular Journal of South Africa, Vol 15, Issue 5, Sep / Oct
Published: 2004
Pages: p.255-256
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- Title: Cardio news
From: Cardiovascular Journal of South Africa, Vol 15, Issue 5, Sep / Oct
Published: 2004
Pages: p.256
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