{"id":5675,"date":"2026-08-21T08:17:22","date_gmt":"2026-08-21T06:17:22","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=5675"},"modified":"2026-08-21T08:19:34","modified_gmt":"2026-08-21T06:19:34","slug":"cvja-2026-034","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2026-034\/","title":{"rendered":"Prognostic value of preoperative inflammatory and renal markers (SII, NLR, creatinine) on postoperative hospital stay and clinical outcomes in patients undergoing isolated coronary artery bypass graft surgery: a comprehensive analysis"},"content":{"rendered":"    <div id=\"article\">                                                                                                                        \r\n        <div id=\"title-container\">                                                                                                    \r\n        <div id=\"authors-title\">                                                                                                            \r\n        <!--Aurthors under Title-->                                                                                                            \r\n            \r\nUmut Serhat Sanr\u0131, Mehmet Aslan\r\n<\/div>        \r\n<\/div>                                                                                                                            \r\n            <div id=\"copyright\">\r\n        <strong>Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n        of Cardiovascular Journal of Africa.<\/div>\r\n    <div style=\"clear: both;\"><\/div>                                                                                                                                \r\n        <div id=\"article-abstract\">                                                                                                            \r\n            <div id=\"abstract-title\">                                                                                                        \r\n                    Abstract                                                                                                                \r\n                <\/div>                                                                                                                        \r\n                                                                                                                                \r\n            <div id=\"abstract-content\">                                                                                                        \r\n            <!--Content of Abstract Article-->                                                                                                \r\n            <!--<strong>\"Abstract titles\":<\/strong>-->                                                                                        \r\n            <!--<br\/> at the end of each section!!-->                                                                                        \r\n                                                                                                                                                    \r\n\r\n        <strong>Aim:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\nCoronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) induces a systemic inflammatory response, often leading to delayed recovery. This study investigated the predictive value of preoperative inflammatory markers (neutrophil-to-lymphocyte ratio [NLR], systemic immune-inflammation index [SII]) and serum creatinine on the length of hospital stay (LOS) following isolated CABG.\r\n<br \/>    \r\n\r\n        <strong>Methods:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\nA single-centre, retrospective cohort study was conducted on 120 patients undergoing elective isolated CABG between January 2023 and December 2025. Patients were categorised by LOS: Group 1 (\u2264 7 days, n = 88) and Group 2 (> 7 days, n = 32). Preoperative demographic, intraoperative, and laboratory data were compared. Receiver operating characteristic (ROC) and multivariate logistic regression analyses \u2013 adjusted for clinical confounders including CPB time, cross-clamp time, diabetes mellitus (DM), hypertension (HT), and number of grafts \u2013 were performed to identify predictors of prolonged stay.\r\n<br \/>\r\n                \r\n                <strong>Results:<\/strong>                                                                                                    \r\nGroup 2 patients were significantly older and had higher rates of male sex, DM, and HT. Operative times were also significantly longer in Group 2. Preoperative serum creatinine (1.28 \u00b1 0.26 vs. 0.98 \u00b1 0.19 mg\/dL), NLR (3.77 \u00b1 1.39 vs. 2.92 \u00b1 0.96), and SII (911 \u00b1 410 vs. 738 \u00b1 306) were significantly elevated in the prolonged stay group (all p < 0.05). ROC analysis revealed creatinine as the strongest predictor (AUC: 0.826, cut-off > 1.1 mg\/dL), followed by NLR (AUC: 0.749). In the expanded multivariate analysis adjusting for operative and clinical variables, advanced age (p < 0.001) and elevated creatinine levels (p = 0.042) remained strong independent risk factors for prolonged LOS, whereas NLR and SII did not retain independent statistical significance.