{"id":5223,"date":"2025-10-18T09:38:59","date_gmt":"2025-10-18T07:38:59","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=5223"},"modified":"2026-05-05T15:59:15","modified_gmt":"2026-05-05T13:59:15","slug":"cvja-2025-079","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2025-079\/","title":{"rendered":"The role of inflammatory markers in predicting acute kidney injury after coronary artery bypass surgery: platelet-lymphocyte and neutrophil-lymphocyte ratios"},"content":{"rendered":"    <div id=\"article\">                                                                                                                        \r\n        <div id=\"title-container\">                                                                                                    \r\n        <div id=\"authors-title\">                                                                                                            \r\n        <!--Aurthors under Title-->                                                                                                            \r\n            \r\nHuseyin Gemalmaz, Y\u0131ld\u0131r\u0131m Gultekin, Alper Selim Kocaoglu, \u02d9Ibrahim Cagri Kaya, Merih Ozbayburtlu, Abdurrahman Demirel                                                                                            \r\n        <\/div>        \r\n<\/div>                                                                                                                            \r\n            <div id=\"copyright\">\r\n        <strong>Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n        of Cardiovascular Journal of Africa.<\/div>\r\n    <div style=\"clear: both;\"><\/div>                                                                                                                                \r\n        <div id=\"article-abstract\">                                                                                                            \r\n            <div id=\"abstract-title\">                                                                                                        \r\n                    Abstract                                                                                                                \r\n                <\/div>                                                                                                                        \r\n                                                                                                                                \r\n            <div id=\"abstract-content\">                                                                                                        \r\n            <!--Content of Abstract Article-->                                                                                                \r\n            <!--<strong>\"Abstract titles\":<\/strong>-->                                                                                        \r\n            <!--<br\/> at the end of each section!!-->                                                                                        \r\n                                                                                                                                            \r\n        <strong>Purpose:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\nAcute kidney injury (AKI) after coronary artery bypass grafting (CABG) surgery is a major complication. We investigated the association between platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR), which are associated with inflammation, with the development of AKI according to the Kidney Disease Improving Global Outcomes (KDIGO) 2012 criteria.\r\n<br \/>                                                                                                                            \r\n                                                                                                                                                \r\n        <strong>Methods:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\nWe retrospectively evaluated 96 patients who underwent CABG surgery between October 11, 2022 and July 31, 2024. Patients were divided into two groups: postoperative acute kidney injury (AKI) (n = 32) and non-AKI (n = 64). The diagnosis of AKI was based on changes in serum creatinine level according to KDIGO 2012 criteria.                                                                                 \r\n                <br \/>        \r\n                \r\n                <strong>Results:<\/strong>                                                                                                    \r\nIn patients who had developed acute kidney injury, several inflammatory markers were significantly increased. Preoperative PLR and NLR values were significantly higher in the AKI group when presented as median (interquartile range) (PLR: 145.8 [98.5 \u2013 183.1] vs 118.4 [89.7 \u2013 147.1], p = 0.018; and NLR: 3.8 [2.5 \u2013 5.1] vs 2.9 [2.0 - 3.8], p = 0.009). The CRP\/albumin ratio was significantly higher in the AKI group (0.21 [0.14 \u2013 0.32] vs 0.14 [0.09 \u2013 0.22], p = 0.008). ROC analysis showed moderate discriminative ability for both markers, with AUC values of 0.728 (95% CI: 0.627 - 0.829) for PLR and 0.692 (95% CI: 0.588 -0.796) for NLR. Multivariate analysis identified preoperative PLR > 132.5 as an independent predictor of AKI (OR: 2.41, 95% CI: 1.02 - 5.68, p = 0.044).\r\n                <br \/>\r\n                                                                                                                                                                                                                                                                        \r\n                                                                                                                                                \r\n        <strong>Conclusion:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\nOur findings suggest that elevated PLR and NLR values are associated with increased risk of AKI after CABG surgery. The preoperative PLR ratio with a cut-off value of 132.5 and other inflammatory ratios can be used as independent predictors of post-CABG AKI. We suggest that these easily accessible markers may provide valuable information regarding the risk of AKI development following CABG\r\n<br \/>    \r\n                                                                                                          \r\n\r\n                                                                                                                                                \r\n            <\/div>                                                                                                                            \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                                                                                                                                                        \r\n                                                                                                                                                \r\n    <div id=\"publish-info\">                                                                                                                    \r\n                                                                                                                                \r\n    <strong>Submitted:<\/strong> June 12, 2025; <!