AFRICA Cardiovascular Journal of Africa • SAHS Biennial Congress 2024 26 Submission ID: 1632 Introduction Hypertension (HTN) and depression increases the burden of cardiovascular disease, and adverse blood pressure (BP) profiles worsen cardiovascular outcomes. However, the co-occurrence is poorly understood due to discrepancies in literature. Each BP profile has different underlying physiological mechanisms and specific depressive symptoms present in distinct brain areas. The aim of this study was to investigate associations of BP, depressive symptom severity and individual depressive symptoms across different BP profiles. Methods This cross-sectional study consisted of individuals with masked HTN (N=56), white-coat HTN (N=52) and normotensives (N=503). To classify various BP profiles, office BP and 24-hour ambulatory BP monitoring were used. Depressive symptoms were assessed using the 9-item Patient Health Questionnaire. Results Inmasked hypertensives, 24-hour systolic BP (SBP) (β=-0.25; P=0.046) and 24-hour diastolic BP (DBP) (β=-0.36; P=0.004) associated inversely with anhedonia while office SBP (β=0.35; P=0.006) associated with poor appetite/overeating in white-coat hypertensives. In normotensives, 24-hour (β=0.07; P=0.050) and diurnal (β=0.08; P=0.041) SBP associated with poor appetite/overeating, respectively. Additionally, office SBP (β=0.13; P=0.040), 24-hour SBP (β=0.08; P=0.025), 24-hour DBP (β=0.13; P=0.003) and diurnal DBP (β=0.09; P=0.032) associated with psychomotor impairment/agitation in normotensives. Conclusion Our results indicate that screening distinct depressive symptoms instead of focusing only on depressive symptom severity could provide a better understanding of the pathophysiological mechanisms underlying HTN and depression comorbidity, provided that there are different underlying physiological mechanisms for each BP profile. Name: Presenting Author Information Article Category Abstract Title PhD student at the North-West University padisomatsole4@gmail.com English Abstract Students - Currently enrolled postgraduate students Associations of blood pressure and depressive symptoms across different blood pressure profiles: The African-PREDICT study Author Affiliation: Email: Padiso Matsole Science Theme Clinical Authors Name & Surname Title Expertise Affiliation Email Country Padiso Matsole Miss Physiology NWU postgraduate student padisomatsole4@gmail.com South Africa Esmé Jansen van Vuren Doctor Physiology NWU senior lecturer Esme.JansenvanVuren@nwu.ac.za South Africa Gontse Mokwatsi Doctor Physiology NWU senior lecturer Gontse.Mokwatsi@nwu.ac.za South Africa POSTER PRESENTATION
RkJQdWJsaXNoZXIy NDIzNzc=