{"id":5717,"date":"2026-09-11T08:33:39","date_gmt":"2026-09-11T06:33:39","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=5717"},"modified":"2026-09-11T08:33:39","modified_gmt":"2026-09-11T06:33:39","slug":"cvja-2026-035","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2026-035\/","title":{"rendered":"Admission neutrophil-to-lymphocyte ratio and target-vessel failure after bifurcation percutaneous coronary intervention in acute coronary syndrome"},"content":{"rendered":"
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\r\n \r\n \r\nMehmet Akif Erd\u00f6l, Ay\u015fe \u0130rem Demirtola, \u00c7a\u011fr\u0131 Yayla, Kadriye Gayretli Yayla, Ahmet G\u00f6ktu\u011f Ertem, Adnan Burak Ak\u00e7ay\r\n\r\n<\/div> \r\n<\/div> \r\n
\r\n Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n of Cardiovascular Journal of Africa.<\/div>\r\n
<\/div> \r\n
\r\n
\r\n Abstract \r\n <\/div> \r\n \r\n
\r\n \r\n \r\n \r\n \r\n\r\n Background:<\/strong> \r\n \r\nCoronary bifurcation lesions represent one of the most complex settings in patients with acute coronary syndrome (ACS) and are associated with worse outcomes after percutaneous coronary intervention (PCI). In addition to anatomical complexity, systemic inflammation may influence long-term vessel-related outcomes. The neutrophil-to-lymphocyte ratio (NLR) is a simple marker of inflammatory burden, but its prognostic value in ACS patients undergoing bifurcation PCI remains unclear.\r\n
\r\n\r\n Methods:<\/strong> \r\n \r\nThis retrospective single-centre study included ACS patients treated with bifurcation PCI using a two-stent strategy between 2022 and 2025. Target-vessel failure (TVF) was defined as a composite of cardiac death, target-vessel-related myocardial infarction, and repeat target-vessel revascularisation. Independent predictors of TVF were evaluated using multivariable logistic regression.\r\n
\r\n \r\n \r\n Results:<\/strong> \r\n \r\nA total of 146 patients were included, with a median follow-up of 29 months. TVF occurred in 22 patients (20.8%). Patients with TVF had higher NLR values and higher SYNTAX scores. In multivariable analysis, both NLR and SYNTAX score remained independently associated with TVF.\r\n
\r\n\r\n Conclusion:<\/strong> \r\n \r\nIn ACS patients undergoing bifurcation PCI, increased inflammatory burden reflected by NLR and greater coronary complexity are independently associated with TVF, supporting the use of combined inflammatory and angiographic risk assessment after PCI.\r\n
\r\n\r\n \r\n\r\n \r\n <\/div> \r\n <\/div> \r\n \r\n \r\n
\r\n \r\n Keywords:<\/strong> \r\n \r\n clinical outcomes, coronary bifurcation, inflammation, neutrophil-to-lymphocyte ratio, target-vessel failure<\/strong> \r\n \r\n <\/div> \r\n \r\n
\r\n \r\n Submitted:<\/strong> January 27, 2026; \r\n Accepted:<\/strong> May 28, 2026; \r\n Published:<\/strong> September 11, 2026
\r\n Cardiovasc J Afr 2025; 37<\/b>: 318-324<\/em>\r\n
Volume 37, Issue 3<\/strong>
\r\n <\/div> \r\n \r\n
\r\n DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2026-035 \r\n <\/div> \r\n \r\n
\r\n\r\nCardiology Unit, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkey\r\n\r\n<\/strong>
\r\nMehmet Akif Erd\u00f6l
\r\nAy\u015fe \u0130rem Demirtola
\r\n\u00c7a\u011fr\u0131 Yayla
\r\nAhmet G\u00f6ktu\u011f Ertem
\r\nAdnan Burak Ak\u00e7ay\r\n

\r\n\r\nCardiology Unit, Dr Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital, University of Health Sciences, Ankara, Turkey\r\n\r\n<\/strong>
\r\nKadriye Gayretli Yayla\r\n

\r\n\r\n\r\n [soshsc hide=\"logged\"]\r\n \r\n You need to be logged in to view and download<\/a> the full text PDF version. Register for a free account?<\/a><\/strong>

[\/soshsc]\r\n \r\n \r\n \r\n <\/div>\r\n \r\n<\/div>","protected":false},"excerpt":{"rendered":"

Coronary bifurcation lesions represent one of the most complex settings in patients with acute coronary syndrome (ACS) and are associated with worse outcomes after percutaneous coronary intervention (PCI). In addition to anatomical complexity, systemic inflammation may influence long-term vessel-related outcomes. The neutrophil-to-lymphocyte ratio (NLR) is a simple marker of inflammatory burden, but its prognostic value in ACS patients undergoing bifurcation PCI remains unclear.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[44,111],"tags":[],"class_list":["post-5717","post","type-post","status-publish","format-standard","hentry","category-cardiovascular-topics","category-volume-37-issue-3"],"yoast_head":"\nAdmission neutrophil-to-lymphocyte ratio and target-vessel failure after bifurcation percutaneous coronary intervention in acute coronary syndrome - Cardiovascular Journal of Africa<\/title>\n<meta name=\"description\" content=\"Coronary bifurcation lesions represent one of the most complex settings in patients with acute coronary syndrome (ACS) and are associated with worse outcomes after percutaneous coronary intervention (PCI). 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