CARDIOVASCULAR JOURNAL OF AFRICA • SAHS Biennial Congress 16-18 September 2022 45 AFRICA Submission ID: 1342 Introduction Diabetes mellitus (DM) and coronary artery disease (CAD) are associated with significant morbidity and mortality. The rising incidence of these non-communicable conditions and the subsequent complications, especially in developing nations, has highlighted the need for improved treatment strategies. This retrospective observational study investigated the role of admission glycated hemoglobin A1c (HbA1c) and its relation to major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI) during hospitalization and six months’ follow-up. Methods The study cohort included 1000 patients with AMI who had been admitted to the coronary care unit (CCU) of RK Khan Hospital, Durban, South Africa from December 2016 to March 2018. The demographic, clinical and biochemical data for these patients were obtained from an electronic database and divided into three categories according to HbA1c levels: low (<5.7), medium (5.7-6.4) and high (>=6.5). Results The mean age of the study population was 56.7 with majority (71.6%) being males. Diabetic patients comprised 74.9% of the study cohort, 17.7% of whom were newly diagnosed based on HbA1c levels. There were 26.8% of patients that experienced MACE with cardiac failure occurring most frequently (12.6%; p=0.03). Greatest incidence of MACE was observed in the group with lowest HbA1c (33.1%; p=0.051). Although multivariable logistic regression analyses showed diabetes mellitus, hyperuricemia and family history of CAD to be significantly associated with MACE, no correlation was noted between HbA1c values and MACE. Conclusion This study shows that diabetes mellitus is the most common risk factor for AMI. Admission HbA1c is of value in detecting undiagnosed diabetes and excluding stress hyperglycemia as a cause of elevated admission glucose levels. Patients with low HbA1c had the highest incidence of MACE with cardiac failure occurring most frequently. This highlights the negative effects of hypoglycemia and the need to prevent it. However, this study shows that admission Hba1c is not predictive of in hospital and short-term MACE in AMI patients and further research is required in this area. Name: Presenting Author Information Article Category Abstract Title MMed student of Prof. N. Ranjith dhayanee504@gmail.com English Abstract Clinical The Value of Admission HbA1c in patients with Acute Myocardial Infarction Author Affiliation: Email: Dr Dhayanee Sigamoney-Mudaly Authors Name & Surname Title Expertise Affiliation Email Country Dhayanee SigamoneyMudaly Dr Physician MMed student of Prof. N. Ranjith dhayanee504@gmail.com South Africa POSTER PRESENTATION
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