{"id":4380,"date":"2025-04-29T11:49:23","date_gmt":"2025-04-29T09:49:23","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=4380"},"modified":"2026-05-14T11:30:08","modified_gmt":"2026-05-14T09:30:08","slug":"cvja-2023-064","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2023-064\/","title":{"rendered":"Association of ratios of monocyte\/high-density lipoprotein cholesterol and neutrophil\/high-density lipoprotein cholesterol with atherosclerotic plaque type on coronary computed tomography"},"content":{"rendered":"    <div id=\"article\">                                                                                                                        \r\n        <div id=\"title-container\">                                                                                                    \r\n        <div id=\"authors-title\">                                                                                                            \r\n        <!--Aurthors under Title-->                                                                                                            \r\n            Taha Okan, Caner Topaloglu                                                                                                            \r\n        <\/div>        \r\n<\/div>                                                                                                                            \r\n            <div id=\"copyright\">\r\n        <strong>Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n        of Cardiovascular Journal of Africa.<\/div>\r\n    <div style=\"clear: both;\"><\/div>                                                                                                                                \r\n        <div id=\"article-abstract\">                                                                                                            \r\n            <div id=\"abstract-title\">                                                                                                        \r\n                    Abstract                                                                                                                \r\n                <\/div>                                                                                                                        \r\n                                                                                                                                \r\n            <div id=\"abstract-content\">                                                                                                        \r\n            <!--Content of Abstract Article-->                                                                                                \r\n            <!--<strong>\"Abstract titles\":<\/strong>-->                                                                                        \r\n            <!--<br\/> at the end of each section!!-->                                                                                        \r\n                                                                                                                                            \r\n        <strong>Objectives:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n        The monocyte\/high-density lipoprotein cholesterol (HDL-C) ratio (MHR) and neutrophil\/HDL-C ratio (NHR) are markers for inflammation and dyslipidaemia, which are important factors in atherosclerosis. Studies have linked MHR and NHR to the prediction, severity and prognosis of coronary artery disease. However, no study has explored their connection to plaque stability, specifically its calcific or soft\/mixed content.                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n        <strong>Methods:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n        Monocyte, neutrophil and HDL-C levels were examined in 99 patients who had coronary computed tomographic angiography (CTA) between January and August 2023. They were divided into three groups: a group of 42 healthy individuals (group 0) with no coronary artery plaque and an Agatson score of 0, an unstable plaque group (group 1) with 31 patients displaying mixed and\/or soft plaque on CTA, and a stable plaque group (group 2) with 26 patients showing only calcific plaque.                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n        <strong>Results:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n        White blood cell (WBC), monocyte and neutrophil counts were significantly higher in group 1 patients compared to group 0 patients (group 0: WBC = 6.31 \u00b1 0.97 \u00d7 103 cells\/ \u00b5l, monocytes = 0.40 \u00b1 0.09 \u00d7 10\u00b3 cells\/\u00b5l, neutrophils = 3.32 \u00b1 0.81 \u00d7 10\u00b3 cells\/\u00b5l; and group 1: WBC = 7.61 \u00b1 1.95 \u00d7 10\u00b3 cells\/\u00b5l, monocytes = 0.50 \u00b1 0.11 \u00d7 10\u00b3 cells\/\u00b5l, neutrophils = 4.19 \u00b1 1.36 10\u00b3 cells\/\u00b5l; p &lt; 0.05). MHR and NHR were significantly higher in group 1 patients compared to group 0 patients (group 0: MHR = 0.0079 \u00b1 0.0029, NHR = 0.063 \u00b1 0.023 and group 1: MHR = 0.0102 \u00b1 0.003, NHR = 0.085 \u00b1 0.036, p &lt; 0.05).                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n        <strong>Conclusion:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n         The significant differences in MHR and NHR between the three groups were due to the differences between groups 0 and 1. MHR and NHR were significantly higher in group 1 patients, although there was no statistically significant difference between groups 1 and 2.                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n            <\/div>                                                                                                                            \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                        \r\n                                                                                                                                                \r\n        <div id=\"keywords\">                                                                                                                    \r\n                                                                                                                                            \r\n            <strong>Keywords:<\/strong>                                                                                                        \r\n                                                                                                                                            \r\n            <strong>coronary artery disease, coronary computed tomography angiography, monocyte\/HDL-C ratio, neutrophil\/HDL-C ratio, atherosclerosis<\/strong>                                                                                                                                                                                                                    \r\n                                                                                                                                                \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                                \r\n    <div id=\"publish-info\">                                                                                                                    \r\n                                                                                                                                \r\n    <strong>Submitted:<\/strong> October 12, 2023;<!