--Month day, year; -->    \r\n    <strong>Accepted:<\/strong> July 31, 2025; <!--Month day, year; -->                                                                            \r\n    <strong>Published:<\/strong> October 17, 2025<!--Month day, year; -->                                                                                                                            <br \/>                                                            \r\n        <em>Cardiovasc J Afr 2025; <b>36<\/b>: 558-567<!--pg no. till pg no. \"eg. 4-7\"--><\/em>\r\n        <br \/><strong>Volume 36, Issue 4<\/strong> <br \/>                                                                            \r\n        <\/div>                                                                                                                            \r\n                                                                                                                                        \r\n    <div id=\"DOI\">                                                                                                                    \r\n            DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2025-079<!--DOI number-->                                                                \r\n        <\/div>                                                                                                                            \r\n                \r\n                <div id=\"author-affiliation\">                                                                                                \r\n\r\n<strong>Department of Cardiovascular Surgery, EMSEY Hospital, \u0130stanbul, Turkey\r\n\r\n\r\n<\/strong>    <br \/>                                                                            \r\nHuseyin Gemalmaz\r\n\r\n\r\n<br \/><br \/>\r\n\r\n<strong>Department of Cardiovascular Surgery, Health Science University Eskisehir Health Practice and Research Hospital, Eskisehir, Turkey\r\n\r\n<\/strong>    <br \/>                                                                            \r\nY\u0131ld\u0131r\u0131m Gultekin<br \/>\r\nAlper Selim Kocaoglu<br \/>\r\n\u0130brahim Cagri Kaya\r\n\r\n<br \/><br \/>\r\n\r\n<strong>Department of Cardiovascular Surgery, Eskisehir City Hospital, Eskisehir, Turkey\r\n\r\n<\/strong>    <br \/>                                                                            \r\nMerih Ozbayburtlu<br \/>\r\nAbdurrahman Demirel\r\n\r\n<br \/><br \/>\r\n                                                                                                                                                                                                                                        \r\n\r\n                [soshsc hide=\"logged\"]\r\n                <strong>You need to be <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/member-login\/\" target=\"_blank\" rel=\"noopener\">logged in to view and download<\/a> the full text PDF version. <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/register\/\" target=\"_blank\" rel=\"noopener\">Register for a free account?<\/a><\/strong> <br \/><br \/>[\/soshsc]\r\n                \r\n                \r\n                \r\n                <\/div>\r\n    \r\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Acute kidney injury (AKI) after coronary artery bypass grafting (CABG) surgery is a major complication. We investigated the association between platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR), which are associated with inflammation, with the development of AKI according to the Kidney Disease Improving Global Outcomes (KDIGO) 2012 criteria.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[44,108],"tags":[],"class_list":["post-5223","post","type-post","status-publish","format-standard","hentry","category-cardiovascular-topics","category-volume-36-issue-4"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The role of inflammatory markers in predicting acute kidney injury after coronary artery bypass surgery: platelet-lymphocyte and neutrophil-lymphocyte ratios - Cardiovascular Journal of Africa<\/title>\n<meta name=\"description\" content=\"Acute kidney injury (AKI) after coronary artery bypass grafting (CABG) surgery is a major complication. We investigated the association between platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR), which are associated with inflammation, with the development of AKI according to the Kidney Disease Improving Global Outcomes (KDIGO) 2012 criteria.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cvja.co.za\/journal\/cvja-2025-079\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The role of inflammatory markers in predicting acute kidney injury after coronary artery bypass surgery: platelet-lymphocyte and neutrophil-lymphocyte ratios - Cardiovascular Journal of Africa\" \/>\n<meta property=\"og:description\" content=\"Acute kidney injury (AKI) after coronary artery bypass grafting (CABG) surgery is a major complication. We investigated the association between platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR), which are associated with inflammation, with the development of AKI according to the Kidney Disease Improving Global Outcomes (KDIGO) 2012 criteria.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cvja.co.za\/journal\/cvja-2025-079\/\" \/>\n<meta property=\"og:site_name\" content=\"Cardiovascular Journal of Africa\" \/>\n<meta property=\"article:published_time\" content=\"2025-10-18T07:38:59+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-05T13:59:15+00:00\" \/>\n<meta name=\"author\" content=\"Jaco Moolman\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jaco Moolman\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cvja.co.za\/journal\/cvja-2025-079\/\",\"url\":\"https:\/\/cvja.co.za\/journal\/cvja-2025-079\/\",\"name\":\"The role of inflammatory markers in predicting acute kidney injury after coronary artery bypass surgery: platelet-lymphocyte and neutrophil-lymphocyte ratios - Cardiovascular Journal of Africa\",\"isPartOf\":{\"@id\":\"https:\/\/cvja.co.za\/journal\/#website\"},\"datePublished\":\"2025-10-18T07:38:59+00:00\",\"dateModified\":\"2026-05-05T13:59:15+00:00\",\"author\":{\"@id\":\"https:\/\/cvja.co.za\/journal\/#\/schema\/person\/6bf8a30a039e93fd8112db707affb920\"},\"description\":\"Acute kidney injury (AKI) after coronary artery bypass grafting (CABG) surgery is a major complication. 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