CARDIOVASCULAR JOURNAL OF AFRICA • Volume 34, No 5, November/December 2023 AFRICA 275 killer, threatening human health due to its high complication, disability and mortality rates. Its major pathophysiological mechanism is that due to the rupture of unstable plaques in coronary atherosclerosis and vasospasm induced by a variety of factors, platelet adhesion and aggregation, as well as secondary thrombosis occur.7 There is a close association between the formation of atherosclerotic plaques and ACS, and related cardiovascular events are caused by the rupture of unstable plaques. Despite the certain significance of traditional risk factors (such as blood lipid levels) and cardiac imaging for the diagnosis and prevention of ACS, rupture of unstable plaque remains the direct cause of acute coronary events. However, the above methods fail to clearly reflect the rupture tendency of unstable plaques and identify the exact timing of rupture. Therefore, it has Table 3. Correlations between Lp-PLA2 concentration and variables Independent variable r p-value Height (m) 0.06 0.47 Body weight (kg) 0.13 0.10 BMI (kg/m2) 0.21 0.01 hs-CRP (mg/l) 0.29 0 TG (mmol/l) 0.05 0.54 LDL-C (mmol/l) 0.25 0 HDL-C (mmol/l) 0.16 0.84 Gensini score 0.13 0.11 TNI (ng/ml) 0.18 0.02 BMI: body mass index; HDL-C: high-density lipoprotein cholesterol; hs-CRP: high-sensitivity C-reactive protein; LDL-C: low-density lipoprotein cholesterol; Lp-PLA2: lipoprotein-associated phospholipase A2; TG: triglyceride; TNI: troponin I. NC hs-CRP (mg/l) 0.00 20.00 40.00 60.00 80.00 100.00 120.00 Lp-PLA2 (ng/ml) 600.00 400.00 200.00 0.00 UA ACS Fig. 2. Correlation between Lp-PLA2 and hs-CRP levels.ACS: acute coronary syndrome; hs-CRP: high-sensitivity C-reactive protein; Lp-PLA2: lipoprotein-associated phospholipase A2; NC: normal control; UA: unstable angina. NC LDL-C (mmol/l) 1.00 2.00 3.00 4.00 5.00 6.00 Lp-PLA2 (ng/ml) 600.00 400.00 200.00 0.00 UA ACS Fig. 3. Correlation between Lp-PLA2 and LDL-C levels. ACS: acute coronary syndrome; LDL: low-density lipoprotein; Lp-PLA2: lipoprotein-associated phospholipase A2; NC: normal control; UA: unstable angina,. NC BMI 15.00 20.00 25.00 30.00 35.00 Lp-PLA2 (ng/ml) 600.00 400.00 200.00 0.00 UA ACS Fig. 4. Correlation between Lp-PLA2 level and BMI. ACS: acute coronary syndrome; BMI: body mass index; Lp-PLA2: lipoprotein-associated phospholipase A2; NC: normal control; UA: unstable angina. NC TNI (μg/l) 0.00 20.00 40.00 60.00 80.00 100.00 Lp-PLA2 (ng/ml) 600.00 400.00 200.00 0.00 UA ACS Fig. 5. Correlation between Lp-PLA2 level and TNI. ACS: acute coronary syndrome; Lp-PLA2: lipoprotein-associated phospholipase A2; NC: normal control; TNI: troponin I; UA: unstable angina.
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