{"id":4374,"date":"2025-04-29T11:36:01","date_gmt":"2025-04-29T09:36:01","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=4374"},"modified":"2025-06-09T18:33:13","modified_gmt":"2025-06-09T16:33:13","slug":"cvja-2023-061","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2023-061\/","title":{"rendered":"Investigation of the effects of ellagic, vanillic and rosmarinic acid on reperfusion-induced renal injury"},"content":{"rendered":"    <div id=\"article\">                                                                                                                        \r\n        <div id=\"title-container\">                                                                                                    \r\n        <div id=\"authors-title\">                                                                                                            \r\n        <!--Aurthors under Title-->                                                                                                            \r\n            Alper Gurmen, Orkut Guclu, Serhat Huseyin, Nuray Can, Eray Ozgun, Mursel Buyukadali, Adem Reyhancan, Suat Canbaz                                                                                                        \r\n        <\/div>        \r\n<\/div>                                                                                                                            \r\n            <div id=\"copyright\">\r\n        <strong>Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n        of Cardiovascular Journal of Africa.<\/div>\r\n    <div style=\"clear: both;\"><\/div>                                                                                                                                \r\n        <div id=\"article-abstract\">                                                                                                            \r\n            <div id=\"abstract-title\">                                                                                                        \r\n                    Abstract                                                                                                                \r\n                <\/div>                                                                                                                        \r\n                                                                                                                                \r\n            <div id=\"abstract-content\">                                                                                                        \r\n            <!--Content of Abstract Article-->                                                                                                \r\n            <!--<strong>\"Abstract titles\":<\/strong>-->                                                                                        \r\n            <!--<br\/> at the end of each section!!-->                                                                                        \r\n                                                                                                                                            \r\n        <strong>Introduction:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n        The aim of this study was to investigate the effects of ellagic, vanillic and rosmarinic acid on reperfusionrelated kidney damage, developed in an experimental lowerextremity ischaemia\/reperfusion (I\/R) model.                                                                                                                    \r\n                <br \/>    \r\n                \r\n                                                                                                                                                \r\n        <strong>Methods:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n        Forty-eight female Sprague-Dawley rats were divided into six groups. A median laparotomy and dissection were performed. In the I\/R group, 60 minutes of ischaemia followed by 120 minutes of reperfusion was achieved. In addition one group was given 100 mg\/kg ellagic acid, one group was given 12 mg\/kg vanillic acid, one group was given 50 mg\/ kg rosmarinic acid and one group was given all three drugs 15 minutes before clamp removal. Bilateral kidney and blood samples were taken in all groups.                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n        <strong>Results:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n        Tubular epithelial degeneration, necrosis of the tubule epithelium and vessel wall thickening were significantly higher in the I\/R group. Some parameters in the groups that were given drugs were found to be lower than in the I\/R group and close to that of the control group. Total oxidant status (TOS) and oxidative stress index (OSI) were significantly higher and total antioxidant status (TAS) was significantly lower in the I\/R group. Although not statistically significant in the groups given drugs, TAS was higher, and TOS and OSI were lower than in the I\/R group.\r\n                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n        <strong>Conclusion:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n         The antioxidant effect of ellagic, vanillic and rosmarinic acid administration may have beneficial effects on renal damage after reperfusion in acute lower-extremity ischaemia. This study is expected to provide information for future clinical trials.                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n            <\/div>                                                                                                                            \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                        \r\n                                                                                                                                                \r\n        <div id=\"keywords\">                                                                                                                    \r\n                                                                                                                                            \r\n            <strong>Keywords:<\/strong>                                                                                                        \r\n                                                                                                                                            \r\n            <strong>ischaemia\/reperfusion, renal injury, ellagic acid, vanillic acid, rosmarinic acid<\/strong>                                                                                                                                                                                                                    \r\n                                                                                                                                                \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                                \r\n    <div id=\"publish-info\">                                                                                                                    \r\n                                                                                                                                \r\n    <strong>Submitted:<\/strong> September 18, 2023;<!--Month day, year; -->    \r\n    <strong>Accepted:<\/strong> November 15, 2023;<!--Month day, year; -->        \r\n    <strong>Published Online First:<\/strong> November 29, 2023;<!--Month day, year; -->                                                                        \r\n    <strong>Published:<\/strong> December 15, 2024<!--Month day, year; -->                                                                                                                            <br \/>                                                            \r\n        <em>Cardiovasc J Afr 2024; <b>35<\/b>: 362-367<!--pg no. till pg no. \"eg. 4-7\"--><\/em>\r\n        <br \/><strong>Volume 35, Issue 4<\/strong> <br \/>    \r\n                                                                        \r\n        <\/div>                                                                                                                            \r\n                                                                                                                                        \r\n    <div id=\"DOI\">                                                                                                                    \r\n            DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2023-061<!--DOI number-->                                                                \r\n        <\/div>                                                                                                                            \r\n                    \r\n            <div id=\"author-affiliation\">                                                                                                \r\n                                                                                                                                        \r\n                <strong>Department of Cardiovascular Surgery, Medical School of Trakya University, Edirne, Turkey\r\n<\/strong>    <br \/>                                                                                \r\n                                                                                                                                        \r\n                \r\n                Alper Gurmen, MD<br \/>\r\nOrkut Guclu, MD<br \/>\r\nSerhat Huseyin, M <br \/><br \/>\r\n                \r\n                <strong>Department of Medical Pathology, Medical School of Trakya University, Edirne, Turkey\r\n<\/strong>    <br \/>    \r\n\r\nNuray Can, MD <br \/><br \/>\r\n\r\n                <strong>Department of Medical Biochemistry, Medical School of Trakya University, Edirne, Turkey\r\n<\/strong>    <br \/>    \r\n\r\nEray Ozgun, MD<br \/><br \/>\r\n\r\n            <strong>Department of Cardiovascular Surgery, Medical School of Trakya University, Edirne, Turkey\r\n<\/strong>    <br \/>    \r\n\r\nMursel Buyukadali, MD<br \/>\r\nAdem Reyhancan, MD<br \/>\r\nSuat Canbaz, MD<br \/><br \/>\r\n                 [soshsc hide=\"logged\"]\r\n                <strong>You need to be <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/member-login\/\" target=\"_blank\" rel=\"noopener\">logged in to view and download<\/a> the full text PDF version. <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/register\/\" target=\"_blank\" rel=\"noopener\">Register for a free account?<\/a><\/strong> <br \/><br \/>[\/soshsc]\r\n                \r\n                \r\n                \r\n                <\/div>\r\n    \r\n<\/div>","protected":false},"excerpt":{"rendered":"<p>The aim of this study was to investigate the effects of ellagic, vanillic and rosmarinic acid on reperfusionrelated kidney damage, developed in an experimental lowerextremity ischaemia\/reperfusion (I\/R) model. Forty-eight female Sprague-Dawley rats were divided into six groups. A median laparotomy and dissection were performed.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[44,95],"tags":[],"class_list":["post-4374","post","type-post","status-publish","format-standard","hentry","category-cardiovascular-topics","category-volume-35-issue-4"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Investigation of the effects of ellagic, vanillic and rosmarinic acid on reperfusion-induced renal injury - Cardiovascular Journal of Africa<\/title>\n<meta name=\"description\" content=\"The aim of this study was to investigate the effects of ellagic, vanillic and rosmarinic acid on reperfusionrelated kidney damage, developed in an experimental lowerextremity ischaemia\/reperfusion (I\/R) model.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cvja.co.za\/journal\/cvja-2023-061\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigation of the effects of ellagic, vanillic and rosmarinic acid on reperfusion-induced renal injury - 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