{"id":5404,"date":"2026-02-20T11:52:58","date_gmt":"2026-02-20T09:52:58","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=5404"},"modified":"2026-02-20T11:52:58","modified_gmt":"2026-02-20T09:52:58","slug":"cvja-2025-096","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2025-096\/","title":{"rendered":"The molecular effects of lepidium sativum extract on damage in rats with cardiac damage caused by total circulatory arrest"},"content":{"rendered":"    <div id=\"article\">                                                                                                                        \r\n        <div id=\"title-container\">                                                                                                    \r\n        <div id=\"authors-title\">                                                                                                            \r\n        <!--Aurthors under Title-->                                                                                                            \r\n            \r\nMurat Ziya Ba\u011f\u0131\u015f, Bi\u015far Ama\u00e7, Yasemin Hacanl\u0131, Ezhar Ers\u00f6z, Muhammet Emin G\u00fcld\u00fcr, \u0130smail Koyuncu, Kadir Egi\r\n<\/div>        \r\n<\/div>                                                                                                                            \r\n            <div id=\"copyright\">\r\n        <strong>Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n        of Cardiovascular Journal of Africa.<\/div>\r\n    <div style=\"clear: both;\"><\/div>                                                                                                                                \r\n        <div id=\"article-abstract\">                                                                                                            \r\n            <div id=\"abstract-title\">                                                                                                        \r\n                    Abstract                                                                                                                \r\n                <\/div>                                                                                                                        \r\n                                                                                                                                \r\n            <div id=\"abstract-content\">                                                                                                        \r\n            <!--Content of Abstract Article-->                                                                                                \r\n            <!--<strong>\"Abstract titles\":<\/strong>-->                                                                                        \r\n            <!--<br\/> at the end of each section!!-->                                                                                        \r\n                                                                                                                                                     \r\n\r\n        <strong>Introduction:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\nCardiovascular diseases, which are non-communicable diseases, are among the leading causes of death worldwide.\r\n<br \/>   \r\n\r\n        <strong>Objective:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\nIn this study, we aimed to investigate the efficacy of Lepidium sativum extract, which has antioxidant properties, in preventing cardiac damage in rats with cardiac damage induced by total circulatory arrest, using biochemical and histopathological methods.\r\n<br \/>\r\n\r\n        <strong>Methods:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\nTwenty-four adult male Wistar albino rats weighing 200\u2013250 g were used in our study. These rats were randomly divided into four groups. Group 1 (Control, n = 6), Group 2 (Ischaemia (TCA), n = 6), Group 3 (Treatment 1, Ischaemia + Lepidium sativum, n = 6), Group 4 (Treatment 2, Lepidium sativum, n = 6). TOS, TOS, NRF-2, TNF-\u03b1, MDA, and HIF-1\u03b1 parameters were measured in blood plasma and heart tissue using the ELISA kit method. In addition, baseline chemical parameters were examined in plasma. Histopathological examination of heart tissue was performed.\r\n<br \/>\r\n                \r\n                <strong>Results:<\/strong>                                                                                                    \r\nThere were statistically significant differences between groups in terms of plasma MDA (p < 0.001), HIF-1\u03b1 (p < 0.001), NRF-2 (p < 0.001), TAS (p < 0.001), TOS (p < 0.05), and TNF-\u03b1 (p < 0.05) levels; in heart tissue, MDA (p < 0.05), HIF-1\u03b1 (p < 0.05), NRF-2 (p < 0.05), TAS (p < 0.001), TOS (p < 0.05), and OSI (p < 0.05) parameters were found to be significant. TAS levels were highest in the LS group (p < 0.001), while TOS levels were highest in the Ischaemia group (p < 0.05).\r\n<br \/>\r\n                                                                                                                                                                                                                                                                        \r\n                                                                                                                                                \r\n        <strong>Conclusion:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\nLepidium sativum significantly improved cardiac damage in rats with TCA-induced cardiac damage by reducing MDA, HIF-1\u03b1, TNF-\u03b1, and TOS levels. In addition, histopathological examination revealed that cardiac myocytes had a more regular structure in the group administered the extract. Furthermore, we believe that this study provides valuable data in the field of cardiovascular molecular mechanisms.