AFRICA Cardiovascular Journal of Africa • SAHS Biennial Congress 2024 22 Submission ID: 1618 Introduction Some recent data suggest targeting aortic changes associated with hypertension has benefits beyond using the conventional blood pressure taken in the arm, in monitoring the treatment of hypertension, its complications or risk stratification of cardiovascular events. However, which of the aortic parameters better expresses the changes associated with hypertension remains controversial. The present study aimed to evaluate central aortic pressure parameters in hypertensive individuals (HTN), patients with hypertensive heart failure with a preserved ejection fraction (HFpEF) and compare these groups with a community sample of normal participants. Methods Standard criteria were used to recruit participants in the present study. Accordingly, 118 normal individuals from the general population (36.9 ±12.0 years), 55 hypertensive individuals (52.4 ±12.5 years) and 75 HFpEF patients (52.5 ±13.6 years) from the medical outpatient department and medical ward of the Sokoto Specialist Hospital, were evaluated for aortic pressure parameters. Applanation tonometry with PulsPen was utilized, based on the principles of generalized transfer function, (GTF) and it was interfaced with a computer. The results were compared among the groups using analysis of variance. In this regard, the central aortic pressure indices evaluated in the present study include forward pressure wave (Pf), backward wave (Pb), augmentation index (AIx), pulse pressure amplification (PPA), pulse wave velocity (PWV) and global reflection co-efficient (GRC). Results While PWV was significantly high (P <.0001) among the hypertensive and HFpEF groups, compared with the normal group (10.4 ±3.1m/s, 12.0 ±3.9m/s, and 7.8 ±2.5m/s), there were no significant differences in the AIx among the groups (19.2 ±6.7, 17.0 ±6.7 and 17.1 ±7.2, for HTN, HFpEF and normal groups, respectively, (P =.1410). The Pf, Pb and GRC, all showed significant changes (p <.0001) in the HTN and HFpEF groups, compared to the normal group. However, PPA was not different among the groups evaluated, (26.7 ±11.2%, 25.9 ±7.9% and 28.3 ±11.7% for HTN, HFpEF and normal groups, respectively, (P =.4170). Conclusion Although AIx, a derivative of wave reflection, is recognised by earlier studies as a correlate of cardiovascular mortality and a therapeutic target in hypertension and associated complications, in the present study, PWV, Pf, Pb and GRC all showed significant changes in the HTN and HFpEF groups compared to the normal group, beyond the AIx. Name: Presenting Author Information Article Category Abstract Title Physiology Department, College of Health Sciences, Usmanu Danfodiyo University, Sokoto adamu.bamaiyi@udusok.edu.ng English Abstract Researchers/Clinicians - Early, mid & senior career Pressure Augmentation Index Does Not Adequately Express the Aortic Changes Associated with Hypertension or Hypertensive Heart Failure with A Preserved Ejection Fraction Author Affiliation: Email: Dr Adamu Jibril Bamaiyi Science Theme Clinical Submission ID: 1618 continued on next page POSTER PRESENTATION
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