{"id":4371,"date":"2025-04-29T09:51:55","date_gmt":"2025-04-29T07:51:55","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=4371"},"modified":"2025-06-09T18:33:32","modified_gmt":"2025-06-09T16:33:32","slug":"cvja-2023-058","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2023-058\/","title":{"rendered":"A novel method that can be used in both the diagnosis and treatment of peripheral arterial disease in diabetics: vibration-mediated dilation"},"content":{"rendered":"    <div id=\"article\">                                                                                                                        \r\n        <div id=\"title-container\">                                                                                                    \r\n        <div id=\"authors-title\">                                                                                                            \r\n        <!--Aurthors under Title-->                                                                                                            \r\n            Mehmet Aydogan, Omer Kumet, Alp Ozcan, Ilke Ozcan, Ahmet Tas, Sabahattin Umman                                                                                                        \r\n        <\/div>        \r\n<\/div>                                                                                                                            \r\n            <div id=\"copyright\">\r\n        <strong>Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n        of Cardiovascular Journal of Africa.<\/div>\r\n    <div style=\"clear: both;\"><\/div>                                                                                                                                \r\n        <div id=\"article-abstract\">                                                                                                            \r\n            <div id=\"abstract-title\">                                                                                                        \r\n                    Abstract                                                                                                                \r\n                <\/div>                                                                                                                        \r\n                                                                                                                                \r\n            <div id=\"abstract-content\">                                                                                                        \r\n            <!--Content of Abstract Article-->                                                                                                \r\n            <!--<strong>\"Abstract titles\":<\/strong>-->                                                                                        \r\n            <!--<br\/> at the end of each section!!-->                                                                                        \r\n                                                                                                                                            \r\n        <strong>Objective:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n        The growing incidence of diabetes and the increasing life expectancy of the diabetic population worldwide has increased the number of diabetic vascular complications occurring in cardiology practice. As current treatment and prevention methods are less effective in this patient group, there is a need for new treatment methods in this area. Exercise, which reduces metabolic and vascular problems associated with diabetes, often becomes impossible, especially in advanced-stage patients who need exercise the most. Since exercise and flow-mediated dilation (FMD) are effective by stimulating mechanotransduction mechanisms on the endothelium, it can be expected that the same mechanisms could also be stimulated by direct vibration.                                                                                                                    \r\n                <br \/>    \r\n                \r\n                                                                                                                                                \r\n        <strong>Methods:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n        In order to test this hypothesis, in this study, a group of 20 type 2 diabetes patients (11 males, age 56.80 \u00b1 11.05 years and diagnosed for 15.35 \u00b1 8.61 years) were examined via the application of FMD and vibration-mediated dilation (VMD). We performed vibration for five minutes with 20-Hz frequency and 3-mm vertical amplitude, to the same side forearm, with a 30-minute interval. Using a 10-MHz linear echo probe, brachial artery diameter and flow velocities were recorded for 10 minutes before and at two-minute intervals after the FMD and VMD applications. Then brachial artery flow and resistance were calculated at each stage.                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n        <strong>Results:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n        In the first minute after FMD and VMD applications, brachial artery diameter and flow velocities increased significantly, and vascular resistance decreased significantly. None of the corresponding FMD or VMD parameters in the first minute was different. The artery diameters in the first minute after FMD and VMD were increased by 6.04 \u00b1 5.29 and 5.49 \u00b1 5.21%, respectively. At the tenth minute, these values decreased to 1.73 \u00b1 3.21 and 2.05 \u00b1 3.31%. In the FMD series, all parameters except brachial artery diameter returned to their baseline values after the fourth minute. After VMD, all parameters also decreased after the first minute, but the recovery was much slower. At each stage after the first minute, the VMD averages were higher than the baseline value and their corresponding FMD values.\r\n                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n        <strong>Conclusion:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n         The results of this study indicated that vibration may be a powerful, long-lasting and feasible treatment option in patients with peripheral perfusion failure, developed due to diabetic macro- and microvascular complications.                