{"id":4344,"date":"2025-04-25T11:32:06","date_gmt":"2025-04-25T09:32:06","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=4344"},"modified":"2025-06-09T18:39:01","modified_gmt":"2025-06-09T16:39:01","slug":"cvja-2023-048","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2023-048\/","title":{"rendered":"A novel U-shaped relationship between serum klotho and abdominal aortic calcification in the general population"},"content":{"rendered":"    <div id=\"article\">                                                                                                                        \r\n        <div id=\"title-container\">                                                                                                    \r\n        <div id=\"authors-title\">                                                                                                            \r\n        <!--Aurthors under Title-->                                                                                                            \r\n            Na Wei, Zuolei Shi, Yan Gong                                                                                                            \r\n        <\/div>        \r\n<\/div>                                                                                                                            \r\n            <div id=\"copyright\">\r\n        <strong>Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n        of Cardiovascular Journal of Africa.<\/div>\r\n    <div style=\"clear: both;\"><\/div>                                                                                                                                \r\n        <div id=\"article-abstract\">                                                                                                            \r\n            <div id=\"abstract-title\">                                                                                                        \r\n                    Abstract                                                                                                                \r\n                <\/div>                                                                                                                        \r\n                                                                                                                                \r\n            <div id=\"abstract-content\">                                                                                                        \r\n            <!--Content of Abstract Article-->                                                                                                \r\n            <!--<strong>\"Abstract titles\":<\/strong>-->                                                                                        \r\n            <!--<br\/> at the end of each section!!-->                                                                                        \r\n                                                                                                                                            \r\n        <strong>Background:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n        Abdominal aortic calcification (AAC) is considered an independent predictor of cardiovascular morbidity and mortality. Klotho, an anti-aging gene, has cardiovascular protective effects. At present, the association between klotho and AAC in the general population is uncertain. We investigated the relationship between serum soluble \u03b1-klotho (SSKL) and AAC in 2 327 participants from the National Health and Nutrition Examination Survey.                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n        <strong>Methods:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n        To estimate the association between log-transformed SSKL (lnSSKL) and AAC, multivariate logistic regression analyses were conducted. Stratified analyses were performed to evaluated the potential modifiers. Smoothed curve fitting and generalised additive models were also performed.                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n        <strong>Results:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n        We found lnSSKL correlated negatively with AAC after adjusting for other confounders. The relationship of lnSSKL with AAC was a U-shaped curve (inflection point: 7.01 pg\/ml). On subgroup analyses, stratified by age and smoking habit, the negative correlation of lnSSKL with AAC remained in men and in the population who smoked.                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n        <strong>Conclusion:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n         Our study revealed a negative relationship between lnSSKL and AAC in the general population. This relationship showed a U-shaped curve and was influenced by age and smoking habit.                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n            <\/div>                                                                                                                            \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                        \r\n                                                                                                                                                \r\n        <div id=\"keywords\">                                                                                                                    \r\n                                                                                                                                            \r\n            <strong>Keywords:<\/strong>                                                                                                        \r\n                                                                                                                                            \r\n            <strong> abdominal aortic calcification, klotho, NHANES, cross-sectional study, U-shaped relationship<\/strong>                                                                                                                                                                                                                    \r\n                                                                                                                                                \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                                \r\n    <div id=\"publish-info\">                                                                                                                    \r\n                                                                                                                                \r\n    <strong>Submitted:<\/strong> August 24, 2023;<!--Month day, year; -->    \r\n    <strong>Accepted:<\/strong> September 15, 2023;<!--Month day, year; -->        \r\n    <strong>Published Online First:<\/strong> October 05, 2023;<!--Month day, year; -->                                                                        \r\n    <strong>Published:<\/strong> December 15, 2024<!--Month day, year; -->                                                                                                                                <br \/>                                                        \r\n        <em>Cardiovasc J Afr 2024; <b>35<\/b>: 298-303<!--pg no. till pg no. \"eg. 4-7\"--><\/em>\r\n        <br \/><strong>Volume 35, Issue 4<\/strong> <br \/>    \r\n                                                                        \r\n        <\/div>                                                                                                                            \r\n                                                                                                                                        \r\n    <div id=\"DOI\">                                                                                                                    \r\n            DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2023-048<!--DOI number-->                                                                \r\n        <\/div>                                                                                                                            \r\n                    \r\n            <div id=\"author-affiliation\">                                                                                                \r\n                                                                                                                                        \r\n                <strong>Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, Jinan, Shandong, China<\/strong>    <br \/>                                                                                \r\n                                                                                                                                                                                                                                                                                                                                                \r\n                \r\n                Na Wei, MM <br \/>    \r\n                                                                                                                                        \r\n            <\/div>                                                                                                                        \r\n                                                                                                                                                                                                                                                                                                                                                                                                    \r\n            <div id=\"author-affiliation\">                                                                                                \r\n                                                                                                                                        \r\n                <strong>Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China<\/strong>    <br \/>                                                                            \r\n                                                                                                                                        \r\n                Zuolei Shi, MM <br \/>\r\n                \r\n                <div id=\"author-affiliation\">                                                                                                \r\n                                                                                                                                        \r\n                <strong>Department of Radiology, Shandong Public Health Clinical Center and Shandong Provincial Chest Hospital, Jinan, Shandong, China<\/strong>    <br \/>                                                                            \r\n                                                                                                                                        \r\n                Yan Gong, BSc <br \/><br \/>\r\n                [soshsc hide=\"logged\"]\r\n                <strong>You need to be <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/member-login\/\" target=\"_blank\" rel=\"noopener\">logged in to view and download<\/a> the full text PDF version. <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/register\/\" target=\"_blank\" rel=\"noopener\">Register for a free account?<\/a><\/strong> <br \/><br \/>[\/soshsc]\r\n                \r\n                \r\n                \r\n                <\/div>\r\n    \r\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Abdominal aortic calcification (AAC) is considered an independent predictor of cardiovascular morbidity and mortality. Klotho, an anti-aging gene, has cardiovascular protective effects. At present, the association between klotho and AAC in the general population is uncertain. We investigated the relationship between serum soluble \u03b1-klotho (SSKL) and AAC in 2 327 participants from the National Health and Nutrition Examination Survey.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[44,95],"tags":[],"class_list":["post-4344","post","type-post","status-publish","format-standard","hentry","category-cardiovascular-topics","category-volume-35-issue-4"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A novel U-shaped relationship between serum klotho and abdominal aortic calcification in the general population - Cardiovascular Journal of Africa<\/title>\n<meta name=\"description\" content=\"Abdominal aortic calcification (AAC) is considered an independent predictor of cardiovascular morbidity and mortality. Klotho, an anti-aging gene, has cardiovascular protective effects. At present, the association between klotho and AAC in the general population is uncertain. We investigated the relationship between serum soluble \u03b1-klotho (SSKL) and AAC in 2 327 participants from the National Health and Nutrition Examination Survey.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cvja.co.za\/journal\/cvja-2023-048\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A novel U-shaped relationship between serum klotho and abdominal aortic calcification in the general population - Cardiovascular Journal of Africa\" \/>\n<meta property=\"og:description\" content=\"Abdominal aortic calcification (AAC) is considered an independent predictor of cardiovascular morbidity and mortality. Klotho, an anti-aging gene, has cardiovascular protective effects. At present, the association between klotho and AAC in the general population is uncertain. 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