{"id":5086,"date":"2025-09-03T10:45:06","date_gmt":"2025-09-03T08:45:06","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=5086"},"modified":"2026-05-05T13:31:51","modified_gmt":"2026-05-05T11:31:51","slug":"cvja-2025-030","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2025-030\/","title":{"rendered":"Protective effects of montelukast against doxorubucin-induced cardiotoxicity in rats"},"content":{"rendered":"
\r\n
\r\n
\r\n \r\n \r\n\r\nOlcay Murat Disli, Mehmet Cengiz Colak, Mehmet Ediz Sarihan, Alaadin Polat, Nigar Vardi, Yilmaz Omur Otlu, Hakan Parlakpinar \r\n <\/div> \r\n<\/div> \r\n
\r\n Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n of Cardiovascular Journal of Africa.<\/div>\r\n
<\/div> \r\n
\r\n
\r\n Abstract \r\n <\/div> \r\n \r\n
\r\n \r\n \r\n \r\n \r\n Background:<\/strong> \r\n \r\n We investigated possible protective effect of montelukast (MTL) on doxorubicin (DOX)-induced cardiac damage in a rat model. \r\n
\r\n \r\n Methods:<\/strong> \r\n \r\n Thirty-five rats were randomised into 5 equal groups including 7 rats in each group: Control (C) group; MTL group (10 mg\/kg MTL via the orogastric route for 10 days); DOX group (single dose of 20 mg\/kg DOX intraperitoneally (i.p); DOX+MTL group (3 days after the single dose of 20 mg\/kg DOX i.p., 10 mg\/kg MTL continued for 10 days via the orogastric route); and MTL+DOX group (10 mg\/kg MTL continued for 10 days via the orogastric route, single dose 20 mg\/kg DOX administrated after last dose MTL). \r\n
\r\n\t\t\t\t\r\n\t\t\t\tResults:<\/strong> \r\n \r\n In the MTL + DOX group, a significant decrease in mean arterial blood pressure (MBP) and a marked reduction in oxygen saturation were observed together. On ECG, QT interval indicated a significant increase in DOX group compared to MTL group and a significant increase in MTL+DOX group, compared to C and MTL groups. DOX treatment led to significant increase in MDA levels, decrease in SOD levels, and increase in MPO activities in the heart and aorta tissue. Myocyte degeneration seen in DOX group significantly reduced in the MTL+DOX and DOX+MTL groups histopathologicaly. \r\n
\r\n \r\n \r\n Conclusion:<\/strong> \r\n \r\n Our results indicate that MTL has protective effects against DOX-induced cardiotoxicity in rats. \r\n
\r\n\r\n \r\n <\/div> \r\n <\/div> \r\n \r\n \r\n
\r\n \r\n Keywords:<\/strong> \r\n \r\n Montelukast, doxorubicin, cardiotoxicity, rat<\/strong> \r\n \r\n <\/div> \r\n \r\n
\r\n \r\n Submitted:<\/strong> October 10, 2024; \r\n Accepted:<\/strong> November 26, 2024; \r\n Published:<\/strong> September 3, 2025
\r\n Cardiovasc J Afr 2025; 36<\/b>: 220-228<\/em>\r\n
Volume 36, Issue 3<\/strong>
\r\n <\/div> \r\n \r\n
\r\n DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2025-030 \r\n <\/div> \r\n \r\n\t\t\t\t
\r\n \r\n Inonu University, Faculty of Medicine, Department of Cardiovascular Surgery, Malatya, T\u00dcRK\u0130YE\r\n<\/strong>
\r\n\t\t\t\tOlcay Murat Disli
\r\nMehmet Cengiz Colak
\r\nYilmaz Omur Otlu\r\n

\r\n\r\n Inonu University, Faculty of Medicine, Department of Emergency Medicine, Malatya, T\u00dcRK\u0130YE\r\n<\/strong>
\r\nMehmet Ediz Sarihan\r\n

