Cardiovascular Journal of Africa: Vol 32 No 6 (NOVEMBER/DECEMBER 2021)
CARDIOVASCULAR JOURNAL OF AFRICA • Volume 32, No 6, November/December 2021 AFRICA 313 however, apparent and echoed in other studies. This rapidly growing field with the novel use of biomarkers and ultrasound allows for further exploration. Pre-operative echocardiography information, together with data on the use of inotropes, diuretics, fluids and blood products intra-operatively, leaves the researchers with an opportunity to investigate such variables in a future prospective study. Conclusion Numerous modifiable factors including pre-operative renal dysfunction were found to be associated with the development of CSA-AKI and mortality. Identification of patients at risk of CSA-AKI, relying on serial SCr and/or urine output measurements may not be time sensitive and may delay timeous interventions. The use of novel biomarkers and renal vascular ultrasound promises the possibility of early diagnosis of renal injury. Kidney injury should be considered an important factor in post-operative outcomes in cardiac surgery. Those at risk of kidney injury should be identified and risk-modification strategies employed. Renal function is crucial for enhanced recovery after cardiac surgery, as evidenced by studies that show its association with adverse outcomes. We thank Dr Katharina-Maria Vanderdonck for her assistance with data collection. References 1. Bastin AJ, Ostermann M, Slack AJ, Diller GP, Finney SJ, Evans TW. Acute kidney injury after cardiac surgery according to Risk/Injury/ Failure/Loss/End-stage, Acute Kidney Injury Network, and Kidney Disease: Improving Global Outcomes classifications. J Crit Care 2013; 28 : 389–396. 2. Freeland K, Hamidian Jahromi A, Duvall LM, Mancini MC. Post- operative blood transfusion is an independent predictor of acute kidney injury in cardiac surgery patients. J Nephropathol 2015; 4 : 121–126. 3. O’Neal JB, Shaw AD, Billings FT. Acute kidney injury following cardiac surgery: current understanding and future directions. Crit Care 2016; 20 : 187. 4. Machado MN, Nakazone MA, Maia LN. Acute kidney injury based on KDIGO (Kidney Disease Improving Global Outcomes) criteria in patients with elevated baseline serum creatinine undergoing cardiac surgery. Rev Bras Cir Cardiovasc 2014; 29 : 299–307. 5. Fuhrman DY, Kellum JA. Epidemiology and pathophysiology of cardiac surgery-associated acute kidney injury. Curr Opin Anaesthesiol 2017; 30 : 60–65. 6. Adu D, Okyere P, Boima V, Matekole M, Osafo C. Community-acquired acute kidney injury in adults in Africa. Clin Nephrol 2016; 86 : 48–52. 7. Olowu WA, Niang A, Osafo C, Ashuntantang G, Arogundade FA, Porter J, et al. Outcomes of acute kidney injury in children and adults in sub-Saharan Africa: a systematic review. Lancet Glob Health 2016; 4 : e242-250. 8. Bhadade R, De’Souza R, Harde MJ, Mehta KS, Bhargava P. A prospec- tive study of acute kidney injury according to KDIGO definition and its mortality predictors. J Assoc Physicians India 2016; 64 : 22–28. 9. Chakravarthy M. Modifying risks to improve outcome in cardiac surgery: An anesthesiologist’s perspective. Ann Card Anaesth 2017; 20 : 226–233. 10. Rosner MH, Okusa MD. Acute kidney injury associated with cardiac surgery. Clin J Am Soc Nephrol 2006; 1 : 19–32. 11. Boodhwani M, Rubens FD, Wozny D, Nathan HJ. Effects of mild hypo- thermia and rewarming on renal function after coronary artery bypass grafting. Ann Thorac Surg 2009; 87 : 489–495. 12. James M, Bouchard J, Ho J, Klarenbach S, LaFrance JP, Rigatto C, et al . Canadian Society of Nephrology commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury. Am J Kidney Dis 2013; 61 : 673–685. 13. Fiseha T, Mengesha T, Girma R, Kebede E, Gebreweld A. Estimation of renal function in adult outpatients with normal serum creatinine. BMC Res Notes 2019; 12 : 462. 14. Khwaja A. KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract 2012; 120 : 179–184. 15. Gregory AJ, Grant MC, Manning MW, Cheung AT, Ender J, Sander M, et al . Enhanced Recovery After Cardiac Surgery (ERAS Cardiac) recommendations: an important first step-but there is much work to be done. J Cardiothorac Vasc Anesth 2020; 34 : 39–47. 16. Weir MR, Aronson S, Avery EG, Pollack CV, Jr. Acute kidney injury following cardiac surgery: role of peri-operative blood pressure control. Am J Nephrol 2011; 33 : 438–452. 17. Vellinga S, Verbrugghe W, De Paep R, Verpooten GA, Janssen van Doorn K. Identification of modifiable risk factors for acute kidney injury after cardiac surgery. Neth J Med 2012; 70 : 450–454 18. Lassnigg A, Schmidlin D, Mouhieddine M, Bachmann LM, Druml W, Bauer P, et al . Minimal changes of serum creatinine predict prognosis in patients after cardiothoracic surgery: a prospective cohort study. J Am Soc Nephrol 2004; 15 : 1597–1605. 19. Nadim MK, Forni LG, Bihorac A, Hobson C, Koyner JL, Shaw A, et al . Cardiac and vascular surgery-associated acute kidney injury: the 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group. J Am Heart Assoc 2018; 7 . 20. Leballo G, Chakane PM. Cardiac surgery-associated acute kidney injury: pathophysiology and diagnostic modalities and management. Cardiovasc J Afr 2020; 31 : 1–8. 21. Göcze I, Jauch D, Götz M, Kennedy P, Jung B, Zeman F, et al . Biomarker-guided intervention to prevent acute kidney injury after major surgery: the Prospective Randomized BigpAK Study. Ann Surg 2018; 267 : 1013–1020. 22. Beaubien-Souligny W, Benkreira A, Robillard P, Bouabdallaoui N, Chasse M, Desjardins G, et al . Alterations in Portal Vein Flow and Intrarenal Venous Flow Are Associated With Acute Kidney Injury After Cardiac Surgery: A Prospective Observational Cohort Study. J Am Heart Assoc. 2018; 7 : e009961. 23. Pettey G, Motshabi P. Novel modalities for the diagnosis of cardiac surgery associated acute kidney injury: a narrative review of the litera- ture. Sthn Afr J Anaesth Analg 2020; 26 : 65–72. 24. Machado MN, Nakazone MA, Maia LN. Prognostic value of acute kidney injury after cardiac surgery according to kidney disease: improv- ing global outcomes definition and staging (KDIGO) criteria. PLoS One 2014; 9 : e98028. 25. Hu J, Chen R, Liu S, Yu X, Zou J, Ding X. Global incidence and outcomes of adult patients with acute kidney injury after cardiac surgery: a systematic review and meta-analysis. J Cardiothorac Vasc Anesth 2016; 30 : 82–89. 26. Domoto S, Tagusari O, Nakamura Y, Takai H, Seike Y, Ito Y, et al. Pre-operative estimated glomerular filtration rate as a significant predic- tor of long-term outcomes after coronary artery bypass grafting in Japanese patients. Gen Thorac Cardiovasc Surg 2014; 62 : 95–102.
Made with FlippingBook
RkJQdWJsaXNoZXIy NDIzNzc=