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PLoS One 2014; 9(5): e9668. …continued from page 139 Dr Sanjiv Patel, an interventional cardiologist at Memorial Care Heart & Vascular Institute at Orange Coast Medical Centre, agreed. ‘The key is multiple medications, but at low doses, because high doses can also cause side effects and problems,’ he told Healthline. However, Broukhim questions whether this particular article will change how physicians treat high blood pressure for several reasons. For example, patients may have other health conditions, such as diabetes, heart disease or rheumatoid conditions, that need to be treated alongside high blood pressure. ‘There are multiple decisions that make a oncesize-fits-all approach for the treatment of hypertension very difficult,’ he said. In addition, it’s more challenging for patients to take several pills every day. ‘Nobody wants to take multiple medications,’ said Patel. One solution to this is combining several drugs in a single pill, which is known as a polypill. Patel said this can help patients take their medications regularly. Research supports this, at least with cardiovascular medications. In the study, patients who had a heart attack adhered better to their medicine regimen if they were given a polypill versus multiple pills. One challenge with polypills, though, is adjusting the medication to fit the needs of the patient. ‘If you have to change one of the medications, then you have to change the whole pill,’ said Patel. Broukhim said polypills for blood pressure-lowering medications may not be possible with the current state of the pharmaceutical industry. Medications that would work together may be manufactured by different companies, which would require them to agree to combining their drug with others in a single pill. Source: MedicalBrief 2023
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