{"id":5245,"date":"2025-10-27T10:45:52","date_gmt":"2025-10-27T08:45:52","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=5245"},"modified":"2026-05-05T14:38:42","modified_gmt":"2026-05-05T12:38:42","slug":"cvja-2025-071","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2025-071\/","title":{"rendered":"11-Year follow-up of percutaneous pulmonary valve implantation (PPVI) in central South Africa"},"content":{"rendered":"
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\r\n \r\n \r\nDhesan N. Pillay, Stephen C. Brown, Dani\u00ebl. G. Buys\r\n <\/div> \r\n<\/div> \r\n
\r\n Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n of Cardiovascular Journal of Africa.<\/div>\r\n
<\/div> \r\n
\r\n
\r\n Abstract \r\n <\/div> \r\n \r\n
\r\n \r\n \r\n \r\n \r\n Background:<\/strong> \r\n \r\nExcellent mid-term outcomes are well- established for percutaneous pulmonary valve implantation (PPVI) in treating right ventricular outflow tract (RVOT) dysfunction. Despite this success, long-term data assessing PPVI performance are limited, especially within middle- to low-income country contexts.
\r\n \r\n Objective:<\/strong> \r\n \r\nTo report on the patient characteristics and long- term outcomes after PPVI.\r\n
\r\n\r\n Methods:<\/strong> \r\n \r\nThis retrospective study describes outcomes for 31 PPVI patients treated from 2012 to 2023 at the paediatric cardiology department, Universitas Academic Hospital, Bloemfontein, South Africa.\r\n
\r\n \r\n Results:<\/strong> \r\nThe predominant underlying diagnosis was tetralogy of Fallot (n = 20, 64.5%). The primary indications for PPVI were pulmonary insufficiency (PI) (n = 15, 48.4%), followed by mixed PI and right ventricular outflow tract (RVOT) stenosis (n = 10, 32.3%), and isolated pulmonary\/RVOT stenosis (n = 6, 19.4%). Most implants (n = 22, 71%) were placed within homograft conduits. One early death occurred during the study period, yielding a procedural mortality rate of 3.2%. At 10 years, Kaplan-Meier estimated valve survival was 77%, freedom from stent fracture was 85.3%, and freedom from infective endocarditis (IE) was 81%. The annualised incidence of IE was 1.9%\r\n
\r\n \r\n \r\n Conclusion:<\/strong> \r\n \r\nThese findings contribute long-term data on PPVI outcomes from a middle-income country setting. The results demonstrate favourable durability and performance, appearing comparable to surgical pulmonary valve replacement benchmarks. However, IE remains a significant long-term complication, underscoring the potential importance of implementing and adhering to stringent prophylactic protocols.\r\n
\r\n \r\n\r\n \r\n <\/div> \r\n <\/div> \r\n \r\n \r\n
\r\n \r\n Keywords:<\/strong> \r\n \r\n percutaneous pulmonary valve implantation, valve replacement,Melody valve, Edwards valve, PPVI, South Africa<\/strong> \r\n \r\n <\/div> \r\n \r\n
\r\n \r\n Submitted:<\/strong> April 14, 2025; \r\n Accepted:<\/strong> June 11, 2025; \r\n Published:<\/strong> October 27, 2025
\r\n Cardiovasc J Afr 2025; 36<\/b>: 491-498<\/em>\r\n
Volume 36, Issue 4<\/strong>
\r\n <\/div> \r\n \r\n
\r\n DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2025-071 \r\n <\/div> \r\n \r\n
\r\n\r\nUniversitas Academic Hospital, Bloemfontein, South Africa\r\n<\/strong>
\r\nDhesan N. Pillay
\r\nStephen C. Brown
\r\nDani\u00ebl. G. Buys\r\n\r\n

\r\n \r\n\r\n [soshsc hide=\"logged\"]\r\n You need to be logged in to view and download<\/a> the full text PDF version. Register for a free account?<\/a><\/strong>

[\/soshsc]\r\n \r\n \r\n \r\n <\/div>\r\n \r\n<\/div>","protected":false},"excerpt":{"rendered":"

Excellent mid-term outcomes are well- established for percutaneous pulmonary valve implantation (PPVI) in treating right ventricular outflow tract (RVOT) dysfunction. 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