AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 18 MODERATED POSTER SESSION Submission ID: 1382 ALTERATIONS IN LEFT VENTRICULAR FUNCTION IN PATIENTS WITH AORTIC STENOSIS AND PRESERVED EJECTION FRACTION: THE VALUE OF GLOBAL LONGITUDINAL STRAIN. EXPERIENCE OF THE CARDIOLOGY DEPARTMENT AT IBN ROCHD HOSPITAL UNIVERSITY IN CASABLANCA. H. BENDAHOU, M. NJIE, K. BADAOUI, S. ABOURADI, Z. SOUKAINA, M. NJIE, M. AMRI, M. TAMIR, M. HABOUB, S. AROUS, G. BENNOUNA, A. DRIGHIL, L. AZZOUZI, R. HABBAL MOROCCO Introduction: Left ventricular longitudinal systolic function as well as longitudinal global strain (GLS) represent sensitive markers of subclinical LV systolic dysfunction. They are often altered in tight calcified aortic stenosis (AS) while the ejection fraction (LVEF) is preserved for a long time. The objective of our study was to assess the degree of early impairment of LGS and LV longitudinal systolic function compared to LVEF, thus their prognostic value in tight AS. Materials: We conducted a prospective study, fromOctober 2017 to June 2022, on patients with valvulopathies, collected from the day hospital, at the cardiology department of the CHU Ibn Rochd in Casablanca. We compared patients with tight BCR (G1) and those with moderately tight BCR (G2) and compared LVEF to SGL and peak S wave at the mitral annulus (S’VG) in the 2 groups. Results: Over the 4 years of study, out of a total of 720 patients with valvular heart disease, 252 had AS, 101 of which were isolated (39.9%). The mean age was 58.6 years (+/-10), with a sex ratio (M/F) of 0.7. The mean LVEF was 56.15% in G1 and 57.2% in G2, the mean SGL was -14.1+/- 3.34% in G1 versus -16.1+/- 4, 01% in the G2. LVS was significantly more altered in G1 (average LVS at 6cm/s versus 13cm/s in G2). SGL was altered while LVEF was still preserved in 68% and 34% respectively in the 2 groups (p=0.82 and 0.02). Submission ID: 1383 GENDER CAN INFLUENCE PARAMETERS AND PROGNOSIS OF MITRAL STENOSIS? EXPERIENCE OF THE CARDIOLOGY DEPARTMENT OF THE IBN ROCHD CASABLANCA HOSPITAL CENTER H. BENDAHOU, S. ZAHRI, M. NJIE, K. BADAOUI, E. TAMIR, M. AMRI, M. HABOUB, S. AROUS, G. BENNOUNA, A. DRIGHIL, L. AZZOUZI, R. HABBAL MOROCCO Introduction: Mitral stenosis (MS) is the most common valvular disease in Morocco, often due to acute articular rheumatism. It affects women more frequently. The aim of our study was to compare the clinical and echocardiographic characteristics qnd prognosis of MS according to gender. Materials and methods: We conducted a prospective study, fromOctober 2017 to June 2022, on patients with valvulopathies, collected from the day hospital, at the cardiology department of the CHU Ibn Rochd in Casablanca. We compared 2 groups: Group I (men), Group II (women). Study analysis was performed using SPSS version 20 software. Results: Over the 4 years of study, out of a total of 720 patients with valve disease, 331 patients had an MS (46%), of which 194 were tight. The average age was 60 years (+/- 10.27), with a sex ratio (M/F) of 0.7. We formed two groups: 96 men 28.9% (group I) and 235 women 71.1% (group II). Comparison of clinical data (history of rheumatic fever, repeated angina, stage of dyspnea, palpitations) revealed no significant difference, however there is a higher incidence of left atrial electrical hypertrophy in group I (p <0.001). Regarding the echocardiographic data, in men, the left atrium was more dilated (p=0.049), the mitral surface was tighter (p=0.024) and the right ventricular dilatation was more frequent (54% vs 28% with p=0.036). There was no significant difference in mean gradient, calcifications and therapeutic indication. Conclusion: Our study suggests that MS in humans is more severe with more impact on the size of the left atrium as well as on that of the right ventricle, without valvular anatomical difference and therefore without influence on the therapeutic indications. Submission ID: 1388 INSIGHTS INTO THE CLINICAL COURSE AND THERAPEUTIC RESPONSE OF ANTHRACYCLINE-INDUCED CARDIOTOXICITY IN BREAST CANCER PATIENTS: CASABLANCA CARDIO-ONCOLOGY UNIT EXPERIENCE AMIRA ABOURICHE, HAJAR BENDAHOU, ANASS MAAROUFI, SOUKAINA ZAHRI, SAMIA EJJEBLI, LEILA AZZOUZI, RACHIDA HABBAL, SOUKAINA LABDELLAOUI, SOUHA SAHRAOUI, NEZHA TAWFIQ MOROCCO Background Anthracycline-induced cardiotoxicity is a rapidly evolving disease that can lead to chronic heart failure. Despite dosing limitations, the prevalence of anthracycline-induced cardiac dysfunction is estimated to be 6% for explicit heart failure and up to 18% for subclinical cardiac dysfunction. The purpose of this study was to determine the clinical significance of anthracycline-induced cardiomyopathy (AC-CMP) and its response to treatment for heart failure (HF). Methods We included 121 patients with a > 10% decrease in left ventricular ejection fraction (LVEF) with a value < 50% due to AC-CMP and Figure 1: Major Cardiac Events in the 3 Study Groups Conclusion: Our study showed the interest of the systematic evaluation of the systolic longitudinal function of the LV as well as the SGL since an alteration of these parameters influences the prognosis of patients with AS, which underlines the importance of incorporate GLS into AS evaluation algorithms.
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