{"id":4980,"date":"2025-07-08T10:28:54","date_gmt":"2025-07-08T08:28:54","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=4980"},"modified":"2025-07-08T10:28:54","modified_gmt":"2025-07-08T08:28:54","slug":"cvja-2025-010","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2025-010\/","title":{"rendered":"Angiotensin converting enzyme gene polymorphism in Nigerians with peripartum cardiomyopathy"},"content":{"rendered":"
\r\n
\r\n
\r\n \r\n Fatima Muhammed Bashir, Isa Abubakar Aliyu, Imam Malik Kabir, Shaheeda Labaran Farouk, Hadiza Sa\u2019idu, Kamilu Musa Karaye \r\n <\/div> \r\n<\/div> \r\n
\r\n Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n of Cardiovascular Journal of Africa.<\/div>\r\n
<\/div> \r\n
\r\n
\r\n Abstract \r\n <\/div> \r\n \r\n
\r\n \r\n \r\n \r\n \r\n Introduction:<\/strong> \r\n \r\n This study aimed to determine the association between angiotensin converting enzyme (ACE) gene I\/D polymorphism and peripartum cardiomyopathy (PPCM) in Kano, Nigeria. \r\n
\r\n \r\n Methods:<\/strong> \r\n \r\n 50 PPCM patients were consecutively recruited and compared with 50 apparently healthy puerperal women as controls, in Aminu Kano Teaching Hospital, Kano, Nigeria. ACE genotyping was done by polymerase chain reaction method, after obtaining written informed consent. \r\n
\r\n \r\n Results:<\/strong> \r\n \r\n There was no significant difference in the prevalence of ACE ID and DD genotypes in the PPCM patients versus controls (44.0% vs 36.0%, p = 0.414; and 36.0% versus 40.0%, p = 0.680, respectively). Importantly, the association between ACE gene polymorphism and PPCM was not statistically significant (odds ratio: 1.46, 95% confidence interval: 0.52-4.17; p = 0.477). \r\n
\r\n \r\n Conclusion:<\/strong> \r\n \r\n The prevalence of ACE gene I\/D polymorphism was not significantly different between PPCM patients and controls. ACE gene I\/D polymorphism was not associated with PPCM in Kano, Nigeria. \r\n
\r\n \r\n <\/div> \r\n <\/div> \r\n \r\n \r\n
\r\n \r\n Keywords:<\/strong> \r\n \r\n peripartum cardiomyopathy, ACE gene polymorphism, Nigeria<\/strong> \r\n \r\n <\/div> \r\n \r\n
\r\n \r\n Submitted:<\/strong> May 29, 2024; \r\n Accepted:<\/strong> December 9, 2024; \r\n Published:<\/strong> June 30, 2025
\r\n Cardiovasc J Afr 2025; 36<\/b>: 122-128<\/em>\r\n
Volume 36, Issue 2<\/strong>
\r\n <\/div> \r\n \r\n
\r\n DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2025-010 \r\n <\/div> \r\n \r\n\t\t\t\t\t\t\t\t
\r\n \r\n Department of Medicine, Muhammad Abdullahi Wase Teaching Hospital, Kano, Nigeria<\/strong>
\r\n \r\n Fatima Muhammed Bashir
\r\n \r\n <\/div> \r\n\t\t\t\t\r\n\t\t\t\t
\r\n \r\n Department of Medical Laboratory Science, Bayero University Kano, Kano, Nigeria<\/strong>
\r\n \r\n Isa Abubakar Aliyu
\r\nImam Malik Kabir
\r\n \r\n <\/div> \r\n \r\n
\r\n \r\n Department of Community Medicine, Bayero University Kano, Kano, Nigeria<\/strong>
\r\n \r\n Shaheeda Labaran Farouk
\r\n \r\n <\/div> \r\n \r\n
\r\n \r\n Department of Medicine, Bayero University and Muhammad Abdullahi Wase Teaching Hospital, Kano, Nigeria<\/strong>
\r\n \r\n Hadiza Sa\u2019idu
\r\n\t\t\t\t\r\n\t\t\t\t
\r\n \r\n Department of Medicine, Bayero University and Aminu Kano Teaching Hospital, Kano, Nigeria<\/strong>
\r\n \r\n Kamilu Musa Karaye

\r\n\r\n [soshsc hide=\"logged\"]\r\n You need to be logged in to view and download<\/a> the full text PDF version. Register for a free account?<\/a><\/strong>

[\/soshsc]\r\n \r\n \r\n \r\n <\/div>\r\n \r\n<\/div>","protected":false},"excerpt":{"rendered":"

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