Cardiovascular Journal of Africa • SAHS Biennial Congress 2024 21 AFRICA Submission ID: 1615 Introduction Peripartum cardiomyopathy (PPCM) is associated with increased morbidity and mortality among women of childbearing age and costly intensive care unit (ICU) admission. The aim of this study was to investigate the clinical outcomes of peripartum cardiomyopathy at a tertiary level hospital in South Africa. Methods This was a cross-sectional retrospective study undertaken from 1 January 2019 to 30 June 2022 at Dr George Mukhari Academic Hospital (DGMAH). Demographics, clinical characteristics, and laboratory and imaging findings were captured from medical records. Patient records were evaluated at time of diagnosis (baseline), up to the occurrence of an outcome and/or at six months. The threshold for significance was set at p <0.05. Results A total of 130 medical records of patients with a diagnosis of peripartum cardiomyopathy were drawn, and a total of 116 of these were found to be eligible for the study. The age of the patients ranged from 18–46 years. About 55 per cent 64 (55.17%) of patients completely recovered while 27 (23.28%) remained clinically stable, 22 (18.97%) were clinically unstable, and three (2.59%) belonged to the mortality group. Factors that were strongly associated with worse clinical outcomes were: multiparity [OR 1.99 (95% CI 0.54–4.22) p = 0.002]; higher New York Heart Association (NYHA) functional class IV [OR 1.66 (95% CI 0.71–3.84) p = 0.001]; left ventricular ejection fraction (LVEF) <25% [OR 1.03(0.91–1.81) p = 0.002], and baseline serum hyponatremia <135 mmol/L [OR 1.86 (95% CI 0.68–5.09) p <0,0001]. Baseline serum severe hyponatremia <120 mmol/L was the independent factor associated with longer hospital stay (≥30 days) [OR 1.86 (95% CI 0.68–5.09) [0.022] and 8 independently predicted mortality. A thromboembolic event was the major complication, at 18 (15.52%), with left ventricular thrombus being the most common site at 8 (44, 44%). Conclusion The study confirms previous findings from other local and international literature that majority of our patients completely recover within a period of six months. Baseline serum hyponatremia can be used as predictive factor for poor clinical outcome and longer length of stay in patients with PPCM; however, large studies to further investigate the long-term outcome of serum hyponatremia are justified Name: Presenting Author Information Article Category Abstract Title Dr Ngobese n.msiyane@gmail.com English Abstract Students - Currently enrolled postgraduate students The clinical outcome of Peripartum cardiomyopathy at a tertiary level Hospital in South Africa. Author Affiliation: Email: Dr Ngobese Science Theme Clinical Author Name & Surname Title Expertise Affiliation Email Country Nomandla Madala Prof. N n.msiyane@gmail.com POSTER PRESENTATION
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