{"id":5583,"date":"2026-05-29T13:43:19","date_gmt":"2026-05-29T11:43:19","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=5583"},"modified":"2026-05-29T13:43:19","modified_gmt":"2026-05-29T11:43:19","slug":"cvja-2026-005","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2026-005\/","title":{"rendered":"Association between PRECISE-DAPT score and clinical outcomes: a subgroup analysis of the DAPT-TR registry"},"content":{"rendered":"    <div id=\"article\">                                                                                                                        \r\n        <div id=\"title-container\">                                                                                                    \r\n        <div id=\"authors-title\">                                                                                                            \r\n        <!--Aurthors under Title-->                                                                                                            \r\n            \r\nBerat U\u011fuz, Ahmet \u00d6z, \u00d6mer Kertmen, \u0130lyas \u00c7etin, L\u00fctf\u00fc Bekar, Ferit B\u00fcy\u00fck, Serkan Asil, Mehmet Cansel, Hakan Ta\u015folar, Mehdi Zoghi\r\n<\/div>        \r\n<\/div>                                                                                                                            \r\n            <div id=\"copyright\">\r\n        <strong>Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n        of Cardiovascular Journal of Africa.<\/div>\r\n    <div style=\"clear: both;\"><\/div>                                                                                                                                \r\n        <div id=\"article-abstract\">                                                                                                            \r\n            <div id=\"abstract-title\">                                                                                                        \r\n                    Abstract                                                                                                                \r\n                <\/div>                                                                                                                        \r\n                                                                                                                                \r\n            <div id=\"abstract-content\">                                                                                                        \r\n            <!--Content of Abstract Article-->                                                                                                \r\n            <!--<strong>\"Abstract titles\":<\/strong>-->                                                                                        \r\n            <!--<br\/> at the end of each section!!-->                                                                                        \r\n                                                                                                                                                    \r\n\r\n        <strong>Objective:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\nThis study aimed to evaluate whether a PRECISE-DAPT score \u2265 25 identifies a high-risk phenotype associated with adverse ischemic and bleeding outcomes, hospitalisation, and mortality among patients treated with fixed-dose acetylsalicylic acid and clopidogrel.\r\n<br \/>    \r\n\r\n        <strong>Methods:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\nWe conducted a prespecified subgroup analysis of the DAPT-TR registry, a prospective, multicentre observational cohort including 1,500 patients who were initiated on fixed-dose combination dual antiplatelet therapy (aspirin 75 mg\/day plus clopidogrel 75 mg\/day) for the treatment of acute and stable coronary artery disease. Patients were stratified according to PRECISE-DAPT score categories (\u2265 25 vs < 25). Six-month clinical outcomes, including all-cause and cardiovascular hospitalisation, myocardial infarction, stent thrombosis, BARC type 1 bleeding, all-cause mortality, cardiovascular mortality, and stroke, were compared between groups. Multivariable logistic regression analysis was performed to evaluate independent associations between PRECISE-DAPT score categories and clinical outcomes.\r\n<br \/>\r\n                \r\n                <strong>Results:<\/strong>                                                                                                    \r\nOf 1,500 patients, 344 (22.9%) had a PRECISE-DAPT score \u2265 25. Compared with patients with a PRECISE-DAPT score < 25, those with a PRECISE-DAPT score \u2265 25 were older (mean age 71.9 vs. 60.8 years; p < 0.001), more frequently female, and had significantly more comorbidities and reduced LVEF. At 6 months, patients with a PRECISE-DAPT score \u2265 25 experienced higher rates of all-cause hospitalisation (19.5% vs. 10.9%; p < 0.001), cardiovascular hospitalisation (11.6% vs. 6.7%; p = 0.003), stent thrombosis (2.6% vs. 1.0%; p = 0.029), and BARC type 1 bleeding (7.5% vs. 2.2%; p < 0.001). All-cause mortality (1.7% vs. 0.2%; p = 0.003) and cardiovascular mortality (1.2% vs. 0.1%; p = 0.011) were also significantly higher. After adjustment, a PRECISE-DAPT score \u2265 25 remained independently associated with mortality (OR: 3.8; 95% CI: 1.2\u201312.1) and hospitalisation (OR: 2.1; 95% CI: 1.5\u20133.1).\r\n<br \/>\r\n                                                                                                                                                                                                                                                                        \r\n                                                                                                                                                \r\n        <strong>Conclusion:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\nA PRECISE-DAPT score \u2265 25 delineates a clinically vulnerable subgroup with elevated ischemic, haemorrhagic, and mortality risks, even under uniform fixed-dose DAPT. These findings suggest that the PRECISE-DAPT score may serve as a multidimensional prognostic tool beyond bleeding risk stratification.