AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SAHS Biennial Congress 16-18 September 2022 38 Submission ID: 1386 Introduction The soluble (pro)renin receptor [s(P)RR], a receptor for both prorenin and renin is associated with kidney dysfunction, possibly due to its proinflammatory and profibrotic effects. s(P)RR is elevated in individuals with hypertension, type 2 diabetes, preeclampsia and chronic kidney disease, with evidence of ethnicity- and sex-specific differences. Despite being known as part of the renin-angiotensin system (RAS) for the past two decades, studies on the role of s(P)RR in kidney function remain scant, particularly in young healthy populations. The aim of the current study was to compare s(P)RR and markers of kidney function between black and white participants grouped according to sex and investigate associations of estimated glomerular filtration rate (eGFR), urinary albumin-creatinine ratio (uACR) and alpha 1-microglobulin (A1M) with s(P)RR in young black and white men and women. Methods We included apparently healthy black (men, N=283; women, N=301) white (men, N=297; women, N=310) participants aged 20-30 years. Participants were normotensive at screening (clinic blood pressure <140/90 mmHg). We recorded 24-hour blood pressure and measured albumin and creatinine in urine and calculated uACR. Creatinine, s(P)RR and A1M were measured in serum and eGFR was calculated. Results eGFR was higher in both black men and women as compared to white men and women, while uACR was higher in black men compared to white men ((all P≤0.006). A1M was higher in white women compared to black women (P=0.001). s(P)RR was higher in both white men and women as compared to their black counterparts (both P≤0.001). After multiple adjustments for covariates, an independent positive association was observed between A1M and s(P)RR in white women only (Adjusted R-squared=0.130; β=0.195; P=0.007). There were no associations of eGFR and uACR with s(P)RR in any of the groups. Conclusion We found higher s(P)RR levels in young healthy white men and women as compared to their black counterparts. In this group of white women, s(P)RR associated positively with A1M, a marker of kidney function known to be upregulated by oxidative stress, and not with conventional markers of kidney function. Our results suggest that s(P)RR activation may contribute to kidney damage through inflammation and oxidative stress in young white women. Name: Presenting Author Information Article Category Abstract Title North-West University, Hypertension in Africa Research Team lebo.gafane@nwu.ac.za English Abstract Basic Sciences Associations between kidney function and the soluble (pro)renin receptor in young adults: The African-PREDICT study Author Affiliation: Email: Lebo F Gafane-Matemane Authors Name & Surname Title Expertise Affiliation Email Country Lebo F GafaneMatemane A/Prof Cardiovascular Physiology North-West University, Hypertension in Africa Research Team lebo.gafane@nwu.ac.za South Africa Phuti J Mokgonyana Miss Cardiovascular Physiology North-West University, Hypertension in Africa Research Team mokgonyanaphuti@gmail.com South Africa Gontse G Mokwatsi Dr Cardiovascular Physiology North-West University, Hypertension in Africa Research Team gontse.mokwatsi@nwu.ac.za South Africa ORAL PRESENTATION
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