AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SAHS Biennial Congress 16-18 September 2022 66 Submission ID: 1388 Background Obesity is a strong predictor for the development of cardiovascular diseases. Despite this fact, there are some reports of paradoxically better prognosis among obese patients. Purpose We sought to evaluate the differences in angiographic characteristic, early and long-term in patients with stable angina (SA) depending on body mass index (BMI) intervals. Methods A total of 6880 consecutive patients with available BMI value from the PRESAGE Registry were analyzed. In brief, the PRESAGE Registry is an ongoing, single-center, prospective observational study recruiting consecutive patients with SA. Study population was divided depending on BMI intervals: underweight - <18.50 kg/m2; normal weight - 18.50–24.99 kg/m2; overweight - 25.00–29.99 kg/m2; 1-st degree obesity - 30.00–34.99 kg/m2; 2-nd degree obesity - 35.00–39.99 kg/m2; 3-rd degree obesity - >40.00 kg/m2. The main outcome measure was 36-month all-cause death, non-fatal myocardial infarction and acute coronary syndrome (ACS)-driven revascularization. Results The percentage of study population depending on BMI intervals were respectively: 0.6% for underweight, 20.3% for normal weight, 45.3% for overweight, 25.7% for 1-st degree obesity, 6.7% for 2-nd degree obesity and 1.4% for 3-rd degree obesity. With higher BMI value, an occurrence of hypertension, hypercholesterolemia and diabetes mellitus were increasing. Patients in the underweight group had the lowest left ventricular ejection fraction and frequency of prior heart failure. The angiographic characteristics and treatment were comparable in analyzed groups with exception for lower rate of revascularization in underweight patients. In-hospital and early-term outcomes were similar in analyzed groups. At 36-month patients with 1-st degree obesity had the lowest, while underweight and 3-rd degree obesity were associated with the highest rates of mortality (26.7% for underweight, 12.1% for normal weight, 10.8% for overweight, 8.0% for 1-st degree obesity, 10.1% for 2-nd degree obesity and 17.2% for 3-rd degree obesity; P=0.0006). Incidence of MI and ACS-driven revascularization were comparable in analyzed groups. In Cox proportional hazards model, 1-st degree obesity was an independent factor of favorable 3-year mortality (hazard ratio 0.71; 95% confidence interval 0.57–0.89; P=0.0035). Conclusion In PRESAGE Registry, the obesity paradox in 36-month mortality was confirmed. 1-st degree obesity is an independent predictor of favorable long-term mortality. Name: Presenting Author Information Article Category Abstract Title CHU Ibn Rochd, Casablanca, Morocco meryelmousaid@gmail.com English Abstract Clinical Obesity paradox in patients with stable angina Author Affiliation: Email: Meriem EL Mousaid Authors Name & Surname Title Expertise Affiliation Email Country Meriem EL Mousaid Résidente Cardiologie CHU Ibn Rochd, Casablanca meryelmousaid@gmail.com Morocco Hanaa Charif Résidente Cardiologie CHU Ibn Rochd, Casablanca Morocco Asmaa Elamraoui Résidente Cardiologie CHU Ibn Rochd, Casablanca Morocco Amine Errami Résident Cardiologie CHU Ibn Rochd, Casablanca Morocco Hatim Hajar Résidente Cardiologie CHU Ibn Rochd, Casablanca Morocco Leila Azzouzi Professeur agrégée Cardiologie CHU Ibn Rochd, Casablanca Morocco Rachida Habbal Professeur agrégée Cardiologie CHU Ibn Rochd, Casablanca Morocco POSTER PRESENTATION
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