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n            <\/div>                                                                                                                            \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                        \r\n                                                                                                                                                \r\n        <div id=\"keywords\">                                                                                                                    \r\n                                                                                                                                            \r\n            <strong>Keywords:<\/strong>                                                                                                        \r\n                                                                                                                                            \r\n            <strong>vibration-mediated dilation, flow-mediated dilation, diabetes mellitus, arterial haemodynamics, endothelial function, peripheral arterial disease<\/strong>                                                                                                                                                                                                                    \r\n                                                                                                                                                \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                                \r\n    <div id=\"publish-info\">                                                                                                                    \r\n                                                                                                                                \r\n    <strong>Submitted:<\/strong> September 22, 2023;<!--Month day, year; -->    \r\n    <strong>Accepted:<\/strong> November 7, 2023;<!--Month day, year; -->        \r\n    <strong>Published Online First:<\/strong> November 29, 2023;<!--Month day, year; -->                                                                        \r\n    <strong>Published:<\/strong> December 15, 2024<!--Month day, year; -->                                                                                                                                 <br \/>                                                        \r\n        <em>Cardiovasc J Afr 2024; <b>35<\/b>: 342-350<!--pg no. till pg no. \"eg. 4-7\"--><\/em>\r\n        <br \/><strong>Volume 35, Issue 4<\/strong> <br \/>    \r\n                                                                        \r\n        <\/div>                                                                                                                            \r\n                                                                                                                                        \r\n    <div id=\"DOI\">                                                                                                                    \r\n            DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2023-058<!--DOI number-->                                                                \r\n        <\/div>                                                                                                                            \r\n                    \r\n            <div id=\"author-affiliation\">                                                                                                \r\n                                                                                                                                        \r\n                <strong>Bitlis Tatvan State Hospital, Ministry of Health, Bitlis, Turkey\r\n<\/strong>    <br \/>                                                                                \r\n                                                                                                                                        \r\n                \r\n                Mehmet Aydogan, MD <br \/><br \/>\r\n                \r\n                <strong>Van Training and Research Hospital, Ministry of Health, Van, Turkey\r\n<\/strong>    <br \/>    \r\n\r\nOmer Kumet, MD <br \/><br \/>\r\n\r\n                <strong>Department of Cardiology, Faculty of Medicine, Istanbul University, Istanbul, Turkey\r\n<\/strong>    <br \/>    \r\n\r\nAlp Ozcan, MD<br \/>\r\nIlke Ozcan,MD<br \/>\r\nAhmet Tas, MD<br \/>\r\nSabahattin Umman,MD <br \/><br \/>\r\n\r\n            <strong>Goslar Asklepios Hospital, Goslar, Germany\r\n<\/strong>    <br \/>    \r\n\r\nAhmet Tas, MD <br \/><br \/>\r\n                [soshsc hide=\"logged\"]\r\n                <strong>You need to be <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/member-login\/\" target=\"_blank\" rel=\"noopener\">logged in to view and download<\/a> the full text PDF version. <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/register\/\" target=\"_blank\" rel=\"noopener\">Register for a free account?<\/a><\/strong> <br \/><br \/>[\/soshsc]\r\n                \r\n                \r\n                \r\n                <\/div>\r\n    \r\n<\/div>","protected":false},"excerpt":{"rendered":"<p>The growing incidence of diabetes and the increasing life expectancy of the diabetic population worldwide has increased the number of diabetic vascular complications occurring in cardiology practice. As current treatment and prevention methods are less effective in this patient group, there is a need for new treatment methods in this area.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[44,95],"tags":[],"class_list":["post-4371","post","type-post","status-publish","format-standard","hentry","category-cardiovascular-topics","category-volume-35-issue-4"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A novel method that can be used in both the diagnosis and treatment of peripheral arterial disease in diabetics: vibration-mediated dilation - Cardiovascular Journal of Africa<\/title>\n<meta name=\"description\" content=\"The growing incidence of diabetes and the increasing life expectancy of the diabetic population worldwide has increased the number of diabetic vascular complications occurring in cardiology practice. 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