{"id":4394,"date":"2025-04-29T12:38:34","date_gmt":"2025-04-29T10:38:34","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=4394"},"modified":"2025-06-09T18:25:04","modified_gmt":"2025-06-09T16:25:04","slug":"cvja-2024-006","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2024-006\/","title":{"rendered":"Evaluation of cardiac function in paediatric Wilson\u2019s disease patients with advanced echocardiographic modalities (strain and strain rate echocardiography)"},"content":{"rendered":"    <div id=\"article\">                                                                                                                        \r\n        <div id=\"title-container\">                                                                                                    \r\n        <div id=\"authors-title\">                                                                                                            \r\n        <!--Aurthors under Title-->                                                                                                            \r\n            Kerem Erta\u015f, \u00d6zlem G\u00fcl, Fatma Demirba\u015f\r\n                                                                                                            \r\n        <\/div>        \r\n<\/div>                                                                                                                            \r\n            <div id=\"copyright\">\r\n        <strong>Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n        of Cardiovascular Journal of Africa.<\/div>\r\n    <div style=\"clear: both;\"><\/div>                                                                                                                                \r\n        <div id=\"article-abstract\">                                                                                                            \r\n            <div id=\"abstract-title\">                                                                                                        \r\n                    Abstract                                                                                                                \r\n                <\/div>                                                                                                                        \r\n                                                                                                                                \r\n            <div id=\"abstract-content\">                                                                                                        \r\n            <!--Content of Abstract Article-->                                                                                                \r\n            <!--<strong>\"Abstract titles\":<\/strong>-->                                                                                        \r\n            <!--<br\/> at the end of each section!!-->                                                                                        \r\n                                                                                                                                            \r\n        <strong>Objective:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n        In Wilson\u2019s disease (WD), copper accumulation in the organs and\/or damage caused by oxygen free radicals occurs due to disturbances in copper excretion. In our study, we aimed to evaluate cardiac involvement with advanced echocardiographic modalities (tissue Doppler echocardiography, strain and strain-rate echocardiography).                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n        <strong>Methods:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n        Twenty WD patients and 20 healthy children from the Pediatric Gastroenterology Department of Diyarbak\u0131r Children\u2019s Hospital were included in the study between 2022 and 2023.                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n        <strong>Results:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n        The mean age of the WD patients was 12.89 \u00b1 3.79 years. Left ventricular wall thicknesses and diameters (diastolic interventricular septum thickness, diastolic left ventricular posterior wall thickness, left ventricular end-diastolic diameter), left ventricular diastolic function parameters (E, A, E\/A, deceleration time) and left ventricular ejection fraction and tricuspid annular plane systolic excursion were similar and not statistically significantly different in the WD and control groups. Mitral lateral e\u2032, mitral septal e\u2032 and tricuspid lateral e\u2032 velocities were lower in the WD patients and statistically significantly different from the controls (p = 0.02, 0.04 and 0.005, respectively), as assessed by tissue Doppler echocardiography. Global longitudinal systolic strain was similar in the WD and control groups and no statistically significant difference was detected. Longitudinal early diastolic strain rate was lower in the WD patients and statistically significantly different (p = 0.002).                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n        <strong>Conclusion:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\n         Subclinical early diastolic dysfunction and segmental systolic dysfunction were detected in WD patients with advanced echocardiographic modalities, in addition to normal cardiac function as assessed by conventional echocardiography. Advanced echocardiographic modalities can be used in the follow up of WD patients.                                                                                                                    \r\n                <br \/>                                                                                                                            \r\n                                                                                                                                                \r\n            <\/div>                                                                                                                            \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                        \r\n                                                                                                                                                \r\n        <div id=\"keywords\">                                                                                                                    \r\n                                                                                                                                            \r\n            <strong>Keywords:<\/strong>                                                                                                        \r\n                                                                                                                                            \r\n            <strong>Wilson\u2019s disease, strain, strain-rate echocardiography<\/strong>                                                                                                                                                                                                                    \r\n                                                                                                                                                \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                                \r\n    <div id=\"publish-info\">                                                                                                                    \r\n                                                                                                                                \r\n    <strong>Submitted:<\/strong> August 6, 2023; <!