AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 42 to assess valvular involvement, the degree of calcification and the mechanism of valvulopathy. Serum inflammatory markers: Fibrinogen (Fg), C-reactive protein (CRP), and Erythrocyte Sedimentation Rate (ESR) were measured in all patients. Patients with acute infection, underlying inflammatory disease, active cancer, or acute coronary artery disease were excluded. Results: During the 4 years of study, on a total of 720 patients with VHD, 530 patients were included. The mean age was 58.6 years, and a sex ratio (M/F) of 0.7. Mitral Regurgitation (48.9%) and Mitral Stenosis (46%) were the most frequent VHD. The rheumatic origin is the main cause of VHD in our context. We compared our valvular patients with a homogeneous group of healthy people (180 cases) without VHD and fulfilling the same exclusion criteria. The level of inflammatory markers was higher in patients with rheumatic VHD than in the healthy group. Thus, the CRP level was significantly elevated in 159 patients (30%) with a CRP >5mg/l, 92 patients (17.4%) had a ESR>20mm and 120 patients (22.6%) had a Fibrinogen>4g/l, according to laboratory standards of the CHU IBN Rochd Hospital. No correlation was observed between age or sex with the level of the markers measured. Conclusion: The chronic phase of rheumatic VHD is associated with an increase in inflammatory mediators correlated with the severity of the valve disease and with calcifications. And testify to the persistence of inflammation in the chronic phase. These results influence the management of chronic rheumatic valvular. Submission ID: 1579 QSOFA SCORE: A USEFUL SCORE TO IDENTIFY PATIENTS AT RISK OF POOR PROGNOSIS IN INFECTIVE ENDOCARDITIS MAAROUFI ANASS, BENANNI GHALI, KHALDI MOHAMMED, HABOUB MERIEM, AROUS SALIM, BENOUNA EL GHALI, AZZOUZI LEILA, DRIGHIL ABDENNACER, HABBAL RACHIDA MOROCCO Introduction: According to the VIRSTA study, about sixty percent of infectious endocarditis (IE) are complicated by sepsis. The qSOFA score is used to identify patients with a high risk of adverse outcome following their infection. Thus, our study aims to evaluate the predictive performance of qSOFA as a prognostic tool to identify those with IE at high risk for early poor outcome. Methods: This is a 6-years monocentric retrospective cohort study, included patients admitted for IE between 2017 and 2022 according DUKE criteria, with initiation of anti-bacterial therapy. The qsofa score was calculated for each patient and a score of ≥ 2 points was used as the prognostic cutoff value in predicting clinical deterioration and death within 30 days. Results: Overall, on a total of 123 patients, demographics showed the mean age of 40 years, sex-ratio 1.4. Twenty five percent had qsofa ≥ 2 and were considered the high qSofa group. A higher proportion of low qSOFA patients (10% vs 2%, p= 0.023) had no pre-existing comorbid condition. The high qSOFA group were more likely to be infected with Staphylococcus aureus. The high qSOFA group had higher rate of persistently clinical and biologic infectious syndrome despite receipt of ≥ 4 days of effective therapy (34% vs 20%, p= 0.0039), higher rate of 30-day mortality (19% vs 3%, p < 0.05), and a longer length of hospitalization compared to the low qSOFA group (p= 0.01). Conclusion: Our findings are consistent with those from prior studies involving other infectious syndrome. The qSOFA score could be used as prognostic factor in IE and patients identified with high score should receive aggressive management in particular in Staphylococcus aureus etiology. Submission ID: 1581 THE IMPACT OF LEFT VENTRICULAR GEOMETRY IN RIGHT HEART FUNCTION IN HYPERTENSIVE PATIENTS MARWA ABDELHEDI, SARRA CHENIK, AYMEN NOAMEN, TAHA YASSINE JABLOUN, ABDEDDAYEM HAGGUI, WAFA FEHRI TUNISIA Background: The right atrium (RA) reflects the right ventricular (RV) diastolic function due to its relation with RV filling pressure, which is particularly important for the hypertensive patients who frequently have biventricular diastolic dysfunction. Only few studies have investigated RV deformation and function and RA reservoir function in hypertensive patients with different left ventricular (LV) geometry patterns. Purpose: To evaluate RV function and RA reservoir function in hypertensive subjects with various LV geometric patterns using the classification for LV geometry according to updated guidelines. Methods: This cross-sectional prospective study included 60 hypertensive patients who underwent complete 2D echocardiography. Using LV mass index and relative wall thickness (RWT) according to the updated classification, all subjects were divided into two groups: with and without left ventricular hypertrophy (LVH) and were then divided into four groups according to different LV geometry patterns: normal LV geometry, concentric remodeling, eccentric LVH and concentric LVH. Speckle-tracking strain analyses of the RA and RV were performed: Global RV longitudinal strain was determined for the whole RV, including interventricular septum. Peak RA strain values from six segments using speckle-tracking software were averaged, representing RA reservoir function. Results: Right atrial volume evaluated by 2DE was higher in hypertensive patients with LVH than in individuals with normal LV geometry or concentric remodeling with p= 0,03. RV longitudinal strain and RA peak longitudinal strain were significantly decreased in concentric LVH pat compared with other hypertensive groups with p= 0,003 and p=000,9 respectively. Gradual deterioration of RV longitudinal function from patients with normal LV geometry and concentric remodeling to patients with concentric LVH was missed due to relatively small sample size. Conclusion: Left ventricular geometric patterns have significant impact on right heart function in hypertensive patients. Concentric LVH patterns have the most prominent negative effect on RA and RV morphological and functional remodeling MODERATED POSTER SESSION
RkJQdWJsaXNoZXIy NDIzNzc=