1.0Cardiovascular Journal of Africahttps://cvja.co.za/journalrich600338<blockquote class="wp-embedded-content" data-secret="FOBoDkRKuc"><a href="https://cvja.co.za/journal/cvja-2026-006/">Association of ACE I/D and ACE (rs4343) polymorphism with MACE development in hypertensive patients</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://cvja.co.za/journal/cvja-2026-006/embed/#?secret=FOBoDkRKuc" width="600" height="338" title="“Association of ACE I/D and ACE (rs4343) polymorphism with MACE development in hypertensive patients” — Cardiovascular Journal of Africa" data-secret="FOBoDkRKuc" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script> /*! This file is auto-generated */ !function(d,l){"use strict";l.querySelector&&d.addEventListener&&"undefined"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!/[^a-zA-Z0-9]/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret="'+t.secret+'"]'),o=l.querySelectorAll('blockquote[data-secret="'+t.secret+'"]'),c=new RegExp("^https?:$","i"),i=0;i<o.length;i++)o[i].style.display="none";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute("style"),"height"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):"link"===t.message&&(r=new URL(s.getAttribute("src")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener("message",d.wp.receiveEmbedMessage,!1),l.addEventListener("DOMContentLoaded",function(){for(var e,t,s=l.querySelectorAll("iframe.wp-embedded-content"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute("data-secret"))||(t=Math.random().toString(36).substring(2,12),e.src+="#?secret="+t,e.setAttribute("data-secret",t)),e.contentWindow.postMessage({message:"ready",secret:t},"*")},!1)))}(window,document); //# sourceURL=https://cvja.co.za/journal/wp-includes/js/wp-embed.min.js </script> Cardiovascular diseases remain a leading cause of morbidity and mortality worldwide. The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and ACE rs4343 polymorphism have been considered important and extensively studied for their association with cardiovascular conditions. This study investigates the association of this variant with the development of major adverse cardiovascular events (MACE) in hypertensive patients of Khyber Pakhtunkhwa, Pakistan.