{"id":5646,"date":"2026-07-31T11:24:15","date_gmt":"2026-07-31T09:24:15","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=5646"},"modified":"2026-10-12T13:35:04","modified_gmt":"2026-10-12T11:35:04","slug":"cvja-2026-017","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2026-017\/","title":{"rendered":"Association and causality between triglycerides and hypertension: evidence from NHANES 2007\u20132018 and two-sample Mendelian randomisation analysis"},"content":{"rendered":"    <div id=\"article\">                                                                                                                        \r\n        <div id=\"title-container\">                                                                                                    \r\n        <div id=\"authors-title\">                                                                                                            \r\n        <!--Aurthors under Title-->                                                                                                            \r\n            \r\nShan Liang, Xueqin Pan, Xiaofeng Fan, Lin Gong\r\n<\/div>        \r\n<\/div>                                                                                                                            \r\n            <div id=\"copyright\">\r\n        <strong>Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n        of Cardiovascular Journal of Africa.<\/div>\r\n    <div style=\"clear: both;\"><\/div>                                                                                                                                \r\n        <div id=\"article-abstract\">                                                                                                            \r\n            <div id=\"abstract-title\">                                                                                                        \r\n                    Abstract                                                                                                                \r\n                <\/div>                                                                                                                        \r\n                                                                                                                                \r\n            <div id=\"abstract-content\">                                                                                                        \r\n            <!--Content of Abstract Article-->                                                                                                \r\n            <!--<strong>\"Abstract titles\":<\/strong>-->                                                                                        \r\n            <!--<br\/> at the end of each section!!-->                                                                                        \r\n                                                                                                                                                    \r\n\r\n        <strong>Background:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\nHypertension is a major global health issue, and elevated triglyceride levels may be an independent risk factor. However, existing studies are limited, and the association remains unclear across diverse populations. This study uses the National Health and Nutrition Examination Survey (NHANES) data to investigate this association, supporting hypertension prevention and management strategies.\r\n<br \/>    \r\n\r\n        <strong>Methods:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\nData from NHANES (2007\u20132018) for adults aged 20 and older were analysed using a weighted multivariable logistic regression to assess the association between triglyceride levels and prevalence of hypertension. Adjusted odds ratios (OR) with 95% confidence intervals (CIs) were calculated. Restricted cubic splines (RCS) explored the nonlinear association, and subgroup analyses assessed variable impacts on this association. A two-sample Mendelian randomisation (TSMR) analysis based on genome-wide association study (GWAS) summary data was also conducted to investigate the potential causal relationship between triglyceride levels and hypertension.\r\n<br \/>\r\n                \r\n                <strong>Results:<\/strong>                                                                                                    \r\nA total of 14,567 participants were included in this study, among whom 6,428 were diagnosed with hypertension. After full adjustment for all covariates, a significant positive association was observed between triglyceride levels and the prevalence of hypertension (OR: 1.002, 95% CI: 1.001\u20131.003; P < 0.001). RCS regression analysis further demonstrated a significant nonlinear positive association between triglyceride levels and the prevalence of hypertension (P for non-linearity < 0.001; P for overall < 0.001). Subgroup analysis indicated a significant interaction effect by race (P for interaction < 0.001). Mendelian randomisation (MR) analysis also supported a causal effect of elevated triglyceride levels on increased hypertension risk, with no significant pleiotropy or heterogeneity observed.\r\n<br \/>\r\n                                                                                                                                                                                                                                                                        \r\n                                                                                                                                                \r\n        <strong>Conclusion:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\nThe findings of this study suggest that elevated triglyceride levels are significantly associated with increased prevalence of hypertension, highlighting the potential importance of lipid management in hypertension prevention.\r\n<br \/>    \r\n                                                                                                        \r\n\r\n                                                                                                                                                \r\n            <\/div>                                                                                                                            \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                        \r\n                                                                                                                                                \r\n        <div id=\"keywords\">                                                                                                                    \r\n                                                                                                                                            \r\n            <strong>Keywords:<\/strong>                                                                                                        \r\n                                                                                                                                            \r\n            <strong>hypertension, triglycerides, lipid management, NHANES, Mendelian randomisation<\/strong>                                                                                                                                                                                                                    \r\n                                                                                                                                                \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                                \r\n    <div id=\"publish-info\">                                                                                                                    \r\n                                                                                                                                \r\n    <strong>Submitted:<\/strong> January 27, 2025; <!--Month day, year; -->    \r\n    <strong>Accepted:<\/strong> March 10, 2026; <!--Month day, year; -->                                                                            \r\n    <strong>Published:<\/strong> July 31, 2026<!--Month day, year; -->                                                                                                                            <br \/>                                                            \r\n        <em>Cardiovasc J Afr 2025; <b>37<\/b>: 308-318<!--pg no. till pg no. \"eg. 4-7\"--><\/em>\r\n        <br \/><strong>Volume 37, Issue 3<\/strong> <br \/>                                                                            \r\n        <\/div>                                                                                                                            \r\n                                                                                                                                        \r\n    <div id=\"DOI\">                                                                                                                    \r\n            DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2026-017<!--DOI number-->                                                                \r\n        <\/div>                                                                                                                            \r\n                \r\n                <div id=\"author-affiliation\">                                                                                                \r\n\r\n\r\n<strong>Department of Cardiology, Suining Municipal Hospital of Traditional Chinese Medicine, Suining, 629000, Sichuan, P.R. China\r\n\r\n<\/strong>    <br \/>                                                                            \r\nShan Liang<br \/> \r\nXueqin Pan\r\n<br \/><br \/>   \r\n\r\n<strong>Department of Cardiology, Zigong Fourth People's Hospital, Zigong, 643000, Sichuan, P.R. China\r\n\r\n<\/strong>    <br \/>                                                                            \r\nXiaofeng Fan<br \/>\r\nLin Gong\r\n<br \/><br \/>   \r\n  \r\n\r\n                [soshsc hide=\"logged\"]\r\n                <strong>You need to be <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/member-login\/\" target=\"_blank\" rel=\"noopener\">logged in to view and download<\/a> the full text PDF version. <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/register\/\" target=\"_blank\" rel=\"noopener\">Register for a free account?<\/a><\/strong> <br \/><br \/>[\/soshsc]\r\n                \r\n                \r\n                \r\n                <\/div>\r\n    \r\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Hypertension is a major global health issue, and elevated triglyceride levels may be an independent risk factor. However, existing studies are limited, and the association remains unclear across diverse populations. This study uses the National Health and Nutrition Examination Survey (NHANES) data to investigate this association, supporting hypertension prevention and management strategies.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[44,111],"tags":[],"class_list":["post-5646","post","type-post","status-publish","format-standard","hentry","category-cardiovascular-topics","category-volume-37-issue-3"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Association and causality between triglycerides and hypertension: evidence from NHANES 2007\u20132018 and two-sample Mendelian randomisation analysis - Cardiovascular Journal of Africa<\/title>\n<meta name=\"description\" content=\"Hypertension is a major global health issue, and elevated triglyceride levels may be an independent risk factor. However, existing studies are limited, and the association remains unclear across diverse populations. This study uses the National Health and Nutrition Examination Survey (NHANES) data to investigate this association, supporting hypertension prevention and management strategies.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cvja.co.za\/journal\/cvja-2026-017\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Association and causality between triglycerides and hypertension: evidence from NHANES 2007\u20132018 and two-sample Mendelian randomisation analysis - Cardiovascular Journal of Africa\" \/>\n<meta property=\"og:description\" content=\"Hypertension is a major global health issue, and elevated triglyceride levels may be an independent risk factor. 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