\r\n<br \/>    \r\n                                                                                                        \r\n\r\n                                                                                                                                                \r\n            <\/div>                                                                                                                            \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                        \r\n                                                                                                                                                \r\n        <div id=\"keywords\">                                                                                                                    \r\n                                                                                                                                            \r\n            <strong>Keywords:<\/strong>                                                                                                        \r\n                                                                                                                                            \r\n            <strong>PRECISE-DAPT score, dual antiplatelet therapy, coronary artery disease, risk stratification, clopidogrel, acetylsalicylic acid<\/strong>                                                                                                                                                                                                                    \r\n                                                                                                                                                \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                                \r\n    <div id=\"publish-info\">                                                                                                                    \r\n                                                                                                                                \r\n    <strong>Submitted:<\/strong> October 12, 2025; <!--Month day, year; -->    \r\n    <strong>Accepted:<\/strong> January 28, 2026; <!--Month day, year; -->                                                                            \r\n    <strong>Published:<\/strong> May 29, 2026<!--Month day, year; -->                                                                                                                            <br \/>                                                            \r\n        <em>Cardiovasc J Afr 2025; <b>37<\/b>: 198-202<!--pg no. till pg no. \"eg. 4-7\"--><\/em>\r\n        <br \/><strong>Volume 37, Issue 2<\/strong> <br \/>                                                                            \r\n        <\/div>                                                                                                                            \r\n                                                                                                                                        \r\n    <div id=\"DOI\">                                                                                                                    \r\n            DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2026-005<!--DOI number-->                                                                \r\n        <\/div>                                                                                                                            \r\n                \r\n                <div id=\"author-affiliation\">                                                                                                \r\n\r\n\r\n<strong>Bursa City Hospital, Department of Cardiology, Bursa, Turkey\r\n\r\n<\/strong>    <br \/>                                                                            \r\nBerat U\u011fuz\r\n\r\n<br \/><br \/>   \r\n\r\n<strong>Department of Cardiology, Health Science University, \u0130stanbul Training and Research Hospital, \u0130stanbul, Turkey\r\n\r\n<\/strong>    <br \/>                                                                            \r\nAhmet \u00d6z\r\n\r\n<br \/><br \/>   \r\n\r\n<strong>Amasya University Sabuncuo\u011flu \u015eerefeddin Training and Research Hospital, Department of Cardiology, Amasya, Turkey\r\n\r\n<\/strong>    <br \/>                                                                            \r\n\u00d6mer Kertmen\r\n\r\n<br \/><br \/>   \r\n\r\n<strong>Ba\u015fak\u015fehir \u00c7am ve Sakura City Hospital, Department of Cardiology, \u0130stanbul, Turkey\r\n\r\n<\/strong>    <br \/>                                                                            \r\n\u0130lyas \u00c7etin\r\n\r\n<br \/><br \/>   \r\n\r\n<strong>Hitit University, Faculty of Medicine, Department of Cardiology, \u00c7orum, Turkey\r\n\r\n<\/strong>    <br \/>                                                                            \r\nL\u00fctf\u00fc Bekar\r\n\r\n<br \/><br \/>   \r\n\r\n<strong>Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Cardiology, \u0130stanbul, Turkey\r\n\r\n<\/strong>    <br \/>                                                                            \r\nFerit B\u00fcy\u00fck\r\n\r\n<br \/><br \/>   \r\n\r\n<strong>G\u00fclhane Training and Research Hospital, Department of Cardiology, Ankara, Turkey\r\n\r\n<\/strong>    <br \/>                                                                            \r\nSerkan Asil\r\n\r\n<br \/><br \/>   \r\n\r\n<strong>\u0130n\u00f6n\u00fc University, Faculty of Medicine, Department of Cardiology, Malatya, Turkey\r\n\r\n<\/strong>    <br \/>                                                                            \r\nMehmet Cansel<br \/> \r\nHakan Ta\u015folar\r\n\r\n<br \/><br \/>   \r\n\r\n<strong>Ege University, Department of Cardiology, \u0130zmir, Turkey\r\n\r\n<\/strong>    <br \/>                                                                            \r\nMehdi Zoghi\r\n\r\n<br \/><br \/>    \r\n\r\n                [soshsc hide=\"logged\"]\r\n                <strong>You need to be <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/member-login\/\" target=\"_blank\" rel=\"noopener\">logged in to view and download<\/a> the full text PDF version. <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/register\/\" target=\"_blank\" rel=\"noopener\">Register for a free account?<\/a><\/strong> <br \/><br \/>[\/soshsc]\r\n                \r\n                \r\n                \r\n                <\/div>\r\n    \r\n<\/div>","protected":false},"excerpt":{"rendered":"<p>This study aimed to evaluate whether a PRECISE-DAPT score \u2265 25 identifies a high-risk phenotype associated with adverse ischemic and bleeding outcomes, hospitalisation, and mortality among patients treated with fixed-dose acetylsalicylic acid and clopidogrel.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[44,110],"tags":[],"class_list":["post-5583","post","type-post","status-publish","format-standard","hentry","category-cardiovascular-topics","category-volume-37-issue-2"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Association between PRECISE-DAPT score and clinical outcomes: a subgroup analysis of the DAPT-TR registry - Cardiovascular Journal of Africa<\/title>\n<meta name=\"description\" content=\"This study aimed to evaluate whether a PRECISE-DAPT score \u2265 25 identifies a high-risk phenotype associated with adverse ischemic and bleeding 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