CARDIOVASCULAR JOURNAL OF AFRICA • SAHS Biennial Congress 16-18 September 2022 65 AFRICA Submission ID: 1385 Introduction L-homoarginine is an endogenous homologue of L-arginine that has been proposed as an alternative substrate for the synthesis of nitric oxide (NO). We investigated the associations of L-homoarginine with hypertension, carotid wall thickening, and cardiovascular-related mortality. Methods We measured plasma L-homoarginine concentrations using liquid chromatography-tandem mass spectrometry in n=669 South African participants from the Prospective Urban and Rural Epidemiology study (mean age 59.5 years). Associations of plasma L-homoarginine were investigated with (i) blood pressure in incident hypertension after 10-years; (ii) carotid wall thickening as indicated by carotid intimamedia thickness (cIMT) and cross-sectional wall area (CSWA); and (iii) both cardiovascular and all-cause mortality. Results In multivariable regression analyses, baseline L-homoarginine positively associated with brachial systolic blood pressure (β=0.33; p=0.001), brachial pulse pressure (β=0.40; p=0.001), and central pulse pressure (β=0.30; p=0.003) in the group that remained normotensive after 10 years. In the group that developed hypertension after ten years, no significant associations were found. In the total group, follow-up cIMT (β=-0.10 p=0.018) and CSWA (β=-0.12; p=0.004) inversely associated with baseline L-homoarginine. During a median follow-up of 9.8 years, n=143 participants died, of which n=40 was cardiovascular-related. Higher baseline plasma L-homoarginine was associated with lower cardiovascular (hazard ratio per SD increment=0.61; 95%CI: 0.50-0.75) and all-cause (hazard ratio per SD increment=0.59; 95%CI: 0.41-0.84) mortality risk. Conclusion Our findings suggest a protective role of L-homoarginine against the development of hypertension, carotid wall thickening and both cardiovascular and all-cause mortality. Regulation of L-homoarginine levels as a therapeutic target in the management of CVD should be further investigated. Name: Presenting Author Information Article Category Abstract Title Hypertension in Africa Research Team Cleo.Mokhaneli@nwu.ac.za English Abstract Basic Sciences L-homoarginine, cardiovascular function and mortality risk in Black South Africans Author Affiliation: Email: Maserame Cleopatra Mokhaneli Authors Name & Surname Title Expertise Affiliation Email Country Maserame Cleopatra Mokhaneli Dr Hypertension in Africa Research Team Cleo.Mokhaneli@nwu.ac.za South Africa Shani Botha-Le Roux Prof Hypertension in Africa Research Team Shani.Botha@nwu.ac.za South Africa Carina Mels Prof Hypertension in Africa Research Team Carina.Mels@nwu.ac.za South Africa POSTER PRESENTATION
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