AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SAHS Biennial Congress 16-18 September 2022 18 Submission ID: 1345 Authors Name & Surname Title Expertise Affiliation Email Country Donavan Rooi Mr Cardiovascular Physiology NWU HART rooi860@gmail.com South Africa Prof Shani BothaLe Roux Prof Cardiovascular Physiology NWU HART and MRC Research Unit for Hypertension and Cardiovascular Disease, NWU, North-West Province, South Africa shani.botha@nwu.ac.za South Africa Yolandi Breet Dr Cardiovascular Physiology NWU HART and MRC Research Unit for Hypertension and Cardiovascular Disease, NWU, North-West Province, South Africa 21195706@nwu.ac.za South Africa Introduction Hypertension and increased blood pressure can cause pathophysiological changes that result in subclinical target-organ damage (TOD). Pulsatile pressure (pulse pressure (PP)) has been associated with cardiovascular disease (CVD) but research is incongruent regarding the association of perfusion pressure (mean arterial pressure (MAP)) with CVD. Furthermore, limited literature exists on the strength of associations between different pressure measures with subclinical TOD, especially in young populations. Thus, the researchers aimed to compare the strength of associations of subclinical TOD markers with perfusion and pulsatile pressure in young South African adults. Methods This study included 1 187 young (aged 20-30 years), normotensive black and white participants from the African-PREDICT study. Twentyfour-hour MAP and 24-hour PP measurements were obtained, as well as measures of subclinical TOD: echocardiography, to determine left ventricular mass index (LVMi), carotid intima-media thickness (cIMT) with ultrasound, carotid-femoral pulse wave velocity (cfPWV) using a femoral cuff and applanation tonometry, central retinal arteriolar equivalent (CRAE) from fundus images and albumin to creatinine ratio (ACR) determined from spot urine samples. Results Stronger correlations were found between cIMT, cfPWV, and CRAE with perfusion pressure (all p<0.001) when compared to pulsatile pressure. Stronger independent associations were found with cfPWV (adjusted R2=0.26) and CRAE (adjusted R2=0.12) with perfusion pressure (all p≤0.001) when compared to pulsatile pressure. Conclusion In young, healthy adults, perfusion pressure correlated stronger with subclinical TOD markers when compared to pulsatile pressure. Name: Presenting Author Information Article Category Abstract Title North-West University HART rooi860@gmail.com English Abstract Basic Sciences Perfusion and pulsatile pressure and the relationship with target organ damage: The African-PREDICT study Author Affiliation: Email: Donavan Rooi Upload your slides or pictures illustrating the case ORAL PRESENTATION
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