{"id":5184,"date":"2025-10-09T09:09:54","date_gmt":"2025-10-09T07:09:54","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=5184"},"modified":"2026-05-05T13:30:08","modified_gmt":"2026-05-05T11:30:08","slug":"cvja-2025-035","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2025-035\/","title":{"rendered":"Secondary prevention and management of dyslipidaemia in patients with coronary artery disease on statin therapy in a tertiary academic centre in Johannesburg"},"content":{"rendered":"
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\r\n \r\n \r\nPatience Ntila, Dineo Mpanya, Nqoba Tsabedze \r\n <\/div> \r\n<\/div> \r\n
\r\n Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n of Cardiovascular Journal of Africa.<\/div>\r\n
<\/div> \r\n
\r\n
\r\n Abstract \r\n <\/div> \r\n \r\n
\r\n \r\n \r\n \r\n \r\nOptimal low-density lipoprotein cholesterol (LDL-C) control in patients with established atherosclerotic cardiovascular disease (ASCVD) is defined as LDL-C levels less than 1.4 mmol\/L and a reduction of >50% in baseline LDL-C levels. This study aims to assess LDL-C control in patients with ASCVD on statin treatment in a tertiary academic hospital. We conducted a cross-sectional study on patients with ASCVD on statin therapy and compared LDL-C levels at the time of presentation with coronary syndromes with the most recent LDL-C obtained during follow-up visits. There were 458 patients with coronary syndromes. After a median duration of 17 months (interquartile range [IQR]: 7-31), 93 (20.3%) patients had optimal LDL-C control. A history of previous coronary artery disease or stroke (odds ratio [OR]: 1.73; 95% confidence interval [CI]: 1.05\u20132.85; p = 0.031) increased the risk of poor LDL-C control. Only 20.3% of patients with ASCVD on statins achieved the guideline-recommended LDL-C target.\r\n
\r\n\r\n \r\n <\/div> \r\n <\/div> \r\n \r\n \r\n
\r\n \r\n Keywords:<\/strong> \r\n \r\n low-density lipoproteins, cholesterol, dyslipidaemia, coronary artery disease, Africa<\/strong> \r\n \r\n <\/div> \r\n \r\n
\r\n \r\n Submitted:<\/strong> September 7, 2024; \r\n Accepted:<\/strong> February 17, 2025; \r\n Published:<\/strong> October 9, 2025
\r\n Cardiovasc J Afr 2025; 36<\/b>: 318-324<\/em>\r\n
Volume 36, Issue 3<\/strong>
\r\n <\/div> \r\n \r\n
\r\n DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2025-035 \r\n <\/div> \r\n \r\n
\r\n \r\n\r\n Division of Cardiology, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand and the Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa\r\n\r\n<\/strong>
\r\nPatience Ntila
\r\nDineo Mpanya
\r\nNqoba Tsabedze\r\n\r\n

\r\n \r\n\r\n [soshsc hide=\"logged\"]\r\n You need to be logged in to view and download<\/a> the full text PDF version. Register for a free account?<\/a><\/strong>

[\/soshsc]\r\n \r\n \r\n \r\n <\/div>\r\n \r\n<\/div>","protected":false},"excerpt":{"rendered":"

Optimal low-density lipoprotein cholesterol (LDL-C) control in patients with established atherosclerotic cardiovascular disease (ASCVD) is defined as LDL-C levels less than 1.4 mmol\/L and a reduction of >50% in baseline LDL-C levels. 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