AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SAHS Biennial Congress 16-18 September 2022 16 Submission ID: 1344 Introduction Low- and middle-income countries experience an increasing burden of chronic kidney disease. Cardiovascular risk factors, including advancing age, may contribute to this phenomenon. We i) profiled cardiovascular risk factors (age, adiposity, blood pressure, glucose, lipid profiles and lifestyle factors) and biomarkers of kidney function (in young adults aged 20-30 years); and ii) investigated whether these biomarkers differed across age groups. Methods Biomarkers of kidney function, including estimated glomerular filtration rate (eGFR), urinary albumin-to-creatinine ratio, alpha-1 microglobulin, neutrophil gelatinase-associated lipocalin (NGAL), uromodulin and the CKD273 urinary proteomics classifier, were used to divide the total population into quartiles to compare extremes (25th percentiles) on the normal kidney function continuum. The lower 25th percentiles of eGFR and uromodulin and the upper 25th percentiles of urinary albumin-to-creatinine ratio, alpha-1 microglobulin, NGAL, and the CKD273 classifier represented the more unfavourable kidney function groups. Results In the more unfavourable kidney function groups, adiposity markers and blood pressure were higher and adverse lipid profiles (all p<0.05) were present. Age was only higher in the more unfavourable eGFR and CKD273 classifier groups (all p<0.001). In the total group, eGFR declined while the CKD273 classifier score increased with increasing age (both p-trend <0.05). Lower eGFR (p<0.001) and NGAL (p<0.05) levels increased the odds of being in the upper CKD273 classifier percentile. Conclusion Even in a young and healthy cohort a more unfavourable kidney function profile was associated with cardiovascular risk factors. Name: Presenting Author Information Article Category Abstract Title Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa degenaaranja@gmail.com English Abstract Basic Sciences Cardiovascular risk and kidney function profiling using conventional and novel biomarkers in young adults: The African-PREDICT study Author Affiliation: Email: Anja Degenaar Upload your slides or pictures illustrating the case ORAL PRESENTATION
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