AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SAHS Biennial Congress 16-18 September 2022 48 Submission ID: 1348 Introduction Early onset hypertension has been linked with changes in cardiovascular structure and function, whereas antioxidant intake may have beneficial effects against cardiovascular disease. Therefore, we aimed to determine the associations of left ventricular mass index (LVMI), relative wall thickness (RWT) and systemic vascular resistance (SVR) with selenium (an essential micronutrient with antioxidant properties) in young adults stratified as normotensive or masked hypertensive. Methods In 1126 young adults, aged 20-30 years, we determined echocardiographic measurements including LVMI and RWT, calculated SVR and performed biochemical analyses to determine serum selenium levels by inductively coupled plasma mass spectrometry. Results The study population had a mean age of 24.6 years with a normal mean selenium level of 13.3 μg/100ml serum with no significant difference (all p≥0.57) between normotensive (n=928) and masked hypertensive (n=198) participants. In backward stepwise multivariable adjusted regression analysis, a beneficial relationship of LVMI (adj. R2=0.19; β=–0.091; P=0.004), RWT (adj. R2=0.096; β=–0.18; P<0.001) and SVR (adj. R2=0.24; β=–0.12; P<0.001) with selenium was observed in normotensive but not in masked hypertensive participants. Conclusion Independent inverse associations of LVMI, RWT and SVR with selenium, in young, normotensive adults suggest that sufficient selenium levels may protect against the early development of left ventricular remodelling and increased vascular resistance, however this cardioprotective role of selenium is attenuated in the setting of masked hypertension. Name: Presenting Author Information Article Category Abstract Title Hypertension in Africa Research Team (HART), Faculty of Health Sciences, North-West University, Potchefstroom, South Africa 21195706@nwu.ac.za English Abstract Population Sciences Selenium and cardiovascular protection in young adults: The African-PREDICT study Author Affiliation: Email: Dr Yolandi Breet Upload your slides or pictures illustrating the case POSTER PRESENTATION
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