\r\n<br \/>\r\n                                                                                                                                                                                                                                                                        \r\n                                                                                                                                                \r\n        <strong>Conclusion:<\/strong>                                                                                                    \r\n                                                                                                                                                    \r\nPreoperative serum creatinine and advanced age are strong, independent predictors of prolonged hospital stay after isolated CABG. While NLR and SII are associated with longer stays, they serve better as supportive prognostic indicators in routine preoperative risk stratification.\r\n<br \/>    \r\n                                                                                                        \r\n\r\n                                                                                                                                                \r\n            <\/div>                                                                                                                            \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                        \r\n                                                                                                                                                \r\n        <div id=\"keywords\">                                                                                                                    \r\n                                                                                                                                            \r\n            <strong>Keywords:<\/strong>                                                                                                        \r\n                                                                                                                                            \r\n            <strong>coronary artery bypass grafting, systemic inflammatory response syndrome, length of stay, creatinine, biomarkers<\/strong>                                                                                                                                                                                                                    \r\n                                                                                                                                                \r\n        <\/div>                                                                                                                                    \r\n                                                                                                                                                \r\n    <div id=\"publish-info\">                                                                                                                    \r\n                                                                                                                                \r\n    <strong>Submitted:<\/strong> March 10, 2026; <!--Month day, year; -->    \r\n    <strong>Accepted:<\/strong> May 26, 2026; <!--Month day, year; -->                                                                            \r\n    <strong>Published:<\/strong> August 21, 2026<!--Month day, year; -->                                                                                                                            <br \/>                                                            \r\n        <em>Cardiovasc J Afr 2025; <b>37<\/b>: 339-344<!--pg no. till pg no. \"eg. 4-7\"--><\/em>\r\n        <br \/><strong>Volume 37, Issue 3<\/strong> <br \/>                                                                            \r\n        <\/div>                                                                                                                            \r\n                                                                                                                                        \r\n    <div id=\"DOI\">                                                                                                                    \r\n            DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2026-034<!--DOI number-->                                                                \r\n        <\/div>                                                                                                                            \r\n                \r\n                <div id=\"author-affiliation\">                                                                                                \r\n\r\n\r\n<strong>Department of Cardiovascular Surgery, Faculty of Medicine, Alanya Alaaddin Keykubat University, Antalya, T\u00fcrkiye\r\n\r\n<\/strong>    <br \/>                                                                            \r\nUmut Serhat Sanr\u0131\r\n<br \/><br \/>   \r\n\r\n<strong>Department of Cardiovascular Surgery, Alanya Education and Research Hospital, Antalya, T\u00fcrkiye\r\n\r\n<\/strong>    <br \/>                                                                            \r\nMehmet Aslan\r\n<br \/><br \/>   \r\n  \r\n\r\n                [soshsc hide=\"logged\"]\r\n                <strong>You need to be <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/member-login\/\" target=\"_blank\" rel=\"noopener\">logged in to view and download<\/a> the full text PDF version. <a style=\"color: #c80c44;\" href=\"https:\/\/cvja.co.za\/journal\/register\/\" target=\"_blank\" rel=\"noopener\">Register for a free account?