{"id":4392,"date":"2025-04-29T12:34:41","date_gmt":"2025-04-29T10:34:41","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=4392"},"modified":"2025-06-09T18:28:04","modified_gmt":"2025-06-09T16:28:04","slug":"cvja-2024-003","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2024-003\/","title":{"rendered":"Comprehensive ABC (HbA1c, blood pressure, LDL-C) control and cardiovascular disease risk in patients with type 2 diabetes mellitus and major depressive disorder in a South African managed healthcare organisation"},"content":{"rendered":"
\r\n
\r\n
\r\n \r\n Lovina A Naidoo, Neil Butkow, Paula Barnard-Ashton, Elena Libhaber\r\n \r\n <\/div> \r\n<\/div> \r\n
\r\n Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n of Cardiovascular Journal of Africa.<\/div>\r\n
<\/div> \r\n
\r\n
\r\n Abstract \r\n <\/div> \r\n \r\n
\r\n \r\n \r\n \r\n \r\n Aim:<\/strong> \r\n \r\n Patients with type 2 diabetes mellitus (T2DM) who have suboptimal control of the triad of glucose (A), blood pressure (B) and lipid profile (C) have an increased risk of cardiovascular disease (CVD). Additionally, the presence of major depressive disorder (MDD) can lead to poor outcomes. Therefore, the aim of this study was to assess the role of MDD with ABC control in patients with T2DM in a South African private healthcare setting. \r\n
\r\n \r\n Methods:<\/strong> \r\n \r\n Healthcare medical claims and electronic health records of 1 211 adult patients with T2DM and\/or MDD were analysed for 2019.\r\n \r\n
\r\n \r\n Results:<\/strong> \r\n \r\n Only 24% of the T2DM +\/\u2013 MDD patients reached a low-density lipoprotein cholesterol (LDL-C) target < 1.8 mmol\/l, and only 13% of the T2DM + MDD and 7.1% of T2DM \u2013 MDD patients achieved simultaneous ABC targets. The proportion of patients admitted due to macrovascular complications was higher in the T2DM + MDD group (22.8%) compared to the T2DM \u2013 MDD (13.1%) and MDD group (9.9%) (p = 0.012). Multivariate logistic regression analysis showed that older patients with T2DM + MDD achieved better glycated haemoglobin and LDL-C control. Significantly more patients with T2DM + MDD (12%) had repeat macrovascular admissions in 2019 compared to the T2DM \u2013 MDD patients (2.9%) (p = 0.005). \r\n
\r\n \r\n Conclusion:<\/strong> \r\n \r\n Despite a managed-care environment, the comprehensive ABC control among patients with T2DM was suboptimal, particularly in those with MDD, placing them at greater risk for CVD events. \r\n
\r\n \r\n <\/div> \r\n <\/div> \r\n \r\n \r\n
\r\n \r\n Keywords:<\/strong> \r\n \r\n type 2 diabetes mellitus (T2DM), major depressive disorder (MDD), cardiovascular disease (CVD), ABC control, glycated haemoglobin (HbA1c), systolic blood pressure (SBP), low-density lipoprotein cholesterol (LDL-C), managed healthcare<\/strong> \r\n \r\n <\/div> \r\n \r\n
\r\n \r\n Submitted:<\/strong> August 25, 2023; \r\n Accepted:<\/strong> February 7, 2024; \r\n Published Online First:<\/strong> March 25, 2024; \r\n Published:<\/strong> December 15, 2024
\r\n Cardiovasc J Afr 2024; 35<\/b>: 402-411<\/em>\r\n
Volume 35, Issue 4<\/strong>
\r\n \r\n <\/div> \r\n \r\n
\r\n DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2024-003 \r\n <\/div> \r\n \r\n
\r\n \r\n Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa<\/strong>
\r\n \r\nLovina A Naidoo, M Pharm, PhD
\r\nNeil Butkow, MSc (Physiology), PhD
\r\n \r\n <\/div> \r\n \r\n
\r\n \r\n School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa<\/strong>
\r\n \r\n Paula Barnard-Ashton, MSc OT, PhD
\r\n \r\n <\/div> \r\n \r\n
\r\n \r\n Health Sciences Research Office, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa<\/strong>
\r\n \r\n Elena Libhaber, MSc, PhD

\r\n [soshsc hide=\"logged\"]\r\n You need to be logged in to view and download<\/a> the full text PDF version. Register for a free account?<\/a><\/strong>

[\/soshsc]\r\n \r\n \r\n \r\n <\/div>\r\n \r\n<\/div>","protected":false},"excerpt":{"rendered":"

Patients with type 2 diabetes mellitus (T2DM) who have suboptimal control of the triad of glucose (A), blood pressure (B) and lipid profile (C) have an increased risk of cardiovascular disease (CVD). Additionally, the presence of major depressive disorder (MDD) can lead to poor outcomes. Therefore, the aim of this study was to assess the role of MDD with ABC control in patients with T2DM in a South African private healthcare setting. <\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[44,95],"tags":[],"class_list":["post-4392","post","type-post","status-publish","format-standard","hentry","category-cardiovascular-topics","category-volume-35-issue-4"],"yoast_head":"\nComprehensive ABC (HbA1c, blood pressure, LDL-C) control and cardiovascular disease risk in patients with type 2 diabetes mellitus and major depressive disorder in a South African managed healthcare organisation - Cardiovascular Journal of Africa<\/title>\n<meta name=\"description\" content=\"Patients with type 2 diabetes mellitus (T2DM) who have suboptimal control of the triad of glucose (A), blood pressure (B) and lipid profile (C) have an increased risk of cardiovascular disease (CVD). 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