Cardiovascular Journal of Africa: Vol 32 No 6 (NOVEMBER/DECEMBER 2021)

CARDIOVASCULAR JOURNAL OF AFRICA • Volume 32, No 6, November/December 2021 AFRICA 299 D-dimer. 32 A case of probable pulmonary embolism was seen in a patient in this preliminary report. In addition to SARS- Cov-2 infection, the patient was also at risk of pregnancy- associated venous thromboembolism. Delivery by caesarean section increased her risk for pulmonary embolism. There is a paucity of reports relating to the multi-systemic impact of COVID-19 in Africa. A Dar es Salaam case series reported association with stroke in three cases. 33 Among the first 32 COVID-19 patients admitted in Nigeria, 9% had breathlessness. 34 There is no information provided on the evaluation of the breathlessness beyond SARS-Cov-2 infection. In a report of 10 patients with severe COVID-19, admitted in an intensive care unit in Tunisia, four had neurological complications. 35 There are also no details provided on cardiovascular evaluation of the patients. Conclusion The commonest manifestation of COVID-19 disease in this preliminary report was heart failure. COVID-19 is a multi- systemic disease with cardiac manifestation being one of its commonest complications. The choice of out-of-hospital isolation-centre treatment, which is adopted in Nigeria, is not an ideal setting for the management of a multi-systemic disease that requires a multidisciplinary approach in its management. This unfortunately also impacted negatively on this study, as well as local understanding of the disease condition. In view of the protracted nature of the pandemic, a change of policy will be necessary. References 1. Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al . A pneu- monia outbreak associated with a new coronavirus of probable bat origin. Nature 2020; 579 : 270–273. 2. Roujian L, Xiang Z, Juan L, Peihua N, Bo Y, Honglong W, et al . Genomic characterisation and epidemiology of 2019 novel coronavi- rus: implications for virus origins and receptor binding. Lancet 2020; 395 (10224): 565–574. 3. Sohrabi C, Alsafi Z, O’Neill N, Khan M, Kerwan A, Al-Jabir A, et al . World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). Int J Surg 2020; 76 : 71–76. 4. Cui J, Li F, Shi ZL. Origin and evolution of pathogenic coronaviruses. Nature Rev Microbiol 2018; 17 (2019): 181–192. 5. Du L, He Y, Zhou Y, Liu S, Zheng BJ, Jiang S. The spike protein of SARS-CoV – A target for vaccine and therapeutic development. Nature Rev Microbiol 2009; 7 : 226–236. 6. Shang J, Wan Y, Luo C, Ye G, Geng Q, Auerbach A, et al . Cell entry mechanisms of SARS-CoV-2. Proc Natl Acad Sci USA 2020; 117 (21): 11727–11734. 7. Lan J, Ge J, Yu J, Shan S, Zhou H, Fan S, et al . Structure of the SARS- CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature 2020; 581 : 215–220. 8. Tikellis C, Thomas MC. Angiotensin-converting enzyme 2 (ACE2) is a key modulator of the renin angiotensin system in health and disease. Int J Peptides 2012; 2012 (256294). 9. Tikellis C, Bernardi S, Burns WC. Angiotensin-converting enzyme 2 is a key modulator of the renin-angiotensin system in cardiovascular and renal disease. Curr Opin Nephrol Hypertens 2011; 20 (1): 62–68. 10. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al . Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395 (10233): 497–506. 11. Clerkin KJ, Fried JA, Raikhelkar J, Sayer G, Griffin JM, Masoumi A, et al. COVID-19 and cardiovascular disease. Circulation 2020; 141 (20): 1648–1655. 12. Li B, Yang J, Zhao F, Zhi L, Wang X, Liu L, et al . Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China. Clin Res Cardiol 2020; 109 (5): 531–538. 13. Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al . Clinical character- istics of coronavirus disease 2019 in China. N Engl J Med 2020; 382 : 1708–1720. 14. García LF. Immune response, inflammation, and the clinical spectrum of COVID-19. Frontiers Immunol 2020; 11 : 1441. 15. Stefanini GG, Montorfano M, Trabattoni D, Andreini D, Ferrante G, Ancona M, et al . ST-elevation myocardial infarction in patients with COVID-19: clinical and angiographic outcomes. Circulation 2020; 141 : 2113–2116. 16. Deng Q, Hu B, Zhang Y, Wang H, Zhou X, Hu W, et al . Suspected myocardial injury in patients with COVID-19: Evidence from front-line clinical observation in Wuhan, China. Int J Cardiol 2020; 311 : 116–121. 17. Aghagoli G, Gallo MB, Soliman LB, Sellke FW. Cardiac involvement in COVID-19 patients: Risk factors, predictors, and complications: a review. J Cardiac Surg 2020; 35 (6): 1302–1305. 18. Hulot JS. COVID-19 in patients with cardiovascular diseases. Arch Cardiovasc Dis 2020; 113 (4): 225–226. 19. Centers for Disease Control COVID-19 Response Team. Severe outcomes among patients with coronavirus disease 2019 (COVID-19) – United States, February 12 – March 16, 2020. MMWR Morb Mortal Wkly Rep 2020; 69 (12): 343–346. 20. Fried JA, Ramasubbu K, Bhatt R, Topkara VK, Clerkin KJ, Horn E, et al . The variety of cardiovascular presentations of COVID-19. Circulation 2020; 141 : 1930–1936. 21. Newton-Cheh C, Zlotoff DA, Hung J, Rupasov A, Crowley JC, Funamoto M. Case 24-2020: a 44-year-old woman with chest pain, dyspnea, and shock. N Engl J Med 2020; 383 : 475–484. 22. Tavazzi G, Pellegrini C, Maurelli M, Belliato M, Sciutti F, Bottazzi A, et al . Myocardial localization of coronavirus in COVID-19 cardiogenic shock. Eur J Heart Fail 2020; 22 (5): 911–915. 23. Sala S, Peretto G, Gramegna M, Palmisano A, Villatore A, Vignale D, et al . Acute myocarditis presenting as a reverse Tako-Tsubo syndrome in a patient with SARS-CoV-2 respiratory infection. Eur Heart J 2020; 41(19): 1861–1862. 24. Caforio ALP, Pankuweit S, Arbustini E, Basso C, Gimeno-Blanes J, Felix SB, et al . Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: A position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J 2013; 34 (33): 2636–2648. 25. Chen T, Wu D, Chen H, Yan W, Yang D, Chen G, et al . Clinical characteristics of 113 deceased patients with coronavirus disease 2019: Retrospective study. Br Med J 2020; 368 : 1295. 26. Freaney PM, Shah SJ, Khan SS. COVID-19 and heart failure with preserved ejection fraction. J Am Med Assoc 2020; 324 (15): 1499–1500. 27. De Boer RA, Nayor M, DeFilippi CR, Enserro D, Bhambhani V, Kizer JR, et al . Association of cardiovascular biomarkers with incident heart failure with preserved and reduced ejection fraction. J Am Med Assoc Cardiol 2018; 3(3): 215–224. 28. Jabri A, Kalra A, Kumar A, Alameh A, Adroja S, Bashir H, et al . Incidence of stress cardiomyopathy during the coronavirus disease 2019 pandemic. J Am Med Assoc Netw Open 2020; 3 (7): e2014780. 29. Xie Y, Wang X, Yang P, Zhang S. COVID-19 complicated by acute pulmonary embolism. Radiol Cardiothorac Imaging 2020; 2 (2): e200067.

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