<\/a><\/strong> <br \/><br \/>[\/soshsc]\r\n                \r\n                \r\n                \r\n                <\/div>\r\n    \r\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) induces a systemic inflammatory response, often leading to delayed recovery. This study investigated the predictive value of preoperative inflammatory markers (neutrophil-to-lymphocyte ratio [NLR], systemic immune-inflammation index [SII]) and serum creatinine on the length of hospital stay (LOS) following isolated CABG.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[44,111],"tags":[],"class_list":["post-5675","post","type-post","status-publish","format-standard","hentry","category-cardiovascular-topics","category-volume-37-issue-3"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Prognostic value of preoperative inflammatory and renal markers (SII, NLR, creatinine) on postoperative hospital stay and clinical outcomes in patients undergoing isolated coronary artery bypass graft surgery: a comprehensive analysis - Cardiovascular Journal of Africa<\/title>\n<meta name=\"description\" content=\"Coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) induces a systemic inflammatory response, often leading to delayed recovery. This study investigated the predictive value of preoperative inflammatory markers (neutrophil-to-lymphocyte ratio [NLR], systemic immune-inflammation index [SII]) and serum creatinine on the length of hospital stay (LOS) following isolated CABG.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cvja.co.za\/journal\/cvja-2026-034\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Prognostic value of preoperative inflammatory and renal markers (SII, NLR, creatinine) on postoperative hospital stay and clinical outcomes in patients undergoing isolated coronary artery bypass graft surgery: a comprehensive analysis - Cardiovascular Journal of Africa\" \/>\n<meta property=\"og:description\" content=\"Coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) induces a systemic inflammatory response, often leading to delayed recovery. This study investigated the predictive value of preoperative inflammatory markers (neutrophil-to-lymphocyte ratio [NLR], systemic immune-inflammation index [SII]) and serum creatinine on the length of hospital stay (LOS) following isolated CABG.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cvja.co.za\/journal\/cvja-2026-034\/\" \/>\n<meta property=\"og:site_name\" content=\"Cardiovascular Journal of Africa\" \/>\n<meta property=\"article:published_time\" content=\"2026-08-21T06:17:22+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-08-21T06:19:34+00:00\" \/>\n<meta name=\"author\" content=\"Jaco Moolman\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jaco Moolman\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cvja.co.za\/journal\/cvja-2026-034\/\",\"url\":\"https:\/\/cvja.co.za\/journal\/cvja-2026-034\/\",\"name\":\"Prognostic value of preoperative inflammatory and renal markers (SII, NLR, creatinine) on postoperative hospital stay and clinical outcomes in patients undergoing isolated coronary artery bypass graft surgery: a comprehensive analysis - Cardiovascular Journal of Africa\",\"isPartOf\":{\"@id\":\"https:\/\/cvja.co.za\/journal\/#website\"},\"datePublished\":\"2026-08-21T06:17:22+00:00\",\"dateModified\":\"2026-08-21T06:19:34+00:00\",\"author\":{\"@id\":\"https:\/\/cvja.co.za\/journal\/#\/schema\/person\/6bf8a30a039e93fd8112db707affb920\"},\"description\":\"Coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) induces a systemic inflammatory response, often leading to delayed recovery. This study investigated the predictive value of preoperative inflammatory markers (neutrophil-to-lymphocyte ratio [NLR], systemic immune-inflammation index [SII]) and serum creatinine on the length of hospital stay (LOS) following isolated CABG.\",\"breadcrumb\":{\"@id\":\"https:\/\/cvja.co.za\/journal\/cvja-2026-034\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/cvja.co.za\/journal\/cvja-2026-034\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/cvja.co.za\/journal\/cvja-2026-034\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/cvja.co.za\/journal\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Prognostic value of preoperative inflammatory and renal markers (SII, NLR, creatinine) on postoperative hospital stay and clinical outcomes in patients undergoing isolated coronary artery bypass graft surgery: a comprehensive analysis\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/cvja.co.za\/journal\/#website\",\"url\":\"https:\/\/cvja.co.za\/journal\/\",\"name\":\"Cardiovascular Journal of Africa\",\"description\":\"The Cardiovascular Journal of Africa is a peer-reviewed medical journal publishing leading research in cardiovascular health across Africa since 1990\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/cvja.co.za\/journal\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/cvja.co.za\/journal\/#\/schema\/person\/6bf8a30a039e93fd8112db707affb920\",\"name\":\"Jaco Moolman\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/cvja.co.za\/journal\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/454c6719ed785bfd40e036ca3c3ac3347c56b4a99902df8beb62d882b1e6967f?