AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SAHS Biennial Congress 16-18 September 2022 42 Submission ID: 1356 Introduction The prevalence of type 2 diabetes mellitus (T2DM) has more than doubled since the 1980s. Diabetes increases the risk of new heart failure (HF) by a factor of 2-5 in a Framingham study. The left ventricular (LV) dysfunction associated with diabetes is multifactorial, however, myocardial damage resulting from chronic metabolic disturbances and systemic inflammation is a major contributor to the progressive development of cardiomyopathy until symptoms appear. Screening for heart failure in patients at risk can detect the condition and predict outcomes. Thus, we sought to understand the associations between impaired left ventricular systolic-diastolic function in patients with T2DM. Methods A total of 108 patients with at least one risk factor for HF (hypertension, obesity or T2DM) were recruited from two community populations and divided into two groups: T2DM (n = 68, age 61 ± 8 years) and non-T2DM (n =40, age 62 ± 10 years). Treatment combinations with metformin were assessed in the T2DM group. Full echocardiography was performed in all patients including global longitudinal strain (GLS) and diastolic function (transmitral flow [E], annular velocity [e’]) at baseline and at follow-up (median 5 months). Results A reduction in GLS was observed in the T2DM group (baseline -16.5 ± 2.5% versus follow-up -16 ± 2.3%; p = 0.003), but not in the nonT2DM group (-18 ± 2.5% versus -17.6 ± 2.4%; p = 0.01). Estimated left ventricular filling pressures increased in both the T2DM group (p = 0.001) and the non-T2DM group (p = 0.01). Name: Presenting Author Information Article Category Abstract Title Cardiologie maschellmahoungou@gmail.com English Abstract Clinical Assessment of left ventricular systolic and diastolic function in patients with asymptomatic Type 2 diabetes Author Affiliation: Email: Mahoungou Mackonia Noel Maschell Authors Name & Surname Title Expertise Affiliation Email Country Mahoungou Mackonia Noel Maschell Résident Cardiologie CHU Ibn Rochd,Casablanca maschellmahoungou@gmail.com Morocco POSTER PRESENTATION
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