{"id":5723,"date":"2026-09-11T08:43:03","date_gmt":"2026-09-11T06:43:03","guid":{"rendered":"https:\/\/cvja.co.za\/journal\/?p=5723"},"modified":"2026-09-11T08:43:03","modified_gmt":"2026-09-11T06:43:03","slug":"cvja-2026-037","status":"publish","type":"post","link":"https:\/\/cvja.co.za\/journal\/cvja-2026-037\/","title":{"rendered":"NT-proBNP in women with gestational hypertension, uncomplicated preeclampsia, normotensive pregnancies, and echocardiographic correlations"},"content":{"rendered":"
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\r\n \r\n \r\nDolina Gencheva, Fedya Nikolov, Ekaterina Uchikova, Blagovesta Pencheva, Rosen Mihaylov\r\n<\/div> \r\n<\/div> \r\n
\r\n Copyright:<\/strong> Clinics Cardive Publishing (Pty) Ltd. publisher\r\n of Cardiovascular Journal of Africa.<\/div>\r\n
<\/div> \r\n
\r\n
\r\n Abstract \r\n <\/div> \r\n \r\n
\r\n \r\n \r\n \r\n \r\n\r\n Objective:<\/strong> \r\n \r\nTo determine and compare serum NT-proBNP levels among women with gestational hypertension (GH), uncomplicated preeclampsia (PE), and normotensive pregnancies, and to assess their associations with maternal clinical characteristics and echocardiographic parameters.\r\n
\r\n\r\n Methods:<\/strong> \r\n \r\nThis prospective, single-centre study analysed 35 women with GH, 36 with uncomplicated PE, and 50 healthy pregnant controls. All participants underwent clinical evaluation, comprehensive two-dimensional echocardiography, and biomarker testing.\r\n
\r\n \r\n \r\n Results:<\/strong> \r\n \r\nNT-proBNP concentrations were significantly lower in the GH group (42.3 \u00b1 52.0 pg\/mL) compared to both normotensive pregnancies (50.1 \u00b1 40.3 pg\/mL; p = 0.04) and uncomplicated PE cases (87.7 \u00b1 75.3 pg\/mL; p = 0.002). No significant difference was observed between uncomplicated PE and controls. ROC curve analysis demonstrated a moderate discriminatory ability of NT-proBNP for GH versus PE (AUC = 0.71); women with levels \u2264 6.25 pg\/mL were 7.9 times more likely to have GH than PE. In normotensive pregnancy, NT-proBNP correlated with parameters of cardiac chamber dilation. In PE, higher NT-proBNP levels were associated with more favourable left ventricular functional indices, whereas fewer correlations were observed in the GH cohort.\r\n
\r\n\r\n Conclusion:<\/strong> \r\n \r\nNT-proBNP levels differ significantly among hypertensive disorders of pregnancy and may reflect distinct pathophysiological mechanisms and cardiovascular adaptation patterns.\r\n
\r\n\r\n \r\n\r\n \r\n <\/div> \r\n <\/div> \r\n \r\n \r\n
\r\n \r\n Keywords:<\/strong> \r\n \r\n gestational hypertension, pregnancy, NT-proBNP, preeclampsia, echocardiography, hypertensive disorders of pregnancy<\/strong> \r\n \r\n <\/div> \r\n \r\n
\r\n \r\n Submitted:<\/strong> January 16, 2026; \r\n Accepted:<\/strong> June 8, 2026; \r\n Published:<\/strong> September 11, 2026
\r\n Cardiovasc J Afr 2025; 37<\/b>: 365-374<\/em>\r\n
Volume 37, Issue 3<\/strong>
\r\n <\/div> \r\n \r\n
\r\n DOI Citation Reference: dx.doi.org\/10.5830\/CVJA-2026-037 \r\n <\/div> \r\n \r\n
\r\n\r\n\r\nSection of Cardiology, First Department of Internal Diseases, Medical University of Plovdiv; Clinic of Cardiology, UMHAT Sveti Georgi, Plovdiv, Bulgaria\r\n\r\n<\/strong>
\r\nDolina Gencheva
\r\nFedya Nikolov\r\n

\r\n\r\nDepartment of Obstetrics and Gynaecology, Medical University of Plovdiv; Clinic of Obstetrics and Gynaecology, UMHAT Sveti Georgi, Plovdiv, Bulgaria\r\n\r\n<\/strong>
\r\nEkaterina Uchikova\r\n\r\n

\r\n\r\nRAMUS Independent Medical Diagnostic Laboratory, Sofia, Bulgaria\r\n\r\n<\/strong>
\r\nBlagovesta Pencheva
\r\nRosen Mihaylov\r\n

\r\n\r\nNational Sports Academy \u201cVasil Levski\u201d, Sofia, Bulgaria\r\n\r\n<\/strong>
\r\nRosen Mihaylov\r\n

\r\n\r\n\r\n [soshsc hide=\"logged\"]\r\n \r\n You need to be logged in to view and download<\/a> the full text PDF version. Register for a free account?<\/a><\/strong>

[\/soshsc]\r\n \r\n \r\n \r\n <\/div>\r\n \r\n<\/div>","protected":false},"excerpt":{"rendered":"

To determine and compare serum NT-proBNP levels among women with gestational hypertension (GH), uncomplicated preeclampsia (PE), and normotensive pregnancies, and to assess their associations with maternal clinical characteristics and echocardiographic parameters.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[44,111],"tags":[],"class_list":["post-5723","post","type-post","status-publish","format-standard","hentry","category-cardiovascular-topics","category-volume-37-issue-3"],"yoast_head":"\nNT-proBNP in women with gestational hypertension, uncomplicated preeclampsia, normotensive pregnancies, and echocardiographic correlations - Cardiovascular Journal of Africa<\/title>\n<meta name=\"description\" content=\"To determine and compare serum NT-proBNP levels among women with gestational hypertension (GH), uncomplicated preeclampsia (PE), and normotensive pregnancies, and to assess their associations with maternal clinical characteristics and echocardiographic parameters.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cvja.co.za\/journal\/cvja-2026-037\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NT-proBNP in women with gestational hypertension, uncomplicated preeclampsia, normotensive pregnancies, and echocardiographic correlations - 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