{"id":5281,"date":"2025-11-19T12:22:07","date_gmt":"2025-11-19T10:22:07","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=5281"},"modified":"2026-05-05T16:02:06","modified_gmt":"2026-05-05T14:02:06","slug":"cvja-2025-087","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2025-087\/","title":{"rendered":"Do preoperative low triiodothyronine levels affect early kidney injury after coronary artery bypass grafting? A retrospective study"},"content":{"rendered":"    <div id=\"article\">                                                                                                                        \r\n        <div id=\"title-container\">                                                                                                    \r\n        <div id=\"authors-title\">                                                                                                            \r\n        <!--Aurthors under Title-->                                                                                                            \r\n            \r\nSedat Ozcan, G\u00fcnd\u00fcz Y\u00fcm\u00fcn\r\n<\/div>        \r\n<\/div>                                                                                                                            \r\n            <div id=\"copyright\">\r\n        <strong>Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n        of Cardiovascular Journal of Africa.<\/div>\r\n    <div style=\"clear: both;\"><\/div>                                                                                                                                \r\n        <div id=\"article-abstract\">                                                                                                            \r\n            <div id=\"abstract-title\">                                                                                                        \r\n                    Abstract                                                                                                                \r\n                <\/div>                                                                                                                        \r\n                                                                                                                                \r\n            <div id=\"abstract-content\">                                                                                                        \r\n            <!--Content of Abstract Article-->                                                                                                \r\n            <!--<strong>\"Abstract titles\":<\/strong>-->                                                                                        \r\n            <!--<br\/> at the end of each section!!-->                                                                                        \r\n                                                                                                                                                     \r\n\r\n        <strong>Objective:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\nAcute kidney injury is a common complication of cardiac surgery, and factors such as advanced age, diabetes mellitus, and low left ventricular function are reported to be risk factors for the development of acute kidney injury after coronary artery bypass grafting (CABG). There are few studies in the literature reporting the relationship between preoperative low T3 syndrome and cardiac surgery-related acute kidney injury. In this study, 1 aimed to evaluate the effect of preoperative free T3 levels on early postoperative kidney injury based on glomerular filtration rate and acute kidney injury development in isolated elective on-pump coronary artery bypass grafting patients.<br \/>   \r\n\r\n        <strong>Methods:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\nThe study was conducted in our hospital on patients who underwent isolated elective on-pump CABG surgery. Patients who underwent other open-heart surgery other than CABG, patients who had previously undergone open-heart surgery, patients who underwent off-pump CABG, patients with known preoperative renal failure, patients with known thyroid disease, and patients for whom the study data were not available were excluded. Finally, a total of 183 patients included in this study were examined and compared in two groups according to their preoperative fT3 levels.\r\n<br \/>\r\n                \r\n                <strong>Results:<\/strong>                                                                                                    \r\nThe mean preoperative fT3 value was 2.06 \u00b1 0.74 in Group 1 and 2.93 \u00b1 0.53 in Group 2 (p = 0,000). The preoperative glomerular filtration rate value was 86.36 \u00b1 11.16 and 88.78 15.79 in Group 1 and Group 2, respectively (p = 0.150). Preoperative Hgb, diabetes mellitus, and age data were similar in both groups (p=0.487, p=0.936, and p=0.073, respectively). The mean glomerular filtration rate change ratio (postoperative\/preoperative glomerular filtration rate) was 0.93 \u00b1 0.13 and 1.05 \u00b1 0.56 (p = 0.437) for Groups 1 and 2, respectively.\r\n<br \/>\r\n                                                                                                                                                                                                                                                                        \r\n                                                                                                                                                \r\n        <strong>Conclusion:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\nAs a conclusion, according to the results of this study, no association was found between preoperative low fT3 and the development of postoperative acute kidney injury in on-pump coronary artery bypass grafting patients. However, we believe that further prospective studies with larger patient numbers would be beneficial to investigate the relationship between specific thyroid hormone disorders and the development of acute kidney injury after coronary artery bypass grafting.\r\n<br \/>    \r\n                                                                                                        \r\n\r\n                                                                                                                                                \r\n            <\/div>                                                                                                                            \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                        \r\n                                                                                                                                                \r\n        <div id=\"keywords\">                                                                                                                    \r\n                                                                                                                                            \r\n            <strong>Keywords:<\/strong>                                                                                                        \r\n                                                                                                                                            \r\n            <strong>coronary artery bypass surgery, thyroid hormone, mortality, kidney injury<\/strong>                                                                                                                                                                                                                    \r\n                                                                                                                                                \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                                \r\n    <div id=\"publish-info\">                                                                                                                    \r\n                                                                                                                                \r\n    <strong>Submitted:<\/strong> July 15, 2025; <!