CARDIOVASCULAR JOURNAL OF AFRICA • SAHS Biennial Congress 16-18 September 2022 43 AFRICA Submission ID: 1340 Introduction The concurrent use of multiple medications (Polypharmacy) has been shown to increase admissions to the hospital, and mortality due to interactions. Several components contribute to polypharmacy e.g. multiple prescriptions from different prescribers, as well as selfmedication. This results in duplication of therapy, drug-drug interactions and disease-drug interactions. Aims of the study are to Improve Patient Safety, Improve Compliance , Minimise Pharmaceutical Wastage and to Develop Strategies to Improve Polypharmacy. Methods Study Design. This was an observational study at a public hospital. Medscape’s Interaction checker was used to verify interactions. Study population. Patients on chronic medication serviced by the hospital. Sample Size. 250 prescriptions were randomly selected over 3 years. Results The following drug interactions were observed: a. Amitriptyline and Indapamide: both increase QTc interval. This may increase risk of sudden death in elderly population. b. Perindopril and Allopurinol: There is a high risk of developing an anaphylaxis and Stevens Johnson Syndrome. c. Perindopril and Pregabalin: Co-administration results in additive risk of developing angioedema of the face, neck and mouth. Conclusion The study found numerous drug-drug interactions, disease-drug interactions and unused medicines returns. Periodic review of prescriptions with an intent to de-prescribe is recommended. Name: Presenting Author Information Article Category Abstract Title South African Military Health Services (SAMHS) preciousncayiyana@gmail.com English Abstract Clinical Deprescribing to Improve Polypharmacy Author Affiliation: Email: Miss Precious Ncayiyana Authors Name & Surname Title Expertise Affiliation Email Country Precious Ncayiyana Miss Pharmacist SAPC, SASOCP, SAMHS preciousncayiyana@gmail.com South Africa POSTER PRESENTATION
RkJQdWJsaXNoZXIy NDIzNzc=