{"id":5266,"date":"2025-11-14T11:29:37","date_gmt":"2025-11-14T09:29:37","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=5266"},"modified":"2026-05-05T14:37:09","modified_gmt":"2026-05-05T12:37:09","slug":"cvja-2025-075","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2025-075\/","title":{"rendered":"Effect of metoprolol and bisoprolol on bleeding rates in patients with atrial fibrillation"},"content":{"rendered":"
\r\n
\r\n
\r\n \r\n \r\nSefa Erdi \u00d6m\u00fcr, G\u00fcl\u015fen Gen\u00e7 Tapar, \u00c7a\u011fr\u0131 Zorlu, Kay\u0131han Karaman, Ya\u011fmur Demirezen\r\n<\/div> \r\n<\/div> \r\n
\r\n Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n of Cardiovascular Journal of Africa.<\/div>\r\n
<\/div> \r\n
\r\n
\r\n Abstract \r\n <\/div> \r\n \r\n
\r\n \r\n \r\n \r\n \r\n Background:<\/strong> \r\n \r\nAtrial fibrillation (AF) is a complex disease with irregular ventricular response and tachycardia as a result of irregular and rapid contraction of the atria, with poor cardiovascular outcomes unless treated. Beta-blockers are commonly used agents in the treatment of AF. The effects of beta-blockers on bleeding continue to be evaluated.
\r\n\r\n Aim:<\/strong> \r\n \r\nBleeding is a common complication in AF. In current cases, the evaluation of bleeding contributes to the follow-up of the disease. Our study aims to evaluate the effect of beta- blockers on bleeding in patients with AF.
\r\n\r\n Method:<\/strong> \r\n \r\nThe study was conducted retrospectively, and a total of 4004 patients hospitalised in a cardiology outpatient clinic were included. The patients were divided into two groups: those using metoprolol (n = 2481) and those using bisoprolol (n = 1523). Bleeding rates were evaluated.\r\n
\r\n \r\n Results:<\/strong> \r\nBleeding events in the entire group were as follows; gastrointestinal bleeding in 164 patients (35.65%), epistaxis in 109 patients (23.69%), eye bleeding in 47 patients (10.21%), genitourinary bleeding in 39 patients (58.47%), oral bleeding in 35 patients (7.60%), subcutaneous bleeding in 28 patients (6.08%), intracranial bleeding in 19 patients (4.13%), traumatic bleeding in 16 patients (3.47%), and haemoptysis in 3 patients (0.65%). Both Bleeding Academic Research Consortium (BARC) type > 2 and BARC\u2265 3 bleeding events were significantly higher in the bisoprolol group (p < 0.001).\r\n
\r\n \r\n \r\n Conclusion:<\/strong> \r\n \r\nAccording to this study, the risk of bleeding in AF patients using metoprolol was found to be lower than in patients using bisoprolol. Accordingly, using metoprolol in AF patients seems safer.\r\n
\r\n \r\n\r\n \r\n <\/div> \r\n <\/div> \r\n \r\n \r\n
\r\n \r\n Keywords:<\/strong> \r\n \r\n atrial fibrillation, metoprolol, bisoprolol, bleeding<\/strong> \r\n \r\n <\/div> \r\n \r\n
\r\n \r\n Submitted:<\/strong> March 19, 2025; \r\n Accepted:<\/strong> July 14, 2025; \r\n Published:<\/strong> November 14, 2025
\r\n Cardiovasc J Afr 2025; 36<\/b>: 523-529<\/em>\r\n
Volume 36, Issue 4<\/strong>
\r\n <\/div> \r\n \r\n
\r\n DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2025-075 \r\n <\/div> \r\n \r\n
\r\n\r\nDepartment of Cardiology, Tokat Gaziosmanpa\u015fa University, Tokat, Turkey\r\n<\/strong>
\r\nSefa Erdi \u00d6m\u00fcr
\r\nG\u00fcl\u015fen Gen\u00e7 Tapar
\r\n\u00c7a\u011fr\u0131 Zorlu
\r\nKay\u0131han Karaman
\r\nYa\u011fmur Demirezen\r\n\r\n

\r\n \r\n\r\n [soshsc hide=\"logged\"]\r\n You need to be logged in to view and download<\/a> the full text PDF version. Register for a free account?<\/a><\/strong>

[\/soshsc]\r\n \r\n \r\n \r\n <\/div>\r\n \r\n<\/div>","protected":false},"excerpt":{"rendered":"

Atrial fibrillation (AF) is a complex disease with irregular ventricular response and tachycardia as a result of irregular and rapid contraction of the atria, with poor cardiovascular outcomes unless treated. Beta-blockers are commonly used agents in the treatment of AF. The effects of beta-blockers on bleeding continue to be evaluated.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[51,108],"tags":[],"class_list":["post-5266","post","type-post","status-publish","format-standard","hentry","category-review-articles","category-volume-36-issue-4"],"yoast_head":"\nEffect of metoprolol and bisoprolol on bleeding rates in patients with atrial fibrillation - Cardiovascular Journal of Africa<\/title>\n<meta name=\"description\" content=\"Atrial fibrillation (AF) is a complex disease with irregular ventricular response and tachycardia as a result of irregular and rapid contraction of the atria, with poor cardiovascular outcomes unless treated. Beta-blockers are commonly used agents in the treatment of AF. The effects of beta-blockers on bleeding continue to be evaluated.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cvja.co.za\/journal\/cvja-2025-075\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Effect of metoprolol and bisoprolol on bleeding rates in patients with atrial fibrillation - Cardiovascular Journal of Africa\" \/>\n<meta property=\"og:description\" content=\"Atrial fibrillation (AF) is a complex disease with irregular ventricular response and tachycardia as a result of irregular and rapid contraction of the atria, with poor cardiovascular outcomes unless treated. Beta-blockers are commonly used agents in the treatment of AF. 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