{"id":5637,"date":"2026-07-06T10:57:02","date_gmt":"2026-07-06T08:57:02","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=5637"},"modified":"2026-07-06T10:57:02","modified_gmt":"2026-07-06T08:57:02","slug":"cvja-2026-012","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2026-012\/","title":{"rendered":"Association between serum uric acid-to-high-density lipoprotein cholesterol ratio and myocardial bridging: a cross-sectional study"},"content":{"rendered":"
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\r\n \r\n \r\nEmirhan Hanc\u0131o\u011flu, Sevgi \u00d6zcan, \u00d6zkan Bekler, As\u0131m Enho\u015f, Ertu\u011frul Okuyan\r\n<\/div> \r\n<\/div> \r\n
\r\n Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n of Cardiovascular Journal of Africa.<\/div>\r\n
<\/div> \r\n
\r\n
\r\n Abstract \r\n <\/div> \r\n \r\n
\r\n \r\n \r\n \r\n \r\n\r\n Background:<\/strong> \r\n \r\nMyocardial bridging (MB) is a congenital coronary anomaly that is often regarded as a benign condition but may lead to adverse clinical outcomes. Systemic metabolic and inflammatory markers have been suggested as potential indicators of MB.\r\n
\r\n\r\n Objective:<\/strong> \r\n \r\nTo investigate the association between the uric acid-to-high-density lipoprotein cholesterol ratio (UHR) and the presence of MB.\r\n
\r\n\r\n Methods:<\/strong> \r\n \r\nIn this retrospective study, patients who underwent elective coronary angiography were evaluated. A total of 245 patients meeting the inclusion criteria were included. Based on angiographic findings, patients were classified into two groups: those with MB (MB[+]) and a control group with normal coronary arteries. Serum UHR, neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-HDL cholesterol ratio (MHR) were calculated. Univariate and multivariate logistic regression analyses were performed to determine independent predictors of MB. Receiver operating characteristic (ROC) curve analysis was used to evaluate the discriminative performance of inflammatory indices.\r\n
\r\n \r\n Results:<\/strong> \r\nAmong the 245 patients included in the study, 129 (52.6%) had MB. In multivariate analysis, NLR (odds ratio [OR] = 2.858, 95% confidence interval [CI]: 1.750\u20134.668, p = 0.001), MHR (OR = 1.126, 95% CI: 1.021\u20131.242, p = 0.018), and UHR (OR = 1.342, 95% CI: 1.161\u20131.552, p = 0.001) were independent predictors of MB. ROC analysis demonstrated that UHR had the highest discriminative ability for MB (AUC = 0.853, 95% CI: 0.803\u20130.902, p < 0.001), with an optimal cut-off value of 9.9, yielding 81.4% sensitivity and 80.3% specificity.\r\n
\r\n \r\n \r\n Conclusion:<\/strong> \r\n \r\nUHR is an independent predictor of MB and may serve as a useful biomarker for guiding clinical management.\r\n
\r\n \r\n\r\n \r\n <\/div> \r\n <\/div> \r\n \r\n \r\n
\r\n \r\n Keywords:<\/strong> \r\n \r\n atherosclerosis, inflammation, myocardial bridge, UHR<\/strong> \r\n \r\n <\/div> \r\n \r\n
\r\n \r\n Submitted:<\/strong> November 28, 2025; \r\n Accepted:<\/strong> February 11, 2026; \r\n Published:<\/strong> July 6, 2026
\r\n Cardiovasc J Afr 2025; 37<\/b>: 264-268<\/em>\r\n
Volume 37, Issue 3<\/strong>
\r\n <\/div> \r\n \r\n
\r\n DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2026-012 \r\n <\/div> \r\n \r\n
\r\n\r\n\r\nDepartment of Cardiology, Istanbul Medipol University, Ac\u0131badem District Hospital, Kad\u0131k\u00f6y, Istanbul\r\n\r\n<\/strong>
\r\nEmirhan Hanc\u0131o\u011flu
\r\n\u00d6zkan Bekler
\r\nAs\u0131m Enho\u015f
\r\nErtu\u011frul Okuyan\r\n

\r\n\r\nDepartment of Cardiology, Ba\u011fc\u0131lar Training and Research Hospital, Ba\u011fc\u0131lar, Istanbul\r\n\r\n<\/strong>
\r\nSevgi \u00d6zcan\r\n

\r\n \r\n\r\n [soshsc hide=\"logged\"]\r\n You need to be logged in to view and download<\/a> the full text PDF version. Register for a free account?<\/a><\/strong>

[\/soshsc]\r\n \r\n \r\n \r\n <\/div>\r\n \r\n<\/div>","protected":false},"excerpt":{"rendered":"

Myocardial bridging (MB) is a congenital coronary anomaly that is often regarded as a benign condition but may lead to adverse clinical outcomes. 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