CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 41 AFRICA Submission ID: 1560 BIOLOGICAL PREDICTIVE FACTORS OF IN-HOSPITAL MORTALITY IN CARDIOGENIC SHOCK IN THE SETTING OF STEMI SKANDER BOUCHNAG, AYOUB BELFKIH, MEJDI BEN MESSAOUD, NIDHAL BOUCHEHDA, MOHAMED MEHDI BOUSSAADA, MOHAMED MAJED HASSINE, MARWEN MAHJOUB, FETHI BETBOUT, HABIB GAMRA TUNISIA Introduction: Cardiogenic shock (CC) is considered a devastating complication of the ST elevation acute myocardial infarction (STEMI). Its mortality remains high although huge progress in critical care and coronary revascularization. Aim: We aim to determine the biological predictive factors of in-hospital mortality in CC complicating acute STEMI in the MIRAMI registry. Materials and methods: It is a retrospective, mono-centric study including 267 patients from the MIRAMI (Monastir Acute Myocardial Infarction) registry between 1995 and 2016. These patients presented a CC complicating a STEMI which occurred at admission or during their hospitalization. We studied the biological features of these patients and analyzed the predicting factors of their inhospital mortality. Results: The incidence of CC was 15%, mostly in men (77.9%). The mean age was 64.18 ± 12.5 years. Smoking was the most frequent risk factor (62.5%). Diabetes and hypertension occurred respectively in 44.9% and 34.5% of patients. The mean hemoglobin and creatinine rates were respectively 12.5 ± 2.3 g/dl and 142.2 ± 88.26 µmol/l. Anemia was found in 105 patients (39.3%) and significantly more often in the elderly (≥ 60 years) (p< 0.001). Renal failure was diagnosed in 159 patients (59.6%) mainly in women and the elderly (p< 0.001 respectively). Hyperglycemia was found in 163 patients (61%). Leukocytosis was found in 186 patients (69.9%). Elevated myocardial necrosis markers (CPK, LDH, and troponin) were found in most patients. In-hospital mortality was 49.1%. Biological predicting factors of in-hospital mortality in a univariate analysis were: anemia (p=0.001), renal failure (p<0.001), hyperuricemia (p=0.002), hyperglycemia (p<0.001), CPK > 500 mmol/l (p=0.04) and LDH > 5000 mmol/l (p=0.024). In a multivariate analysis, only renal failure was restrained as an independent predicting factor of in-hospital mortality (p< 0.001). Conclusions: The incidence of cardiogenic shock is significant with high inhospital mortality. The treatment strategy should be based on an urgent and multi-disciplinary approach taking into account all the biological abnormalities. Submission ID: 1564 ANEMIA AS A SEVERITY FACTOR IN PATIENTS WITH MYOCARDIAL INFARCTION HANANE CHOUKRANI, SARA ABOURADI, GHALI BENNANI, MED BENNOUNA, RACHIDA HABBAL MOROCCO Introduction: Anemia is well known as an independent risk factor in coronary patients. The objective of our work was to determine the relationship between hemoglobin levels and the evolution of patients admitted to the cardiology department of the Ibn Rochd University Hospital. Methods: 412 patients admitted to the cardiology department of Ibn Rochd hospital in Casablanca between July 2019 and December 2021 for ACS with or without ST segment elevation were included. The patients were subdivided into two groups: group 1 (n=135) with a hemoglobin level <11 g/dl and group 2 (n=277) with a hemoglobin level > 11 g/dl. Results: Among the 412 patients included, the mean age was 61 years, with a male predominance (74.7%). Renal function was more impaired in anemic patients with creatinine clearance at 54 ml per minute versus 83 ml per minute in non-anaemic patients. Patients in group 1 presented signs of left heart failure more frequently than those in group 2 (44% vs. 11%). Diastolic function was more often impaired with higher LV filling pressures in anemic patients (60% versus 25%). However, left ventricular systolic function did not appear to be affected by this rate, with an average ejection fraction (43% in group 1 versus 45% in group 2). Conclusion: Anemia on admission for ACS is linked to a poor prognosis. A fairly strong relationship is found between low hemoglobin values and the evolution of patients, particularly in terms of clinical or latent heart failure. Submission ID: 1574 ROLE OF THE INFLAMMATORY BIOMARKERS TO DETECTION OF THE CHRONIC PROGRESSION RHEUMATIC VALVULAR DISEASES: MOROCCAN EXPERIENCE OF THE CARDIOLOGY DEPARTMENT AT THE CHU IBN ROCHD, CASABLANCA H. BENDAHOU; S. ZAGDANE; M. AMRI; M. TAMIR; S. ABOURADI; K. BADAOUI; N. MALICK; S. ZAHRI ; N. MAHOUNGOUMACKONIA; M. HABOUB; S. AROUS; G. BENNOUNA; A. DRIGHIL; L. AZZOUZI; R. HABBAL MOROCCO Introduction: The pathogenic mechanisms of valvular rheumatism are complex and still poorly defined. Inflammatory biomarkers are increased in patients with rheumatic fever, but do they remain increased in the chronic phase? Objective: Determine the role of inflammation detected by serum biomarkers in the progression chronic rheumatic valvular. Methods: We conducted a prospective study, fromOctober 2017 to June 2022, on patients with valvular heart disease, at the cardiology department of the CHU Ibn Rochd. All patients underwent echocardiography MODERATED POSTER SESSION
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