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/454c6719ed785bfd40e036ca3c3ac3347c56b4a99902df8beb62d882b1e6967f?s=96&d=mm&r=g\",\"caption\":\"Jaco Moolman\"},\"url\":\"https:\/\/cvja.co.za\/journal\/author\/jacodesignconnection-co-za\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Prognostic value of preoperative inflammatory and renal markers (SII, NLR, creatinine) on postoperative hospital stay and clinical outcomes in patients undergoing isolated coronary artery bypass graft surgery: a comprehensive analysis - Cardiovascular Journal of Africa","description":"Coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) induces a systemic inflammatory response, often leading to delayed recovery. This study investigated the predictive value of preoperative inflammatory markers (neutrophil-to-lymphocyte ratio [NLR], systemic immune-inflammation index [SII]) and serum creatinine on the length of hospital stay (LOS) following isolated CABG.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/cvja.co.za\/journal\/cvja-2026-034\/","og_locale":"en_US","og_type":"article","og_title":"Prognostic value of preoperative inflammatory and renal markers (SII, NLR, creatinine) on postoperative hospital stay and clinical outcomes in patients undergoing isolated coronary artery bypass graft surgery: a comprehensive analysis - Cardiovascular Journal of Africa","og_description":"Coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) induces a systemic inflammatory response, often leading to delayed recovery. This study investigated the predictive value of preoperative inflammatory markers (neutrophil-to-lymphocyte ratio [NLR], systemic immune-inflammation index [SII]) and serum creatinine on the length of hospital stay (LOS) following isolated CABG.","og_url":"https:\/\/cvja.co.za\/journal\/cvja-2026-034\/","og_site_name":"Cardiovascular Journal of Africa","article_published_time":"2026-08-21T06:17:22+00:00","article_modified_time":"2026-08-21T06:19:34+00:00","author":"Jaco Moolman","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jaco Moolman","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/cvja.co.za\/journal\/cvja-2026-034\/","url":"https:\/\/cvja.co.za\/journal\/cvja-2026-034\/","name":"Prognostic value of preoperative inflammatory and renal markers (SII, NLR, creatinine) on postoperative hospital stay and clinical outcomes in patients undergoing isolated coronary artery bypass graft surgery: a comprehensive analysis - Cardiovascular Journal of Africa","isPartOf":{"@id":"https:\/\/cvja.co.za\/journal\/#website"},"datePublished":"2026-08-21T06:17:22+00:00","dateModified":"2026-08-21T06:19:34+00:00","author":{"@id":"https:\/\/cvja.co.za\/journal\/#\/schema\/person\/6bf8a30a039e93fd8112db707affb920"},"description":"Coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) induces a systemic inflammatory response, often leading to delayed recovery. This study investigated the predictive value of preoperative inflammatory markers (neutrophil-to-lymphocyte ratio [NLR], systemic immune-inflammation index [SII]) and serum creatinine on the length of hospital stay (LOS) following isolated CABG.","breadcrumb":{"@id":"https:\/\/cvja.co.za\/journal\/cvja-2026-034\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/cvja.co.za\/journal\/cvja-2026-034\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/cvja.co.za\/journal\/cvja-2026-034\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/cvja.co.za\/journal\/"},{"@type":"ListItem","position":2,"name":"Prognostic value of preoperative inflammatory and renal markers (SII, NLR, creatinine) on postoperative hospital stay and clinical outcomes in patients undergoing isolated coronary artery bypass graft surgery: a comprehensive analysis"}]},{"@type":"WebSite","@id":"https:\/\/cvja.co.za\/journal\/#website","url":"https:\/\/cvja.co.za\/journal\/","name":"Cardiovascular Journal of Africa","description":"The Cardiovascular Journal of Africa is a peer-reviewed medical journal publishing leading research in cardiovascular health across Africa since 1990","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/cvja.co.za\/journal\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/cvja.co.za\/journal\/#\/schema\/person\/6bf8a30a039e93fd8112db707affb920","name":"Jaco Moolman","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/cvja.co.za\/journal\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/454c6719ed785bfd40e036ca3c3ac3347c56b4a99902df8beb62d882b1e6967f?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/454c6719ed785bfd40e036ca3c3ac3347c56b4a99902df8beb62d882b1e6967f?s=96&d=mm&r=g","caption":"Jaco Moolman"},"url":"https:\/\/cvja.co.za\/journal\/author\/jacodesignconnection-co-za\/"}]}},"_links":{"self":[{"href":"https:\/\/cvja.co.za\/journal\/wp-json\/wp\/v2\/posts\/5675","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cvja.co.za\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cvja.co.za\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cvja.co.za\/journal\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/cvja.co.za\/journal\/wp-json\/wp\/v2\/comments?post=5675"}],"version-history":[{"count":2,"href":"https:\/\/cvja.co.za\/journal\/wp-json\/wp\/v2\/posts\/5675\/revisions"}],"predecessor-version":[{"id":5679,"href":"https:\/\/cvja.co.za\/journal\/wp-json\/wp\/v2\/posts\/5675\/revisions\/5679"}],"wp:attachment":[{"href":"https:\/\/cvja.co.za\/journal\/wp-json\/wp\/v2\/media?parent=5675"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cvja.co.za\/journal\/wp-json\/wp\/v2\/categories?post=5675"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cvja.co.za\/journal\/wp-json\/wp\/v2\/tags?post=5675"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}