Cardiovascular Journal of Africa: Vol 34 No 4 (SEPTEMBER/OCTOBER 2023)

CARDIOVASCULAR JOURNAL OF AFRICA • Volume 34, No 4, September/October 2023 236 AFRICA systematic review of 37,030 patients. Cardiol Rev 2019; 27(5): 249–255. 10. Rashid HN, Layland J. Modification of the left atrial appendage and its role in stroke risk reduction with non-valvular atrial fibrillation. Int J Cardiol Heart Vasc 2020; 32: 100688. 11. Wu J, Zhang Y, Liao X, et al. Anticoagulation Therapy for Non-valvular Atrial Fibrillation: A Mini-Review. Front Med (Lausanne) 2020; 7: 350. 12. Yaghi S, Chang AD, Akiki R, et al. The left atrial appendage morphology is associated with embolic stroke subtypes using a simple classification system: A proof of concept study. J Cardiovasc Comput Tomogr 2020; 14(1): 27–33. 13. Karim N, Ho SY, Nicol E, et al. The left atrial appendage in humans: Structure, physiology, and pathogenesis. Europace 2020; 22(1): 5–18. 14. Wei Y, Cui M, Liu SW. Increased hemoglobin A1c level associates with low left atrial appendage flow velocity in patients of atrial fibrillation. Nutr Metab Cardiovasc Dis 2021; 31(11): 3176–3183. 15. Mostafa S, El-Rabbat K, Salah S, et al. Association of left atrial deformation indices with left atrial appendage thrombus in patients with nonvalvular atrial fibrillation. Indian Heart J 2020; 72(4): 265–271. 16. Sulzgruber P, Wassmann S, Semb AG, et al. Oral anticoagulation in patients with non-valvular atrial fibrillation and a CHA2DS2-VASc score of 1: A current opinion of the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy and European Society of Cardiology Council on Stroke. Eur Heart J Cardiovasc Pharmacother 2019; 5(3): 171–180. 17. Zhang Y, Yuan YQ. Value of left atrial diameter with CHA2DS2-VASc score in predicting left atrial/left atrial appendage thrombosis in nonvalvular atrial fibrillation. Arq Bras Cardiol 2021; 116(2): 325–331. 18. Proietti M, Rivera-Caravaca JM, Esteve-Pastor MA, et al. Stroke and thromboembolism in warfarin-treated patients with atrial fibrillation: Comparing the CHA2DS2-VASc and GARFIELD-AF risk scores. Thromb Haemost 2021; 121(8): 1107–1114. 19. Khan M, Muthukumar L, Galazka P, et al. Nonvisualization of the left atrial appendage and role of multimodality imaging. CASE (Phila), 2020; 5(1): 4–6. 20. He J, Fu Z, Yang L, et al. The predictive value of a concise classification of left atrial appendage morphology to thrombosis in non-valvular atrial fibrillation patients. Clin Cardiol 2020; 43(7): 789–795. 21. Straube F, Pongratz J, Hartl S, et al. Cardiac computed tomography angiography-derived analysis of left atrial appendage morphology and left atrial dimensions for the prediction of atrial fibrillation recurrence after pulmonary vein isolation. Clin Cardiol 2021; 44(11): 1636–1645. 22. Adukauskaite A, Barbieri F, Senoner T, et al. Left atrial appendage morphology and left atrial wall thickness are associated with cardioembolic stroke. J Clin Med 2020; 9(12): 3944–3952. Snoring and apnoea linked to higher stroke risk: US study Experts have found that people with the common sleep disorder apnoea, which has hundreds of millions of sufferers worldwide, are five times likelier to develop atrial fibrillation. They said that a number of people with apnoea, symptoms of which include stopping and starting breathing, making snorting noises, waking up a lot and loud snoring, can go undiagnosed, reports The Guardian. The condition is already known to heighten the risk of serious health problems such as high blood pressure, type 2 diabetes and depression, but now the US researchers have uncovered even more evidence about its impact on the heart, saying it significantly raises the risk of atrial fibrillation and stroke. The findings were discussed by doctors at the annual meeting of the European Society of Cardiology, the world’s largest heart conference, in Amsterdam, reports The Guardian. Studies involving experts from Stanford University looked at about 1.7 million people aged 20 to 50 years over a decade. Those with sleep apnoea were five times more likely to develop atrial fibrillation and 60% more likely to experience a stroke later in life, they found. Sanjiv Narayan, a professor of cardiovascular medicine at Stanford and the study’s author, said: ‘We found a 60% increased risk of having a stroke if you have sleep apnoea. The condition is really common but we tend to ignore it because we think it’s trivial or just a nuisance. Until now, no one’s really shown the magnitude of the size of the risk. That’s what really surprised us – and also this is in the relatively young.’ Sleep apnoea happens if your airways become too narrow while you sleep. This stops you breathing properly. Its causes are not always clear, but it has been linked to factors such as obesity, having a large neck, smoking and drinking alcohol, and sleeping on your back. Atrial fibrillation causes an irregular and often abnormally fast heart rate. Narayan said: ‘When you are unable to breathe, it raises the pressure in the lungs until you ultimately wake up gasping for breath. That puts a pressure load on the heart, which causes stretch in the heart chambers, and could cause the atrial fibrillation. Another theory could be that the oxygen levels in the blood fall for tens of seconds, which could put stress on the heart.’ Source: MedicalBrief 2023

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