--Month day, year; -->    \r\n    <strong>Accepted:<\/strong> November 29, 2023;<!--Month day, year; -->        \r\n    <strong>Published Online First:<\/strong> January 26, 2024;<!--Month day, year; -->                                                                        \r\n    <strong>Published:<\/strong> December 15, 2024<!--Month day, year; -->                                                                                                                             <br \/>                                                           \r\n        <em>Cardiovasc J Afr 2024; <b>35<\/b>: 382-387<!--pg no. till pg no. \"eg. 4-7\"--><\/em>\r\n        <br \/><strong>Volume 35, Issue 4<\/strong> <br \/>    \r\n                                                                            \r\n        <\/div>                                                                                                                            \r\n                                                                                                                                        \r\n    <div id=\"DOI\">                                                                                                                    \r\n            DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2023-064<!--DOI number-->                                                                \r\n        <\/div>                                                                                                                            \r\n                    \r\n            <div id=\"author-affiliation\">                                                                                                \r\n                                                                                                                                        \r\n                <strong>Department of Cardiology, Kardiya Medical Center, Izmir, Turkey<\/strong>    <br \/>                                                                                \r\n                                                                                                                                        \r\n                \r\n                Taha Okan, MD <br \/>    \r\n                                                                                                                                        \r\n            <\/div>                                                                                                                        \r\n                                                                                                                                                                                                                                                                                                                                                                                                    \r\n            <div id=\"author-affiliation\">                                                                                                \r\n                                                                                                                                        \r\n                <strong>Department of Cardiology, Medicalpoint Hospital, Izmir University of Economics, Izmir, Turkey<\/strong>    <br \/>                                                                            \r\n                                                                                                                                        \r\nCaner Topaloglu, MD<br \/><br \/>\r\n                [soshsc hide=\"logged\"]\r\n                <strong>You need to be <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/member-login\/\" target=\"_blank\" rel=\"noopener\">logged in to view and download<\/a> the full text PDF version. <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/register\/\" target=\"_blank\" rel=\"noopener\">Register for a free account?<\/a><\/strong> <br \/><br \/>[\/soshsc]\r\n                \r\n                \r\n                \r\n                <\/div>\r\n    \r\n<\/div>","protected":false},"excerpt":{"rendered":"<p>The monocyte\/high-density lipoprotein cholesterol (HDL-C) ratio (MHR) and neutrophil\/HDL-C ratio (NHR) are markers for inflammation and dyslipidaemia, which are important factors in atherosclerosis. Studies have linked MHR and NHR to the prediction, severity and prognosis of coronary artery disease. However, no study has explored their connection to plaque stability, specifically its calcific or soft\/mixed content.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[44,95],"tags":[],"class_list":["post-4380","post","type-post","status-publish","format-standard","hentry","category-cardiovascular-topics","category-volume-35-issue-4"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Association of ratios of monocyte\/high-density lipoprotein cholesterol and neutrophil\/high-density lipoprotein cholesterol with atherosclerotic plaque type on coronary computed tomography - Cardiovascular Journal of Africa<\/title>\n<meta name=\"description\" content=\"The monocyte\/high-density lipoprotein cholesterol (HDL-C) ratio (MHR) and neutrophil\/HDL-C ratio (NHR) are markers for inflammation and dyslipidaemia, which are important factors in atherosclerosis. Studies have linked MHR and NHR to the prediction, severity and prognosis of coronary artery disease. However, no study has explored their connection to plaque stability, specifically its calcific or soft\/mixed content.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cvja.co.za\/journal\/cvja-2023-064\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Association of ratios of monocyte\/high-density lipoprotein cholesterol and neutrophil\/high-density lipoprotein cholesterol with atherosclerotic plaque type on coronary computed tomography - Cardiovascular Journal of Africa\" \/>\n<meta property=\"og:description\" content=\"The monocyte\/high-density lipoprotein cholesterol (HDL-C) ratio (MHR) and neutrophil\/HDL-C ratio (NHR) are markers for inflammation and dyslipidaemia, which are important factors in atherosclerosis. 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