CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 51 AFRICA infarction (STEMI). The pharmacoinvasive strategy (PIs) is a reasonable alternative when prompt PAMI is not possible, especially in areas where percutaneous coronary intervention centers are not readily available. This study assessed the feasibility of PIs under local conditions. Methods: This was a retrospective case-control observational study of 103 patients in a Tunisian center of Gabes, (southeast). We compared the clinical and angiographic characteristics, and in-hospital outcomes of patients undergoing PAMI during the first 12 h and those receiving a PIs. Results: We identified 75 and 28 consecutive patients enrolled in pharmacoinvasive and PAMI strategies, respectively. There were no differences between PIs and PAMI in terms of age (58 years vs. 61 years, p= 0.966), respectively. There were no differences between PIs and PAMI in terms of coexisting cardiovascular risk factors: Hypertension (36% vs 32 % p = 0.715), Diabetes mellitus (51% vs 56% p = 0.665), History of dyslipidemia (34% vs 36% p= 0.862), Current smoker (56% vs 50% p= 0.586), respectively. The median door-to-needle time was 37 min in the pharmacoinvasive group and the median door-to-balloon time was 91 min in the PAMI group (p= 0.009 ). TIMI flow grade 3 at baseline was present in 80% of patients in the pharmacoinvasive group and 3.6% of patients in the PAMI group. After the procedure, the proportion of TIMI flow grade 3 became 93.3% and 85.7%, respectively. There were no differences between PIs and PAMI in terms of total in-hospital mortality (5.3% vs. 3.6%, p = 0.711), heart failure (16% vs. 17.9%, p = 0.821), major bleeding (0% vs. 3.6%, p = 0.1) or component major adverse cardiac events (MACE) (16% vs 21.4%, p= 0.519) Conclusions: Within the context of a STEMI management, a pharmacoinvasive strategy was associated with similar in-hospital rates of mortality, heart failure, major bleeding, or component major adverse cardiac events (MACE) as compared with a primary angioplasty in myocardial infarction strategy. Submission ID: 1643 NONINVASIVE CARDIOVASCULAR EVALUATION OF PATIENTS WITH ERECTILE DYSFUNCTION CHENIK SARRA, NOEMEN AYMEN, JABLOUN TAHA YASSINE, HAGGUI ABDEDDAYEM, HAJLAOUI NADHEM, FEHRI WAFA TUNISIA Introduction: Erectile dysfunction (ED) is now recognized in most cases to be of vascular cause, with endothelial dysfunction as the main pathophysiological mechanism. ED was considered as a marker for an asymptomatic cardiovascular disease (CVD). Two-dimensional speckle tracking echocardiography seems to be a novel technique used to detect subclinical cardiovascular disease. Objective: The aim of this study was to evaluate the role of two-dimensional speckle-tracking for noninvasive evaluation in patients with erectile dysfunction. Methods: This was a prospective observational study carried out from June 2020 to march 2022, including all patients with organic erectile dysfunction referred to our cardiology consultation from the department of urology. Epidemiological and clinical characteristics were investigated. The severity of ED was evaluated using the International Index of Erectile Function (IIEF5). A complete physical examination was performed for all subjects. Myocardial deformation analysis by 2D-STE was performed for all patients. The study was conducted after the approval of the local ethics comity. Results: We included 109 patients with a mean age of 59 years +/- 7.9. The severity of erectile dysfunction was mild in 10.1%, moderate in 46.8% and severe in 42.2% of the cases. Analyses revealed that there was a significant correlation between hypertension, hyperlipidemia, diabetes mellitus, sedentary lifestyle and severe ED (p=0.056; p=0.013; p=0.058 and p=0.075, respectively). One third of the patients (33%) with severe ED had a history of coronary artery disease confirmed by angiography. Moreover, correlation analysis revealed a significant correlation of GLS-LV values with severe ED (p=0,001 and p=0,054 respectively). Conclusion: Myocardial deformation parameters by 2D-STE is noninvasive methods that may be used as an emerging prognostic marker to detect subclinical cardiovascular diseases. Submission ID: 1644 LONG-TERM OUTCOMES IN CONGENITALLY CORRECTED TRANSPOSITION OF THE GREAT ARTERIES: LA RABTA HOSPITAL EXPERIENCE KAOUTHAR HAKIM, ELLA LAHMAIER, RIHAB BEN OTHMEN, SABRINE SOUDANI, AMIRA TALHAOUI, SYRINE BEN JEDDOU, HELA MSAAD, FATMA OUARDA TUNISIA Background: Congenitally corrected transposition of great arteries (ccTGA) is a rare and complex congenital heart disease. It can occur in isolation or in combination with other structural cardiac anomalies. Decision making for management strategies of ccTGA depends on the age, type, severity of the associated lesions and local surgical experience. Objective: The aim of our study was to determine long-term outcome in operated and non-operated patients with ccTGA. Methods: Monocentric retrospective review of patients with a diagnosis of ccTGA in the cardiopediatric departement of la Rabta hospital. Anamnestic, clinical data, electrical data and therapeutic stragegies were characterized at the time of diagnosis and during follow-up. Results: Fifty-five patients were included. The mean age of our patients was 13 years, with extremes ranging from 7 days to 58 years. Sex ratio was 1,8. Twenty-three patients were operated. Palliative surgery was performed in 20 patients. Eight patients underwent surgical repair: five patients have physiologic repair and three have anatomic repair. Median follow-up in our population was 10 years with extremes ranging from one week to 36 years. Six patients were lost to followup. In non-operated group, moderate to severe systemic regurgitation was noted in 56% of patients. Two patients with mild tricuspid regurgitation carried pregnancy to termwithout major complications. Twelve percent of cases presented heart failure with dysfunction of the systemic ventricle; among them, one patient had cardiac transplantation. Complete heart bloc occurred in eight patients. In operated patients, moderate to severe systemic regurgitation was found in 24% patients. Heart failure developed in 16% of cases. One patient with severe Systemic regurgitation carried pregnancy to term. Post partum period was affected by acute heart failure. MODERATED POSTER SESSION
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