AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SAHS Biennial Congress 16-18 September 2022 50 Submission ID: 1349 Background Even though there are higher levels of hypertension among South African adults, a chronic condition that is associated with early vascular aging and cognitive impairment, there is a paucity of studies that investigate this relationship. Aims To determine the association between blood pressure, arterial stiffness, and cognitive function in younger (29 yrs) and older adults (>47 yrs) from an urban South African cohort study. Methods A complete cross-sectional case study of n= 93 young adults (index children) and their mothers from the Birth-to-Twenty Plus cohort was conducted. Peripheral and central blood pressure (BP) measurements were collected, mean arterial pressure (MAP) was calculated and an augmentation index was derived. Carotid-femoral pulse wave velocity (cfPWV), which reflects local arterial stiffness and has a direct impact on cerebral circulation was measured with applanation tonometry. Cognitive assessments were conducted using the Montreal Cognitive Assessment (MoCA) instrument were conducted to get a total test score and various domain-specific scores. Multiple logistic regressions to determine the association between the BP variables, global cognitive, and specific domains test scores were conducted. Results Forty percent of the sample had low MoCA total scores, and 32% of the total sample had hypertension [BP ≥140/90 mmHg (brachial)]. Significant differences between means of central pulse pressure, augmentation pressure, and cfPWV for the low and normal visual perception MoCA domain test scores were observed (p<0.05). Only cfPWV mean difference was observed for the low and normal verbal fluency MoCA domain. No associations were found between BP measurements and total MoCA scores (p<0.01). Also, no associations were found between peripheral and central BP variables with individual MoCA domains when stratified by age. A significant relationship was found between mean pressure (OR 1.47 95% CI [1.07-2.07]) and one MoCA domain (low visual perception). Conclusion Central mean pressure is associated with low visual perception MoCA domain among black women. These findings add to the growing evidence which suggests that central BP variables are important to explore as exposure proxies for studying the association between BP measurements and cognitive dysfunction, especially among younger and older adults. Name: Presenting Author Information Article Category Abstract Title DSI-NRF Centre for Excellence in Human Development, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa feziwester@gmail.com English Abstract Population Sciences Association between central blood pressure and arterial stiffness and low cognitive scores in South African adults Author Affiliation: Email: Dr Feziwe Mpondo Authors Name & Surname Title Expertise Affiliation Email Country Feziwe Mpondo Dr Health Psychology and Public Health DSI-NRF Centre of Excellence in Human Development, University of the Witwatersrand, Johannesburg, South Africa. feziwester@gmail.com South Africa Ashleigh Craig Dr Health Psychology and Public Health SAMRC/Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa ashcraig92@gmail.com South Africa Andrea KolkenbeckRuh1 Dr Health Psychology and Public Health SAMRC/Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa andrea.kolkenbeck-ruh@wits.ac.za South Africa POSTER PRESENTATION
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