{"id":4317,"date":"2025-04-24T15:28:48","date_gmt":"2025-04-24T13:28:48","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=4317"},"modified":"2025-06-09T18:45:27","modified_gmt":"2025-06-09T16:45:27","slug":"cvja-2023-036","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2023-036\/","title":{"rendered":"The relationship between serum osteoprotegerin levels and right atrial and ventricular speckle-tracking measurements in essential hypertension patients with normal left ventricular systolic function"},"content":{"rendered":"    <div id=\"article\">                                                                                                                        \r\n        <div id=\"title-container\">                                                                                                    \r\n        <div id=\"authors-title\">                                                                                                            \r\n        <!--Aurthors under Title-->                                                                                                            \r\n            Ender Emre, Ezgi Kalayc\u0131o\u011flu, Ahmet \u00d6zderya, Murat G\u00f6khan Yerlikaya, Turhan Turan, Kaan Hanc\u0131, Tayyar G\u00f6kdeniz, Mustafa \u00c7etin\r\n                                                                                                            \r\n        <\/div>        \r\n<\/div>                                                                                                                            \r\n            <div id=\"copyright\">\r\n        <strong>Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n        of Cardiovascular Journal of Africa.<\/div>\r\n    <div style=\"clear: both;\"><\/div>                                                                                                                                \r\n        <div id=\"article-abstract\">                                                                                                            \r\n            <div id=\"abstract-title\">                                                                                                        \r\n                    Abstract                                                                                                                \r\n                <\/div>                                                                                                                        \r\n                                                                                                                                \r\n            <div id=\"abstract-content\">                                                                                                        \r\n            <!--Content of Abstract Article-->                                                                                                \r\n            <!--<strong>\"Abstract titles\":<\/strong>-->                                                                                        \r\n            <!--<br\/> at the end of each section!!-->                                                                                        \r\n                                                                                                                                            \r\n        <strong>Objective:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n        We planned to reveal the relationship between OPG (osteoprotegerin) level and right heart function in hypertensive patients with normal ejection fraction, using strain analysis, which is a sensitive method in demonstrating subclinical dysfunction.                                                                                                                    \r\n                <br \/>    \r\n                \r\n                                                                                                                                                \r\n        <strong>Methods:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n        Between February and June 2018, 625 consecutive patients with a diagnosis of hypertension who applied to the cardiology out-patient clinic of our hospital were evaluated for our study and 175 eligible patients were included. The patients were divided into two groups according to their OPG level. Strain analysis was performed in the echocardiographic evaluation.                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n        <strong>Results:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n        The mean OPG value was 6.33 \u00b1 1.87 pg\/l. There were 93 patients (age 51.1 \u00b1 8.5 years) in the low OPG group and 82 patients (age 54.6 \u00b1 10.4 years) in the high OPG group. A significant difference was found between the two groups with regard to age (p = 0.016), statin use (p = 0.026), C-reactive protein level (p = 0.048), office systolic blood pressure (SBP) (p = 0.001) and office diastolic blood pressure (DBP) (p = 0.001). A significant difference was found between values of strain during reservoir phase (RASr) (p = 0.01), strain during conduit phase (RAScd) (p &lt; 0.001) and peak strain rate during reservoir phase (pRASRcd) (p = 0.044). In multivariate regression analysis, age (OR: 1.162, 95% CI: 1.064\u20131.269, p = 0.001), office DBP (OR: 1.089, 95% CI: 1.020\u20131.161, p = 0.011) and RAScd (OR: 0.890, 95% CI: 0.815\u20130.972, p &lt; 0.010) were found to be independent predictors of high OPG.\r\n                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n        <strong>Conclusion:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n         In our study, we found high OPG level was inversely correlated with right atrial strain values and linearly associated with high blood pressure. In order to take advantage of the negative indicators of high OPG, positive results can be obtained in strain values of the right heart by indirectly reducing the afterload of the right heart. This can be done by reducing high systemic blood pressure and providing tight blood pressure control.                