--Month day, year; -->    \r\n    <strong>Accepted:<\/strong> July 28, 2025; <!--Month day, year; -->                                                                            \r\n    <strong>Published:<\/strong> November 19, 2025<!--Month day, year; -->                                                                                                                            <br \/>                                                            \r\n        <em>Cardiovasc J Afr 2025; <b>36<\/b>: 619-623<!--pg no. till pg no. \"eg. 4-7\"--><\/em>\r\n        <br \/><strong>Volume 36, Issue 4<\/strong> <br \/>                                                                            \r\n        <\/div>                                                                                                                            \r\n                                                                                                                                        \r\n    <div id=\"DOI\">                                                                                                                    \r\n            DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2025-087<!--DOI number-->                                                                \r\n        <\/div>                                                                                                                            \r\n                \r\n                <div id=\"author-affiliation\">                                                                                                \r\n\r\n<strong>\u00c7anakkale Onsekiz Mart University Faculty of Medicine, Department of Cardiovascular Surgery, \u00c7anakkale, Turkey\r\n<\/strong>    <br \/>                                                                            \r\nSedat Ozcan\r\n\r\n<br \/><br \/>\r\n\r\n<strong>Tekirda\u011f City Hospital Department of Cardiovascular Surgery, Tekirda\u011f, Turkey\r\n<\/strong>    <br \/>                                                                            \r\nG\u00fcnd\u00fcz Y\u00fcm\u00fcn\r\n\r\n<br \/><br \/>\r\n                                                                                                                                                                                                                                        \r\n\r\n                [soshsc hide=\"logged\"]\r\n                <strong>You need to be <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/member-login\/\" target=\"_blank\" rel=\"noopener\">logged in to view and download<\/a> the full text PDF version. <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/register\/\" target=\"_blank\" rel=\"noopener\">Register for a free account?<\/a><\/strong> <br \/><br \/>[\/soshsc]\r\n                \r\n                \r\n                \r\n                <\/div>\r\n    \r\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Acute kidney injury is a common complication of cardiac surgery, and factors such as advanced age, diabetes mellitus, and low left ventricular function are reported to be risk factors for the development of acute kidney injury after coronary artery bypass grafting (CABG). There are few studies in the literature reporting the relationship between preoperative low T3 syndrome and cardiac surgery-related acute kidney injury. In this study, 1 aimed to evaluate the effect of preoperative free T3 levels on early postoperative kidney injury based on glomerular filtration rate and acute kidney injury development in isolated elective on-pump coronary artery bypass grafting patients.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[44,108],"tags":[],"class_list":["post-5281","post","type-post","status-publish","format-standard","hentry","category-cardiovascular-topics","category-volume-36-issue-4"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Do preoperative low triiodothyronine levels affect early kidney injury after coronary artery bypass grafting? A retrospective study - Cardiovascular Journal of Africa<\/title>\n<meta name=\"description\" content=\"Acute kidney injury is a common complication of cardiac surgery, and factors such as advanced age, diabetes mellitus, and low left ventricular function are reported to be risk factors for the development of acute kidney injury after coronary artery bypass grafting (CABG). There are few studies in the literature reporting the relationship between preoperative low T3 syndrome and cardiac surgery-related acute kidney injury. In this study, 1 aimed to evaluate the effect of preoperative free T3 levels on early postoperative kidney injury based on glomerular filtration rate and acute kidney injury development in isolated elective on-pump coronary artery bypass grafting patients.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cvja.co.za\/journal\/cvja-2025-087\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Do preoperative low triiodothyronine levels affect early kidney injury after coronary artery bypass grafting? A retrospective study - Cardiovascular Journal of Africa\" \/>\n<meta property=\"og:description\" content=\"Acute kidney injury is a common complication of cardiac surgery, and factors such as advanced age, diabetes mellitus, and low left ventricular function are reported to be risk factors for the development of acute kidney injury after coronary artery bypass grafting (CABG). There are few studies in the literature reporting the relationship between preoperative low T3 syndrome and cardiac surgery-related acute kidney injury. In this study, 1 aimed to evaluate the effect of preoperative free T3 levels on early postoperative kidney injury based on glomerular filtration rate and acute kidney injury development in isolated elective on-pump coronary artery bypass grafting patients.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cvja.co.za\/journal\/cvja-2025-087\/\" \/>\n<meta property=\"og:site_name\" content=\"Cardiovascular Journal of Africa\" \/>\n<meta property=\"article:published_time\" content=\"2025-11-19T10:22:07+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-05T14:02:06+00:00\" \/>\n<meta name=\"author\" content=\"Jaco Moolman\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jaco Moolman\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cvja.co.za\/journal\/cvja-2025-087\/\",\"url\":\"https:\/\/cvja.co.za\/journal\/cvja-2025-087\/\",\"name\":\"Do preoperative low triiodothyronine levels affect early kidney injury after coronary artery bypass grafting? 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