\r\n<br \/>    \r\n                                                                                                        \r\n\r\n                                                                                                                                                \r\n            <\/div>                                                                                                                            \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                        \r\n                                                                                                                                                \r\n        <div id=\"keywords\">                                                                                                                    \r\n                                                                                                                                            \r\n            <strong>Keywords:<\/strong>                                                                                                        \r\n                                                                                                                                            \r\n            <strong>Total Circulatory Arrest, Lepidium Sativum, Oxidative Stress and Cardiovascular Diseases<\/strong>                                                                                                                                                                                                                    \r\n                                                                                                                                                \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                                \r\n    <div id=\"publish-info\">                                                                                                                    \r\n                                                                                                                                \r\n    <strong>Submitted:<\/strong> May 17, 2025; <!--Month day, year; -->    \r\n    <strong>Accepted:<\/strong> November 5, 2025; <!--Month day, year; -->                                                                            \r\n    <strong>Published:<\/strong> February 20, 2026<!--Month day, year; -->                                                                                                                            <br \/>                                                            \r\n        <em>Cardiovasc J Afr 2025; <b>37<\/b>: 32-42<!--pg no. till pg no. \"eg. 4-7\"--><\/em>\r\n        <br \/><strong>Volume 37, Issue 1<\/strong> <br \/>                                                                            \r\n        <\/div>                                                                                                                            \r\n                                                                                                                                        \r\n    <div id=\"DOI\">                                                                                                                    \r\n            DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2025-096<!--DOI number-->                                                                \r\n        <\/div>                                                                                                                            \r\n                \r\n                <div id=\"author-affiliation\">                                                                                                \r\n\r\n\r\n<strong>Harran University, Faculty of Medicine, Department of Cardiovascular Surgery, \u015eanl\u0131urfa, Turkey\r\n<\/strong>    <br \/>                                                                            \r\nMurat Ziya Ba\u011f\u0131\u015f\r\n\r\n<br \/><br \/>\r\n\r\n<strong>Harran University, Faculty of Health Sciences, Department of Perfusion, \u015eanl\u0131urfa, Turkey\r\n<\/strong>    <br \/>                                                                            \r\nBi\u015far Ama\u00e7\r\n\r\n<br \/><br \/>\r\n\r\n<strong>Harran University, Faculty of Health Sciences, Department of Perfusion, \u015eanl\u0131urfa, Turkey\r\n<\/strong>    <br \/>                                                                            \r\nYasemin Hacanl\u0131\r\n\r\n<br \/><br \/>\r\n\r\n<strong>Harran University Hospital, Department of Cardiovascular Surgery, \u015eanl\u0131urfa, Turkey\r\n<\/strong>    <br \/>                                                                            \r\nEzhar Ers\u00f6z\r\n\r\n<br \/><br \/>\r\n\r\n<strong>Harran University, Faculty of Medicine, Department of Pathology, \u015eanl\u0131urfa, Turkey\r\n<\/strong>    <br \/>                                                                            \r\nMuhammet Emin G\u00fcld\u00fcr\r\n\r\n<br \/><br \/>\r\n\r\n<strong>Harran University, Faculty of Medicine, Department of Medical Biochemistry, \u015eanl\u0131urfa, Turkey\r\n<\/strong>    <br \/>                                                                            \r\n\u0130smail Koyuncu\r\n\r\n<br \/><br \/>\r\n\r\n<strong>Gaziantep University, Faculty of Medicine, Department of Medical Biochemistry, Gaziantep, Turkey; Harran University Vocational School of Health Services Dialysis Program, \u015eanl\u0131urfa, Turkey\r\n<\/strong>    <br \/>                                                                            \r\nKadir Egi\r\n\r\n<br \/><br \/>\r\n                                                                                                                                                                                                                                        \r\n\r\n                [soshsc hide=\"logged\"]\r\n                <strong>You need to be <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/member-login\/\" target=\"_blank\" rel=\"noopener\">logged in to view and download<\/a> the full text PDF version. <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/register\/\" target=\"_blank\" rel=\"noopener\">Register for a free account?<\/a><\/strong> <br \/><br \/>[\/soshsc]\r\n                \r\n                \r\n                \r\n                <\/div>\r\n    \r\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Cardiovascular diseases, which are non-communicable diseases, are among the leading causes of death worldwide.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[44,109],"tags":[],"class_list":["post-5404","post","type-post","status-publish","format-standard","hentry","category-cardiovascular-topics","category-volume-37-issue-1"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The molecular effects of lepidium sativum extract on damage in rats with cardiac damage caused by total circulatory arrest - Cardiovascular Journal of Africa<\/title>\n<meta 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