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n            <\/div>                                                                                                                            \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                        \r\n                                                                                                                                                \r\n        <div id=\"keywords\">                                                                                                                    \r\n                                                                                                                                            \r\n            <strong>Keywords:<\/strong>                                                                                                        \r\n                                                                                                                                            \r\n            <strong>osteoprotegerin, hypertension, strain, right heart function<\/strong>                                                                                                                                                                                                                    \r\n                                                                                                                                                \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                                \r\n    <div id=\"publish-info\">                                                                                                                    \r\n                                                                                                                                \r\n    <strong>Submitted:<\/strong> April 1, 2023;<!--Month day, year; -->    \r\n    <strong>Accepted:<\/strong> July 4, 2023;<!--Month day, year; -->        \r\n    <strong>Published Online First:<\/strong> July 27, 2023;<!--Month day, year; -->                                                                        \r\n    <strong>Published:<\/strong> December 15, 2024<!--Month day, year; -->                                                                                                                                       <br \/>                                                 \r\n        <em>Cardiovasc J Afr 2024; <b>35<\/b>: 234-239<!--pg no. till pg no. \"eg. 4-7\"--><\/em>\r\n        <br \/><strong>Volume 35, Issue 4<\/strong> <br \/>    \r\n                                                                        \r\n        <\/div>                                                                                                                            \r\n                                                                                                                                        \r\n    <div id=\"DOI\">                                                                                                                    \r\n            DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2023-036<!--DOI number-->                                                                \r\n        <\/div>                                                                                                                            \r\n                    \r\n            <div id=\"author-affiliation\">                                                                                                \r\n                                                                                                                                        \r\n                <strong>Department of Cardiology, Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital, Trabzon, Turkey\r\n<\/strong>    <br \/>                                                                                \r\n                                                                                                                                        \r\n                Ender Emre, MD <br \/>\r\n                \r\n                Ezgi Kalayc\u0131o\u011flu, MD <br \/>\r\n                \r\n                Ahmet \u00d6zderya, MD <br \/>\r\n                \r\n                Murat G\u00f6khan Yerlikaya, MD <br \/>\r\n                \r\n                Turhan Turan, MD<br \/><br \/>                                                                            \r\n                                                                                                                                            \r\n                <strong>Department of Cardiology, Ak\u00e7aabat Ha\u00e7kal\u0131 Baba State Hospital, Trabzon, Turkey\r\n<\/strong>    <br \/>    \r\n\r\nKaan Hanc\u0131, MD <br \/><br \/>\r\n\r\n                <strong>Department of Cardiology, Hitit University Erol Ol\u00e7ok Training and Research Hospital, \u00c7orum, Turkey\r\n<\/strong>    <br \/>    \r\n\r\nTayyar G\u00f6kdeniz, MD <br \/><br \/>\r\n\r\n            <strong>Department of Cardiology, Medical Faculty, Recep Tayyip Erdo\u011fan University, Rize, Turkey\r\n<\/strong>    <br \/>    \r\n\r\nMustafa \u00c7etin, MD <br \/><br \/>\r\n                [soshsc hide=\"logged\"]\r\n                <strong>You need to be <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/member-login\/\" target=\"_blank\" rel=\"noopener\">logged in to view and download<\/a> the full text PDF version. <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/register\/\" target=\"_blank\" rel=\"noopener\">Register for a free account?<\/a><\/strong> <br \/><br \/>[\/soshsc]\r\n                \r\n                \r\n                \r\n                <\/div>\r\n    \r\n<\/div>","protected":false},"excerpt":{"rendered":"<p>We planned to reveal the relationship between OPG (osteoprotegerin) level and right heart function in hypertensive patients with normal ejection fraction, using strain analysis, which is a sensitive method in demonstrating subclinical dysfunction.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[44,95],"tags":[],"class_list":["post-4317","post","type-post","status-publish","format-standard","hentry","category-cardiovascular-topics","category-volume-35-issue-4"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The relationship between serum osteoprotegerin levels and right atrial and ventricular speckle-tracking measurements in essential hypertension patients with normal left ventricular systolic function - Cardiovascular Journal of Africa<\/title>\n<meta name=\"description\" content=\"We planned to reveal the relationship between OPG 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