CARDIOVASCULAR JOURNAL OF AFRICA • SAHS Biennial Congress 16-18 September 2022 19 AFRICA Submission ID: 1346 Authors Name & Surname Title Expertise Affiliation Email Country Shani Botha-Le Roux Prof cardiovascular physiology, inflammation, risk factors, biomarkers, vascular disease Medical Research Council: Unit for Hypertension and Cardiovascular Disease, Hypertension in Africa Research Team (HART), North-West University, South Africa shani.botha@nwu.ac.za South Africa Edrich van Zyl Mr cardiovascular physiology Hypertension in Africa Research Team (HART), North-West University, South Africa lycanunity@gmail.com South Africa Ruan Kruger Prof pediatric hypertension, premature cardiovascular disease development Medical Research Council: Unit for Hypertension and Cardiovascular Disease, Hypertension in Africa Research Team (HART), North-West University, South Africa ruan.kruger@nwu.ac.za South Africa Lebo F GafaneMatemane Prof cardiovascular disease, renin-angiotensinaldosterone system, kidney physiology Medical Research Council: Unit for Hypertension and Cardiovascular Disease, Hypertension in Africa Research Team (HART), North-West University, South Africa lebo.gafane@nwu.ac.za South Africa Introduction The role of endothelial activation in atherosclerosis is known, but limited studies exist on endothelial activation in asymptomatic individuals. We investigated the relationship between carotid arterial stiffness and markers of endothelial activation in young healthy adults. Methods We included 1197 individuals with a median age of 24 years (25th & 75th percentiles: 22 27). Carotid strain, distensibility, compliance, beta-stiffness index (BSI), Peterson’s elastic modulus (PEM), Young’s elastic modulus (YEM) and carotid intima-media thickness (cIMT) were determined from B-mode ultrasonography. Intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), P-selectin and monocyte chemoattractant protein 1 (MCP-1) were analysed. Results VCAM-1 was highest and P-selectin lowest in the lowest tertile of strain, distensibility and compliance, and in the highest tertile of BSI, PEM and YEM (all p≤0.028), but not cIMT. In multivariable-adjusted and binomial logistic regression analyses, stiffness measures associated with higher VCAM-1 [strain (β=-0.14, OR=0.73); distensibility (β=-0.12, OR=0.72); compliance (β=-0.11, OR=0.76); BSI (β=0.10, OR=1.32); PEM (β=0.10, OR=1.30) YEM (β=0.10, OR=1.25); all p≤0.001] and higher ICAM-1 [compliance (β=-0.06), strain (OR=0.88); all p≤0.045], but lower P selectin [strain (β=0.10, OR=1.17); distensibility (β=0.08, OR=1.18); compliance (β=0.09); BSI (β= 0.11, OR=0.82); PEM (β=-0.09, OR=0.82); YEM (β= 0.09, OR=0.85); all p≤0.016] as well as lower MCP-1 [strain (β=0.07); distensibility (β=0.06, OR=1.17); compliance (β=0.08, OR=1.23); BSI (β= 0.07, OR=0.85); YEM (β=-0.06, OR=0.86); all p≤0.043]. Conclusion We found adverse relationships between measures of carotid arterial stiffness and markers of endothelial activation in healthy adults, suggesting that the development of arterial stiffness may be mediated by early onset endothelial activation. Name: Presenting Author Information Article Category Abstract Title Medical Research Council: Unit for Hypertension and Cardiovascular Disease, Hypertension in Africa Research Team (HART), North-West University, South Africa shani.botha@nwu.ac.za English Abstract Basic Sciences Carotid arterial stiffness associates with endothelial activation in young adults: The African-PREDICT study Author Affiliation: Email: Prof Shani Le Roux ORAL PRESENTATION
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