CARDIOVASCULAR JOURNAL OF AFRICA • PAFCIC 2021 Abstracts December 2021 53 AFRICA MODERATED POSTER SESSION 4 Submission ID: 1158 RELATIONSHIP OF RS1800796 -G572C VARIANT WITH SERUM INTERLEUKIN-6 LEVELS, AND IN-STENT RESTENOSIS IN TUNISIAN PATIENTS AFTER PERCUTANEOUS CORONARY INTERVENTION Bouzidi Nadia, Habib Gamra, Salima Ferchichi Clinical and molecular biology unit (UR 17ES29) - University of Monastir - Faculty of Pharmacy – Tunisia Background: It has been shown that Interleukin-6 (IL-6) levels were involved in the development of coronary artery disease (CAD). In-stent restenosis (ISR) is a primary complication of percutaneous coronary intervention (PCI) including biological and mechanical factors such as local inflammatory response. This study aimed to investigate whether the single nucleotide polymorphism -G572C (rs1800796) of IL-6 gene was associated with the risk of ISR and circulating IL-6 levels in Tunisian population. Methods: This study recruited 67 patients who received stent implantation and 39 were diagnosedwith ISRafter PCI during the one-year follow-up period. Based on coronary angiography, the cases were divided into ISR and non-ISR groups. ISR was defined as a reduction in lumen diameter by over 50% after PCI. The IL-6 G572C (rs1800796) polymorphism was genotyped, and the IL-6 concentrations were measured. Results: Serum IL-6 levels were high in both patients groups (No ISR: 7.8 (2.1-139.6) pg/mL and ISR: 7.9(3.9-1957.0) pg/mL) and difference was not statistically significant, P > 0.05). IL-6 G572C polymorphism frequencies of the MTHFR gene patients were not associated with ISR (No ISR: GG: 53.6, GC: 25.0, CC: 21.4% vs. ISR: GG: 17.9, GC: 23.0, CC: 9.0 %; p = 0.199). The distribution of IL-6 levels according to G572C genotypes didn’t show significant association p > 0.05. IL-6 (AUC 0.52 p = 0.7) failed to provide significant results in receiver-operating characteristic analysis. Conclusions: Circulating levels of IL-6 were not influenced by G572C polymorphism and highest levels were not associated with ISR one year after PCI. Despite its involvement in the pathogenesis of atherosclerotic disease, Il-6 levels and its G572C variant have no predictive value for identifying patients with recurrent restenosis. Submission ID: 1164 SERUM AMYLOIDE A AND HIGH SENSITIVITY C-REACTIVE PROTEIN IN ACUTE PHASE OF ACUTE CORONARY SYNDROME WITH ST-SEGMENT ELEVATION Bouzidi Nadia, Gamra Habib, Ferchichi Salima Clinical and molecular biology unit (UR 17ES29) - University of Monastir - Faculty of Pharmacy – Tunisia Background: Atherosclerosis is widely accepted as a chronic inflammatory disease initiated by different vascular and extravascular sources. An unstable, and subsequently ruptured, atherosclerotic coronary plaque with superimposed thrombosis constitutes the most common, general, and pathological background of the acute coronary syndrome (ACS). SAA and CRPus, markers of acute phase reactants appear as early markers of atherogenesis. Our stydy aim to determine the interest of these markers in ACS with ST-segment elevation ACS(ST+). Methods: The present study consisted of 31 patients (19 women and 12 men, mean age 63±12 years), who were admitted to cardiology departement CHU Farhat Hached Sousse for ACS with ST-segment elevation. The control group consisted of 55 healthy subjects (mean age 40 ± 10 years). HsCRP concentrations were measured by Immunoturbidimetry using a COBAS INTEGRA 400 analyser (Roche). Serum amyloid A(SAA) level was determined by nephelometric method using a BN ProsPec (Dade Behring Diagnostic, Marburg, Germany). Database management and statistical analyses were carried out using SPSS (Statistical Package for the Sociological Sciences), version 17.0. Results: In the SCA, our results showed: a statistically significant increase hsCRP and SAA in patients with ACS(ST+) compared with the control group (hsCRP: 9,79±6,85 vs 1,3±0,8mg/L (p=0,001); (SAA: 6,94±2,87 vs 3,06±2,16mg/L (p=0,001). Both inflammatory markers exhibit a statistically significant correlation (p=0.01) after thrombolysis. Conclusion: In post infarction, CRPus and SAA increase, reflecting and participating perhaps in the inflammation that accompanies tissue necrosis. SAA together with hs-CRP have been associated with a major number of complicated lesions in patients with ACS. Submission ID: 1224 RISK OF TOBOCCO IN THE DEVELOPMENT OF ACUTE CORONARY SYNDROME OUSSEMA ACHECHE, SAFA HADRICH, AMANI BOUZIDI, MEHDI SLIM, RAHMA JABALLAH, HOUDA BEN SALAH, LOTFI BOUKADIDA, ASMA ZORGATI, RIADH BOUKEF Emergency department Sahloul Sousse, Tunisia Introduction: STEMI is most frequent with younger patients and smoking is the major cause of the disease occurrence Purpose: The aim of this study is to accuse tobacco as a major and independent risk factor of the occurrence of SCA ST + in a younger population. Materials and methods: Retrospective study is based on all the patients consulted for chest pain in the emergency room of sahloul and who are diagnosed with STEMI according to a pathological ECG which shows a persistent segment ST elevation. The patients are divided into two groups: smokers and non-smokers groups. All the demographic, clinical and biologica l characteristics of patients are noted. Statistical analyzes are carried out by using SPSS18. Results: 638 patients included in a study of which 322 were smokers and 316 were non-smokers. Comparing the two groups according to age, the smokers are younger than the non-smokers with a significant difference (p <0.001). A significant difference among genderbased groups. The difference is also notable in the become STEMI patients admitted to the ER within a month: in fact all smoking patients resorted to use angioplasty after a pathological coronary angiography; Among them, 5.6% of smokers group manifested a MACE event in one month versus 2.1% of non-smokers with a significant difference (p = 0.004). however, the re-consultation rate is in non-significant between the two groups. Conclusion: Smoking represents an essential prevention challenge for all players in public health, in particular emergency room physicians and cardiologists. Better control of this factor, in primary prevention, would avoid cardiovascular accidents at youngest possible age, and, in secondary prevention, would reduce the number of cardiovascular accidents by the half within patients who stop smoking.
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