\r\n\r\n Inonu University, Faculty of Medicine, Department of Physiology, Malatya, TURKEY\r\n<\/strong>
\r\n\t\t\t\tAlaadin Polat\r\n

\r\n\r\n Inonu University, Faculty of Medicine, Department of Histology and Embryology, Malatya, T\u00dcRK\u0130YE\r\n<\/strong>
\r\n\t\t\t\tNigar Vardi\r\n

\r\n\r\n Inonu University, Faculty of Medicine, Department of Pharmacology, Malatya, T\u00dcRK\u0130YE\r\n\r\n<\/strong>
\r\nHakan Parlakpinar\r\n\r\n

\r\n \r\n\r\n [soshsc hide=\"logged\"]\r\n You need to be logged in to view and download<\/a> the full text PDF version. Register for a free account?<\/a><\/strong>

[\/soshsc]\r\n \r\n \r\n \r\n <\/div>\r\n \r\n<\/div>","protected":false},"excerpt":{"rendered":"

The degree of hypothermia during coronary artery bypass grafting (CABG) surgery may affect kidney injury. In this study we compared the effects of mild (MLD) and moderate (MOD) hypothermia on renal injury evaluated with Neutrophil Gelatinase Associated Lipocalin (NGAL), Cystatin-C (Cyc-C) and Near Infrared Spectroscopy (NIRS) in CABG surgery.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[44,107],"tags":[],"class_list":["post-5086","post","type-post","status-publish","format-standard","hentry","category-cardiovascular-topics","category-volume-36-issue-3"],"yoast_head":"\nProtective effects of montelukast against doxorubucin-induced cardiotoxicity in rats - Cardiovascular Journal of Africa<\/title>\n<meta name=\"description\" content=\"The degree of hypothermia during coronary artery bypass grafting (CABG) surgery may affect kidney injury. In this study we compared the effects of mild (MLD) and moderate (MOD) hypothermia on renal injury evaluated with Neutrophil Gelatinase Associated Lipocalin (NGAL), Cystatin-C (Cyc-C) and Near Infrared Spectroscopy (NIRS) in CABG surgery.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cvja.co.za\/journal\/cvja-2025-030\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Protective effects of montelukast against doxorubucin-induced cardiotoxicity in rats - Cardiovascular Journal of Africa\" \/>\n<meta property=\"og:description\" content=\"The degree of hypothermia during coronary artery bypass grafting (CABG) surgery may affect kidney injury. In this study we compared the effects of mild (MLD) and moderate (MOD) hypothermia on renal injury evaluated with Neutrophil Gelatinase Associated Lipocalin (NGAL), Cystatin-C (Cyc-C) and Near Infrared Spectroscopy (NIRS) in CABG surgery.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cvja.co.za\/journal\/cvja-2025-030\/\" \/>\n<meta property=\"og:site_name\" content=\"Cardiovascular Journal of Africa\" \/>\n<meta property=\"article:published_time\" content=\"2025-09-03T08:45:06+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-05T11:31:51+00:00\" \/>\n<meta name=\"author\" content=\"Jaco Moolman\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jaco Moolman\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cvja.co.za\/journal\/cvja-2025-030\/\",\"url\":\"https:\/\/cvja.co.za\/journal\/cvja-2025-030\/\",\"name\":\"Protective effects of montelukast against doxorubucin-induced cardiotoxicity in rats - Cardiovascular Journal of Africa\",\"isPartOf\":{\"@id\":\"https:\/\/cvja.co.za\/journal\/#website\"},\"datePublished\":\"2025-09-03T08:45:06+00:00\",\"dateModified\":\"2026-05-05T11:31:51+00:00\",\"author\":{\"@id\":\"https:\/\/cvja.co.za\/journal\/#\/schema\/person\/6bf8a30a039e93fd8112db707affb920\"},\"description\":\"The degree of hypothermia during coronary artery bypass grafting (CABG) surgery may affect kidney injury. 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