--Month day, year; -->    \r\n    <strong>Accepted:<\/strong> February 20, 2024; <!--Month day, year; -->        \r\n    <strong>Published Online First:<\/strong> March 26, 2024; <!--Month day, year; -->                                                                        \r\n    <strong>Published:<\/strong> December 15, 2024<!--Month day, year; -->                                                                                                                         <br \/>                                                               \r\n        <em>Cardiovasc J Afr 2024; <b>35<\/b>: 425-430<!--pg no. till pg no. \"eg. 4-7\"--><\/em>\r\n        <br \/><strong>Volume 35, Issue 4<\/strong> <br \/>    \r\n                                                                        \r\n        <\/div>                                                                                                                            \r\n                                                                                                                                        \r\n    <div id=\"DOI\">                                                                                                                    \r\n            DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2024-006<!--DOI number-->                                                                \r\n        <\/div>                                                                                                                            \r\n                    \r\n            <div id=\"author-affiliation\">                                                                                                \r\n                                                                                                                                        \r\n                <strong>Department of Pediatric Cardiology, Diyarbakir Children\u2019s Hospital, Diyarbakir, Turkey <\/strong>    <br \/>                                                                                \r\n                                                                                                                                        \r\n    Kerem Erta\u015f, MD<br \/>\r\n\u00d6zlem G\u00fcl, MD<br \/>    \r\n                                                                                                                                        \r\n            <\/div>                                                                                                                        \r\n                                                                                                                                                                                                                                                                                                                                                                                                    \r\n            <div id=\"author-affiliation\">                                                                                                \r\n                                                                                                                                        \r\n                <strong>Department of Pediatric Gastroenterology, Hepatology and Nutrition, Diyarbakir Children\u2019s Hospital, Diyarbak\u0131r, Turkey<\/strong>    <br \/>                                                                            \r\nFatma Demirba\u015f, MD<br \/><br \/>\r\n                [soshsc hide=\"logged\"]\r\n                <strong>You need to be <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/member-login\/\" target=\"_blank\" rel=\"noopener\">logged in to view and download<\/a> the full text PDF version. <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/register\/\" target=\"_blank\" rel=\"noopener\">Register for a free account?<\/a><\/strong> <br \/><br \/>[\/soshsc]\r\n                \r\n                \r\n                \r\n                <\/div>\r\n    \r\n<\/div>","protected":false},"excerpt":{"rendered":"<p>In Wilson\u2019s disease (WD), copper accumulation in the organs and\/or damage caused by oxygen free radicals occurs due to disturbances in copper excretion. In our study, we aimed to evaluate cardiac involvement with advanced echocardiographic modalities (tissue Doppler echocardiography, strain and strain-rate echocardiography).<\/p>\n","protected":false},"author":4,"featured_media":2391,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[44,95],"tags":[],"class_list":["post-4394","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cardiovascular-topics","category-volume-35-issue-4"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Evaluation of cardiac function in paediatric Wilson\u2019s disease patients with advanced echocardiographic modalities (strain and strain rate echocardiography) - Cardiovascular Journal of Africa<\/title>\n<meta name=\"description\" content=\"In Wilson\u2019s disease (WD), copper accumulation in the organs and\/or damage caused by oxygen free radicals occurs due to disturbances in copper excretion. In our study, we aimed to evaluate cardiac involvement with advanced echocardiographic modalities (tissue Doppler echocardiography, strain and strain-rate echocardiography).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cvja.co.za\/journal\/cvja-2024-006\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Evaluation of cardiac function in paediatric Wilson\u2019s disease patients with advanced echocardiographic modalities (strain and strain rate echocardiography) - Cardiovascular Journal of Africa\" \/>\n<meta property=\"og:description\" content=\"In Wilson\u2019s disease (WD), copper accumulation in the organs and\/or damage caused by oxygen free radicals occurs due to disturbances in copper excretion. 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